{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T23:10:24Z","timestamp":1778281824582,"version":"3.51.4"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Primary hyperparathyroidism is a prevalent endocrine disorder marked by excessive\n                    parathyroid hormone secretion. Beyond its classical biochemical features,\n                    accumulating evidence suggests that primary hyperparathyroidism may adversely\n                    affect cardiovascular homeostasis. In this context, we aimed to evaluate whether\n                    patients with primary hyperparathyroidism exhibit impaired vascular function and\n                    heightened systemic inflammation compared with matched healthy controls. This\n                    cross-sectional study initially recruited 39 patients with primary\n                    hyperparathyroidism. After predefined exclusion criteria were applied, 30\n                    patients with primary hyperparathyroidism were included and compared with 45\n                    age-, sex-, and body mass index\u2013matched healthy controls. Endothelium dependent\n                    and independent vasodilation were assessed using venous occlusion\n                    plethysmography. High-sensitivity C-reactive protein levels were measured.\n                    Endothelium-independent vasodilation was reduced in primary hyperparathyroidism\n                    compared to controls (\u221215.5%; p=0.01), indicating vascular smooth muscle\n                    dysfunction. High-sensitivity C-reactive protein levels were significantly\n                    higher in primary hyperparathyroidism (905.7%; p&lt;0.001). The mean\n                    arterial pressure was elevated (~12.2%; p&lt;0.001), with a higher\n                    prevalence of hypertension (60% vs. 35.6%; p=0.03). These findings\n                    suggest that primary hyperparathyroidism is associated with impaired vascular\n                    function and systemic inflammation, even in patients without overt\n                    cardiovascular disease. This highlights a possible subclinical cardiovascular\n                    risk in primary hyperparathyroidism and supports the need for further\n                    longitudinal studies to confirm these associations and their clinical\n                    relevance.<\/jats:p>","DOI":"10.1055\/a-2841-7309","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T22:56:02Z","timestamp":1775775362000},"page":"193-198","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Endothelial Responses in Individuals With Primary\n                    Hyperparathyroidism"],"prefix":"10.1055","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1293-9547","authenticated-orcid":false,"given":"Thiago Siqueira","family":"Chagas","sequence":"additional","affiliation":[{"name":"Endocrinology, Hospital Universitario Pedro Ernesto,\n                    Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karynne Grutter","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, State University\n                    of Rio de Janeiro Roberto Alcantara Gomes Institute of Biology, Rio de Janeiro,\n                    Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Antonio Gon\u00e7alves Bastos","family":"Torres","sequence":"additional","affiliation":[{"name":"Scientific Initiation Program, Faculty of Medical\n                    Sciences, State University of Rio de Janeiro Biomedical Centre, Rio de Janeiro,\n                    Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e1rbara","family":"Gehrke","sequence":"additional","affiliation":[{"name":"Endocrinology, Department of Internal Medicine, Faculty\n                    of Medical Sciences, State University of Rio de Janeiro Biomedical Centre, Rio\n                    de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lia Roque","family":"Assump\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Faculty of Medical\n                    Sciences, State University of Rio de Janeiro Biomedical Centre, Rio de Janeiro,\n                    Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cristina Araujo","family":"Maya","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Faculty of Medical\n                    Sciences, State University of Rio de Janeiro Biomedical Centre, Rio de Janeiro,\n                    Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliete","family":"Bouskela","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisas Cl\u00ednicas e Experimentais em\n                    Biologia Vascular (Biovasc), Universidade do Estado do Rio de Janeiro, Rio de\n                    Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Guilherme","family":"Kraemer-Aguiar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Rio de Janeiro State\n                    University Faculty of Medical Sciences, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Caroline Alves","family":"Coelho","sequence":"additional","affiliation":[{"name":"Endocrinology, Department of Internal Medicine, Faculty\n                    of Medical Sciences, State University of Rio de Janeiro Biomedical Centre, Rio\n                    de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"637","DOI":"10.4252\/wjsc.v6.i5.637","article-title":"Impact of parathyroid hormone on bone marrow-derived stem cell mobilization and\n                    migration","volume":"6","author":"B C Huber","year":"2014","journal-title":"World J Stem Cells"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"h2723","DOI":"10.1136\/bmj.h2723","article-title":"The diagnosis and management of hypercalcaemia","volume":"350","author":"S Minisola","year":"2015","journal-title":"Bmj"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1002\/jbmr.4682","article-title":"Management of primary hyperparathyroidism","volume":"37","author":"J P Bilezikian","year":"2022","journal-title":"J Bone Miner Res"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"823","DOI":"10.2310\/JIM.0b013e318214edf8","article-title":"Parathyroid hormone and mobilization of circulating bone marrow-derived cells in\n                    uremic patients","volume":"59","author":"G Coppolino","year":"2011","journal-title":"J Invest Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2377","DOI":"10.1210\/jc.2011-0569","article-title":"Nephrolithiasis and