{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:58:41Z","timestamp":1785218321618,"version":"3.55.0"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Homeopathy"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Nasal inferior turbinate hypertrophy (NITH) represents a prevalent cause of persistent nasal obstruction, second only to structural anomalies in sinonasal disorders, affecting up to 77% of patients. While medical therapies such as intranasal corticosteroids serve as first-line treatments, persistent cases may necessitate surgery with risks of complications and recurrence. Despite widespread clinical use, evidence evaluating individualized homeopathic medicines (IHMs) for NITH remains limited.<\/jats:p>\n                  <jats:p>This prospective, single-group, quasi-experimental study enrolled 50 participants aged 12 to 65 years with NITH (ICD-11: CA0E) at a homeopathic outpatient department in India. IHMs were prescribed in centesimal potencies according to classical principles, with adjunctive advice on vapor inhalation and dust avoidance, including minimizing exposure to house dust, avoiding carpets and heavy curtains, regular wet cleaning, and washing bedding in hot water. The primary outcome was the Nasal Obstruction Symptom Evaluation (NOSE; 0\u2013100) score; secondary outcomes were the Sino-Nasal Outcome Test-22 (SNOT-22; 0\u2013110) and Measure Yourself Medical Outcome Profile, Version 2 (MYMOP-2; 0\u20136). Assessments were conducted at baseline and monthly for 3 months, analyzed using repeated-measures analysis and mixed-effects models under intention-to-treat principles.<\/jats:p>\n                  <jats:p>Fifty participants were enrolled; 42 completed follow-up. Statistically significant changes over time were observed across all outcomes (all p\u2009&lt;\u20090.001). Mean NOSE scores changed from 80.8\u2009\u00b1\u200924.9 (standard deviation [SD]) at baseline to 11.7\u2009\u00b1\u200912.0 at 3 months. SNOT-22 scores changed from 56.6\u2009\u00b1\u200922.4 to 6.4\u2009\u00b1\u20096.2, and median MYMOP-2 scores from 5.0 (interquartile range [IQR] 2.7\u20135.5) to 1.0 (1.0\u20132.7).<\/jats:p>\n                  <jats:p>Individualized homeopathic management under a structured protocol was associated with reductions in patient-reported sinonasal symptoms over 3 months. The single-group design and absence of objective measures preclude causal inference. Randomized controlled trials are required to determine specific efficacy.<\/jats:p>\n                  <jats:p>CTRI\/2024\/03\/064366.<\/jats:p>","DOI":"10.1055\/a-2840-2293","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T22:47:46Z","timestamp":1785192466000},"source":"Crossref","is-referenced-by-count":0,"title":["Individualized Homeopathic Medicines in the Treatment of Nasal Inferior Turbinate Hypertrophy in Adolescents and Adults: An Open-Label, Single-Group, Quasi-Experimental Clinical Study"],"prefix":"10.1055","author":[{"given":"Ruma","family":"Khatun","sequence":"additional","affiliation":[{"name":"Department of Materia Medica, D. N. De Homoeopathic Medical College and Hospital, Government of West Bengal, Tangra, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpita","family":"Basu","sequence":"additional","affiliation":[{"name":"Department of Materia Medica, D. N. De Homoeopathic Medical College and Hospital, Government of West Bengal, Tangra, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Sakhawat","family":"Hossain","sequence":"additional","affiliation":[{"name":"Department of Materia Medica, D. N. De Homoeopathic Medical College and Hospital, Government of West Bengal, Tangra, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saima","family":"Shamim","sequence":"additional","affiliation":[{"name":"Department of Materia Medica, D. N. De Homoeopathic Medical College and Hospital, Government of West Bengal, Tangra, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumya","family":"Bhattacharyya","sequence":"additional","affiliation":[{"name":"Department of Materia Medica, D. N. De Homoeopathic Medical College and Hospital, Government of West Bengal, Tangra, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amitava","family":"Paul","sequence":"additional","affiliation":[{"name":"Hospital Section, D. N. De Homoeopathic Medical College and Hospital, Government of West Bengal, Tangra, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Washim Reza","family":"Molla","sequence":"additional","affiliation":[{"name":"Department of Materia Medica, D. N. De Homoeopathic Medical College and Hospital, Government of West Bengal, Tangra, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sk Saklin","family":"Mustak","sequence":"additional","affiliation":[{"name":"Department of Practice of Medicine, D. N. De Homoeopathic Medical College and Hospital, Government of West Bengal, affiliated to the West Bengal University of Health Sciences, Tangra, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srijana","family":"Panda","sequence":"additional","affiliation":[{"name":"Department of Repertory, D. N. De Homeopathic Medical College and Hospital, Government of West Bengal, affiliated to The West Bengal University of Health Sciences, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munmun","family":"Koley","sequence":"additional","affiliation":[{"name":"Department of Health and Family Welfare, East Bishnupur State Homoeopathic Dispensary, South 24 Parganas, under the Government of West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhranil","family":"Saha","sequence":"additional","affiliation":[{"name":"Department of Repertory, D. N. De Homeopathic Medical College and Hospital, Government of West Bengal, affiliated to The West Bengal University of Health Sciences, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"628","DOI":"10.3399\/bjgp19X707057","article-title":"Nasal obstruction: a common presentation in primary care","volume":"69","author":"S Mohamed","year":"2019","journal-title":"Br J Gen