{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:39:56Z","timestamp":1780393196488,"version":"3.54.1"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Purpose Primary hyperparathyroidism has been associated with subclinical\n                    neuromuscular dysfunction; however, the clinical correlates of muscle strength\n                    and morphology in PHPT remain undercharacterized. We hypothesized that muscle\n                    dysfunction in primary hyperparathyroidism is reversible after parathyroidectomy\n                    and that the reduction in serum calcium predicts early postoperative\n                    improvement.<\/jats:p>\n                  <jats:p>Design Prospective observational study conducted at a tertiary care\n                    center.<\/jats:p>\n                  <jats:p>Methods Fifty-three primary hyperparathyroidism patients and 53 age-, sex-,\n                    and body mass index-matched healthy controls were assessed using handgrip\n                    strength tests, 4-m walking speed, the timed-up-and-go test, and the five-time\n                    sit-to-stand test. The muscle thickness was measured via ultrasonography and\n                    body composition by bioelectrical impedance analysis. Surgical indications were\n                    based on international guidelines for classical primary hyperparathyroidism and\n                    on clinical judgment in selected normocalcemic cases. Thirty-four patients\n                    underwent parathyroidectomy and were re-evaluated 3 months postoperatively.\n                    Generalized linear mixed models were used to identify predictors of changes in\n                    muscle function.<\/jats:p>\n                  <jats:p>Results At baseline, patients with primary hyperparathyroidism demonstrated\n                    significantly reduced handgrip strength, prolonged durations in the\n                    timed-up-and-go and five-time sit-to-stand test tests, and decreased\n                    gastrocnemius muscle thickness compared to healthy controls (p&lt;0.05).\n                    Following parathyroidectomy, both gastrocnemius muscle thickness and lower limb\n                    functional performance (timed-up-and-go and five-time sit-to-stand test)\n                    improved significantly. Generalized linear mixed model analysis identified\n                    reductions in serum calcium as independent predictors of functional improvement.\n                    Vitamin D status was standardized across all participants to minimize\n                    confounding and enhance internal validity.<\/jats:p>\n                  <jats:p>Conclusions Parathyroidectomy in primary hyperparathyroidism patients leads\n                    to early improvements in muscle thickness and lower extremity function,\n                    suggesting a multimodal recovery process; whether assessment enhances surgical\n                    decision-making and patient selection needs to be explored in further\n                    studies.<\/jats:p>","DOI":"10.1055\/a-2841-8190","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:09:31Z","timestamp":1774483771000},"page":"158-168","source":"Crossref","is-referenced-by-count":1,"title":["Muscle Function Improves After Parathyroidectomy: The Role of Calcium\n                    Reduction Over Parathyroid Hormone Decline"],"prefix":"10.1055","volume":"134","author":[{"given":"Banu","family":"Ert\u00fcrk","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism, Hacettepe University\n                    Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didem","family":"Karaduman","sequence":"additional","affiliation":[{"name":"Geriatrics, Hacettepe University Faculty of Medicine,\n                    Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6mer","family":"Cennet","sequence":"additional","affiliation":[{"name":"General Surgery, Hacettepe University Faculty of\n                    Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet B\u00fclent","family":"Do\u011frul","sequence":"additional","affiliation":[{"name":"General Surgery, Hacettepe University Faculty of\n                    Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jale","family":"Karakaya","sequence":"additional","affiliation":[{"name":"Biostatistics, Hacettepe University Faculty of Medicine,\n                    Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meltem","family":"Halil","sequence":"additional","affiliation":[{"name":"Geriatrics, Hacettepe University Faculty of Medicine,\n                    Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alper","family":"G\u00fcrlek","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism, Hacettepe University\n                    Faculty of Medicine, Ankara, 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