renal calcifications in primary hyperparathyroidism","volume":"96","author":"L Rejnmark","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/s0008-6363(97)00194-6","article-title":"Cardiovascular actions of parathyroid hormone and parathyroid hormone-related\n                    peptide","volume":"37","author":"K D Schl\u00fcter","year":"1998","journal-title":"Cardiovasc Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1093\/clinchem\/46.10.1626","article-title":"Plasma nitric oxide concentrations and nitric oxide synthase gene polymorphisms\n                    in coronary artery disease","volume":"46","author":"Y Yoon","year":"2000","journal-title":"Clin Chem"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9582319","article-title":"Parathyroid hormone causes endothelial dysfunction by inducing mitochondrial ros\n                    and specific oxidative signal transduction modifications","volume":"2018","author":"J Gambardella","year":"2018","journal-title":"Oxid Med Cell Longev"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"S142","DOI":"10.1097\/00005344-199800001-00042","article-title":"Expression of parathyroid hormone\/parathyroid hormone-related protein receptor\n                    in vascular endothelial cells","volume":"31","author":"B Jiang","year":"1998","journal-title":"J Cardiovasc Pharmacol"},{"key":"ref10","volume-title":"Blood Pressure Measurement","author":"S Rehman","year":"2025"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.ecns.2021.03.006","article-title":"Using social media and snowball sampling as an alternative recruitment strategy\n                    for research","volume":"55","author":"K Leighton","year":"2021","journal-title":"Clin Simul Nurs"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1111\/j.1365-2265.2012.04485.x","article-title":"Endothelial function in mild primary hyperparathyroidism","volume":"78","author":"A L Carrelli","year":"2013","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/s0008-6363(00)00130-9","article-title":"Impaired flow-mediated vasodilation of the brachial artery in patients with\n                    primary hyperparathyroidism improves after parathyroidectomy","volume":"47","author":"M Kosch","year":"2000","journal-title":"Cardiovasc Res"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"139","DOI":"10.3109\/00365513.2010.543694","article-title":"Increased markers of inflammation and endothelial dysfunction in patients with\n                    mild primary hyperparathyroidism","volume":"71","author":"E G Almqvist","year":"2011","journal-title":"Scand J Clin Lab Invest"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1111\/cen.13418","article-title":"Is primary hyperparathyroidism a cause of endothelial dysfunction?","volume":"87","author":"S Colak","year":"2017","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"e2342","DOI":"10.1210\/clinem\/dgae053","article-title":"Carotid intima-media thickness in surgically or conservatively managed patients\n                    with primary hyperparathyroidism","volume":"109","author":"V Carnevale","year":"2024","journal-title":"J Clin Endocrinol Metab"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1111\/cen.15210","article-title":"Curative parathyroidectomy in primary hyperparathyroidism improves both systolic\n                    and diastolic cardiac dysfunction: A six-month follow-up study at a tertiary\n                    care hospital","volume":"102","author":"A Qadir","year":"2025","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1093\/ejendo\/lvae109","article-title":"No effect of surgery on kidney and cardiovascular risk factors in mild primary\n                    hyperparathyroidism: Secondary analyses from a 10-year randomized controlled\n                    trial","volume":"191","author":"A Heck","year":"2024","journal-title":"Eur J Endocrinol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"117130","DOI":"10.1016\/j.bone.2024.117130","article-title":"Association between primary hyperparathyroidism and cardiovascular outcomes: A\n                    systematic review and meta-analysis","volume":"185","author":"S K Kong","year":"2024","journal-title":"Bone"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1007\/s12020-020-02519-7","article-title":"The influence of parathyroidectomy on cardiometabolic risk factors in patients\n                    with primary hyperparathyroidism: A systematic review and meta-analysis","volume":"72","author":"M Yavari","year":"2021","journal-title":"Endocrine"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1016\/j.surg.2013.06.047","article-title":"Cardiovascular dysfunction in symptomatic primary hyperparathyroidism and its\n                    reversal after curative parathyroidectomy: Results of a prospective case control\n                    study","volume":"154","author":"G Agarwal","year":"2013","journal-title":"Surgery"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"154","DOI":"10.3109\/10641960903254471","article-title":"Long-term effects of parathyroidectomy on hypertension prevalence and circadian\n                    blood pressure profile in primary hyperparathyroidism","volume":"32","author":"C A Feldstein","year":"2010","journal-title":"Clin Exp Hypertens"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"F1215","DOI":"10.1152\/ajprenal.00406.2006","article-title":"Parathyroid hormone stimulates endothelial expression of atherosclerotic\n                    parameters through protein kinase pathways","volume":"292","author":"G Rashid","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1007\/bf03346518","article-title":"Endothelial function and endothelial nitric oxide synthase intron 4a\/b\n                    polymorphism in primary hyperparathyroidism","volume":"32","author":"A Ekmekci","year":"2009","journal-title":"J Endocrinol Invest"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2841-7309.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:41:04Z","timestamp":1778280064000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2841-7309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,9]]},"references-count":24,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2026,5,8]]},"published-print":{"date-parts":[[2026,5]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2841-7309","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,9]]}}}