Pract"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1177\/014556131809700615","article-title":"Nasal airway obstruction: Prevalence and anatomic contributors","volume":"97","author":"D W Clark","year":"2018","journal-title":"Ear Nose Throat J"},{"key":"ref4","first-page":"e34280","article-title":"Surgical management of inferior turbinate hypertrophy in the era of widespread communicable disease","volume":"15","author":"D H Smith","year":"2023","journal-title":"Cureus"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"386e","DOI":"10.1097\/PRS.0000000000002934","article-title":"Does the effect of inferior turbinate outfracture persist?","volume":"139","author":"D C Lee","year":"2017","journal-title":"Plast Reconstr Surg"},{"key":"ref6","first-page":"13","article-title":"Individualized homeopathic medicines in chronic rhinosinusitis: randomized, double-blind, placebo-controlled trial","volume":"110","author":"P Misra","year":"2021","journal-title":"Homeo-pathy"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.53945\/2320-7094.1225","article-title":"A randomised, double-blind and placebo-controlled parallel-arm trial to assess the effect of homoeopathic medicines on chronic rhinosinusitis","volume":"17","author":"P Oberai","year":"2023","journal-title":"Indian J Res Homoeopathy"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1055\/s-0043-1762591","article-title":"Individualized homeopathic medicines in the management of symptomatic adenotonsillar hypertrophy in children: a prospective observational study","volume":"113","author":"H B Ponnam","year":"2024","journal-title":"Homeopathy"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"280","DOI":"10.53945\/2320-7094.2009","article-title":"Effectiveness of individualised homoeopathy in hypertrophied adenoids in pediatric population: a single-arm prospective pilot study","volume":"19","author":"S Ussi","year":"2025","journal-title":"Indian J Res Homoeopathy"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"100495","DOI":"10.1016\/j.aimed.2025.100495","article-title":"Individualized homeopathic medicines in the treatment of chronic tonsillitis in adults: randomized, double-blind, placebo-controlled trial","volume":"4","author":"A Sarkar","year":"2025","journal-title":"Adv Integr Med"},{"key":"ref13","volume-title":"Tobacco, Alcohol, Prescription Medication, and Other Substance Use (TAPS) Tool","author":"National Institute on Drug Abuse","year":"2020"},{"key":"ref14","volume-title":"Good Manufacturing Practices for Homoeopathic Medicines","author":"Government of India, Ministry of AYUSH","year":"2018"},{"key":"ref15","volume-title":"Orientation guidelines for Community Health Officers (CHOs) under Homoeopathy stream","author":"Ministry of AYUSH, Government of India","year":"2025"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.homp.2006.11.006","article-title":"Reporting data on homeopathic treatments (RedHot): an extension of the CONSORT statement","volume":"96","author":"M E Dean","year":"2007","journal-title":"Homeopathy"},{"key":"ref17","first-page":"304","article-title":"Effects of temperature changes on nasal patency","volume":"48","author":"R Yogeetha","year":"2007","journal-title":"Singapore Med J"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.otohns.2003.09.016","article-title":"Development and validation of the Nasal Obstruction Symptom Evaluation (NOSE) scale","volume":"130","author":"M G Stewart","year":"2004","journal-title":"Otolaryngol Head Neck Surg"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1749-4486.2009.01995.x","article-title":"Psychometric validity of the 22-item Sinonasal Outcome Test","volume":"34","author":"C Hopkins","year":"2009","journal-title":"Clin Otolaryngol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1136\/bmj.312.7037.1016","article-title":"Measuring outcomes in primary care: a patient generated measure, MYMOP, compared with the SF-36 health survey","volume":"312","author":"C Paterson","year":"1996","journal-title":"BMJ"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1002\/lary.30684","article-title":"Efficacy of septoplasty in patients with nasal obstruction: a systematic review and meta-analysis","volume":"133","author":"M Alessandri-Bonetti","year":"2023","journal-title":"The Laryngoscope"},{"key":"ref22","doi-asserted-by":"crossref","DOI":"10.4135\/9781412983419","volume-title":"ANOVA: Repeated Measures","author":"E R Girden","year":"1992"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"F Faul","year":"2007","journal-title":"Behav Res Methods"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4103\/0974-7788.59946","article-title":"Sample size calculation","volume":"1","author":"P Kadam","year":"2010","journal-title":"Int J Ayurveda Res"},{"key":"ref25","volume-title":"Common Terminology Criteria for Adverse Events (CTCAE) v5.0","author":"U.S. Department of Health and Human Services","year":"2017"},{"key":"ref26","volume-title":"Homoeopathy\u2014Glossary of Terms: Standardized Terminology for Commonly Used Terms Related to Homoeopathy","author":"Bureau of Indian Standards","year":"2024"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2105\/AJPH.94.3.361","article-title":"Improving the reporting quality of nonrandomized evaluations of behavioral and public health interventions: the TREND statement","volume":"94","author":"D C Des Jarlais","year":"2004","journal-title":"Am J Public Health"}],"container-title":["Homeopathy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2840-2293.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:02:25Z","timestamp":1785214945000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2840-2293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,27]]},"references-count":24,"URL":"https:\/\/doi.org\/10.1055\/a-2840-2293","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1475-4916","1476-4245"],"issn-type":[{"value":"1475-4916","type":"print"},{"value":"1476-4245","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,27]]}}}