{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:54:15Z","timestamp":1790898855822,"version":"4.1.0"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"14","funder":[{"name":"NIH\/ORWH Building Interdisciplinary Research Careers in Women's Health","award":["NIH K12HD043441"],"award-info":[{"award-number":["NIH K12HD043441"]}]},{"name":"NIH\/NHLBI","award":["K23HL168356"],"award-info":[{"award-number":["K23HL168356"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study aimed to evaluate the association of N-terminal pro B-type natriuretic peptide (NT-proBNP) concentration during the delivery hospitalization with persistence of postpartum hypertension and postpartum blood pressure (BP) trajectory among individuals with hypertensive disorders of pregnancy (HDP).<\/jats:p>\n                  <jats:p>This was a single-site cohort study including individuals with new-onset HDP who participated in a remote BP monitoring program and an obstetric biobank. Postpartum BP data were collected from the delivery hospitalization, remote monitoring program, and outpatient visits. Correlations between log(NT-proBNP) and BP values were assessed, and outcomes were compared between low-NT-proBNP (defined as less than 150 pg\/mL based on previously published reference intervals in pregnancy) and high-NT-proBNP (greater than or equal to 150 pg\/mL) groups.<\/jats:p>\n                  <jats:p>A total of 111 individuals were included, with 31 (27.9%) in the low-NT-proBNP group and 80 (72.1%) in the high-NT-proBNP group. Log(NT-proBNP) had a weakly positive correlation with maximum postpartum systolic (SBP) and diastolic BP (DBP) during the delivery hospitalization. Persistent postpartum hypertension, defined as antihypertensive medication or stage two hypertension at 6 weeks postpartum, occurred in 40.0% of the high-NT-proBNP group versus 19.4% of the low-NT-proBNP group (p\u2009=\u20090.04). The high-NT-proBNP group also had significantly different maximum postpartum DBP during the delivery hospitalization (101 vs. 94\u2009mm Hg, p\u2009=\u20090.01), maximum SBP during remote monitoring (145 vs. 139\u2009mm Hg, p\u2009=\u20090.049), and likelihood of being on antihypertensive medication at 6 weeks postpartum (31.3 vs. 12.9%, p\u2009=\u20090.048) and at any time between delivery and 6 weeks postpartum (48.8 vs. 22.6%, p\u2009=\u20090.01) compared with the low-NT-proBNP group. The high- versus low-NT-proBNP groups had significantly different SBP trajectories over the first 14 days postpartum, with the greatest difference noted in the first 3 to 4 days.<\/jats:p>\n                  <jats:p>NT-proBNP measurement among individuals with HDP at the time of delivery may be useful in assessing risk for persistent postpartum hypertension.<\/jats:p>","DOI":"10.1055\/a-2842-1208","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T22:47:54Z","timestamp":1775861274000},"page":"1920-1926","source":"Crossref","is-referenced-by-count":0,"title":["Association between NT-proBNP and Persistent Postpartum Hypertension among Individuals with Hypertensive Disorders of Pregnancy"],"prefix":"10.1055","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6619-466X","authenticated-orcid":false,"given":"Rosemary","family":"Shay","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie","family":"Bennett","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Smith","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Catov","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States"},{"name":"Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Jeyabalan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States"},{"name":"Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Gandley","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States"},{"name":"Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2535-0309","authenticated-orcid":false,"given":"Malamo","family":"Countouris","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisse","family":"Hauspurg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States"},{"name":"Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States"},{"name":"Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Alpert Medical School of Brown University, Providence, Rhode Island, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"issue":"12","key":"ref1","doi-asserted-by":"crossref","first-page":"e2030815","DOI":"10.1001\/jamanetworkopen.2020.30815","article-title":"Racial differences in postpartum blood pressure trajectories among women after a hypertensive disorder of pregnancy","volume":"3","author":"A Hauspurg","year":"2020","journal-title":"JAMA Netw Open"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.preghy.2022.11.009","article-title":"Blood pressure changes in gestational hypertension, preeclampsia, and chronic hypertension from preconception to 42-day postpartum","volume":"31","author":"A Palatnik","year":"2023","journal-title":"Pregnancy Hypertens"},{"issue":"19","key":"ref3","doi-asserted-by":"crossref","first-page":"e013092","DOI":"10.1161\/JAHA.119.013092","article-title":"for the NHLBI nuMoM2b Heart Health Study. Association of adverse pregnancy outcomes with hypertension 2 to 7 years postpartum","volume":"8","author":"D M Haas","year":"2019","journal-title":"J Am Heart Assoc"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s10741-014-9440-0","article-title":"A systematic review of BNP and NT-proBNP in the management of heart failure: overview and methods","volume":"19","author":"M Oremus","year":"2014","journal-title":"Heart Fail Rev"},{"issue":"02","key":"ref5","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s10741-021-10105-w","article-title":"Biomarkers for the diagnosis and management of heart failure","volume":"27","author":"V Castiglione","year":"2022","journal-title":"Heart Fail Rev"},{"issue":"08","key":"ref6","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3390\/jcdd9080256","article-title":"Biomarkers of HFpEF: natriuretic peptides, high-sensitivity troponins and beyond","volume":"9","author":"P Morfino","year":"2022","journal-title":"J Cardiovasc Dev Dis"},{"issue":"05","key":"ref7","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/MNH.0000000000000905","article-title":"Biomarker guided management of hypertension","volume":"32","author":"P A Kotta","year":"2023","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"07","key":"ref8","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1056\/NEJMoa031994","article-title":"Plasma natriuretic peptide levels and the risk of cardiovascular events and death","volume":"350","author":"T J Wang","year":"2004","journal-title":"N Engl J Med"},{"issue":"02","key":"ref9","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3349\/ymj.2010.51.2.151","article-title":"Interpretation and use of natriuretic peptides in non-congestive heart failure settings","volume":"51","author":"S-H Tsai","year":"2010","journal-title":"Yonsei Med 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