{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T23:35:25Z","timestamp":1776987325173,"version":"3.51.4"},"reference-count":16,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rofo"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study investigates the relationship between sarcopenia index (SMI), quantitative muscle and adipose tissue parameters obtained from abdominal CT, and treatment response to biological agents in patients with ankylosing spondylitis (AS).<\/jats:p>\n                  <jats:p>In this retrospective study, 62 patients (May 2015\u2013May 2024) with an initial diagnosis of AS and available abdominal CT scans at the L2 vertebral level were included. Quantitative parameters including visceral adipose tissue (VAT, cm\u00b2), subcutaneous adipose tissue (SAT, cm\u00b2), total abdominal muscle area (TAMA), psoas muscle area (PsoA), sarcopenia index (SMI), and tissue attenuation values (HU) were measured. Changes in scores after biological therapy based on the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) were used to assess treatment response. Comparative and correlation analyses were performed between body composition metrics and clinical parameters.<\/jats:p>\n                  <jats:p>Patients who achieved full recovery exhibited significantly higher TAMA, PsoA, and SMI values compared to those with partial recovery (p &lt; 0.05). These findings suggest that preserved muscle mass and quality are associated with a better response to biological therapy in AS.<\/jats:p>\n                  <jats:p>Opportunistic CT-based body composition analysis provides valuable prognostic information in AS. SMI, TAMA, and psoas muscle volume may serve as potential imaging biomarkers for predicting biological treatment response, supporting personalized management strategies.<\/jats:p>\n                  <jats:p>Quantitative assessment of abdominal muscle metrics on routine CT can offer a non-invasive and accessible tool for predicting biological treatment outcomes in ankylosing spondylitis.<\/jats:p>","DOI":"10.1055\/a-2838-0022","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T22:52:37Z","timestamp":1776984757000},"source":"Crossref","is-referenced-by-count":0,"title":["Qualitative and Quantitative Evaluation of Abdominal Fat and Muscle Tissue Volume in Patients with Ankylosing Spondylitis and Investigation of Their Possible Effects on Biological Agent Treatment Response"],"prefix":"10.1055","author":[{"given":"Nazmi","family":"Kastan","sequence":"additional","affiliation":[{"name":"Ministry of Health Antalya Training and Research Hospital, T\u00fcrkiye","place":["Antalya"],"department":["Radiology"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1947-8341","authenticated-orcid":false,"given":"\u0130clal","family":"Erdem Toslak","sequence":"additional","affiliation":[{"name":"Ministry of Health Antalya Training and Research Hospital, T\u00fcrkiye","place":["Antalya"],"department":["Radiology"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alpaslan","family":"Yavuz","sequence":"additional","affiliation":[{"name":"Ministry of Health Antalya Training and Research Hospital, T\u00fcrkiye","place":["Antalya"],"department":["Radiology"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sibel","family":"Bakirci","sequence":"additional","affiliation":[{"name":"Ministry of Health Antalya Training and Research Hospital, Muratpasa, T\u00fcrkiye","place":["Antalya"],"department":["Rheumatology"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.5606\/ArchRheumatol.2016.5915","article-title":"Application of Diffusion-Weighted Imaging in the Detection of Active Sacroiliitis and the Comparison of Apparent Diffusion Coefficient and Relative Apparent Diffusion Coefficient Values","volume":"31","author":"\u0130E Toslak","year":"2016","journal-title":"Arch Rheumatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3390\/jcm14113677","article-title":"The Genetic Background of Ankylosing Spondylitis Reveals a Distinct Overlap with Autoimmune Diseases: A Systematic Review","volume":"14","author":"T Zormpa","year":"2025","journal-title":"J Clin 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