{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T23:04:40Z","timestamp":1784588680262,"version":"3.55.0"},"reference-count":74,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background Neurodegenerative diseases are an increasing challenge for\n                    healthcare systems in the context of demographic change. They affect the central\n                    nervous system, including the brain\u2013manifesting, for example, as dementia\u2013as\n                    well as the retina, as seen in glaucoma or age-related macular degeneration.\n                    Malnutrition\u2013defined as quantitative or qualitative under- or\n                    overnutrition\u2013affects key mechanisms that contribute to neuronal and retinal\n                    neurodegeneration.<\/jats:p>\n                  <jats:p>Objective The aim of this study is to systematically present the\n                    pathophysiological mechanisms of malnutrition-related neurodegeneration, to\n                    evaluate the current evidence on dietary patterns and cognitive health, and to\n                    derive practical clinical strategies for nutritional optimization.<\/jats:p>\n                  <jats:p>Methods Narrative literature review based on peer-reviewed publications\n                    from the fields of nutritional medicine, geriatrics, neurology, ophthalmology,\n                    and public health.<\/jats:p>\n                  <jats:p>Results Malnutrition promotes oxidative stress, mitochondrial dysfunction,\n                    chronic neuroinflammation, and vascular dysregulation, and it influences\n                    neurotransmitter synthesis. These mechanisms are relevant to both cerebral and\n                    ocular neurodegenerative processes. The Mediterranean diet and the MIND diet are\n                    associated with a significantly reduced risk of cognitive impairment; for ocular\n                    diseases, interventional studies in age-related macular degeneration in\n                    particular demonstrate protective effects of antioxidant supplementation,\n                    whereas evidence for glaucoma is currently based predominantly on observational\n                    data. Screening approaches and micronutrient diagnostics enable early\n                    identification of at-risk individuals. Building on this, individualised dietary\n                    interventions and targeted supplementation of selected nutrients could be\n                    potentially preventive and stabilising therapeutic strategies.<\/jats:p>\n                  <jats:p>Conclusion Malnutrition is a key modifiable risk factor for\n                    neurodegenerative diseases of the brain and retina. More intense integration of\n                    nutritional diagnostics and therapy into neurological, geriatric, and\n                    ophthalmological care structures appears warranted.<\/jats:p>","DOI":"10.1055\/a-2841-0517","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T23:08:07Z","timestamp":1782169687000},"page":"742-750","source":"Crossref","is-referenced-by-count":0,"title":["Malnutrition as a Risk Factor for Cerebral and Glaucomatous\n                    Neurodegeneration \u2013 Mechanisms and Therapeutic Strategies"],"prefix":"10.1055","volume":"243","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3473-7997","authenticated-orcid":false,"given":"Julia","family":"Prinz","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsmedizin der Johannes\n                    Gutenberg-Universit\u00e4t Mainz, Deutschland"},{"name":"Klinik f\u00fcr Augenheilkunde, Uniklinik RWTH Aachen,\n                    Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Prokosch","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsmedizin der Johannes\n                    Gutenberg-Universit\u00e4t Mainz, Deutschland"},{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum K\u00f6ln,\n                    Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"21","DOI":"10.2147\/EB.S293765","article-title":"Glaucoma as Neurodegeneration in the Brain","volume":"13","author":"J W Chan","year":"2021","journal-title":"Eye Brain"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1055\/a-2239-0290","article-title":"The Impact of Aging on the Function of Retinal Ganglion Cells","volume":"241","author":"J 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