{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:54:14Z","timestamp":1790898854935,"version":"4.1.0"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"14","funder":[{"name":"The medical research project of Zhongshan Municipal Health Bureau","award":["2024A020042"],"award-info":[{"award-number":["2024A020042"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The objective of this study is to establish normative transcranial Doppler (TCD)-derived cerebral blood flow values in term and preterm neonates and to assess differences between groups and their associations with gestational age and anthropometric parameters.<\/jats:p>\n                  <jats:p>A retrospective cohort study was performed on 46 neurologically and hemodynamically stable neonates admitted to the Neonatal Ward of Zhongshan City People's Hospital between April and August 2025. TCD examinations of the anterior (ACA), middle (MCA), and posterior cerebral arteries (PCA) were completed within the first postnatal week in both term and preterm infants. Cerebral hemodynamic parameters\u2014peak systolic velocity, end-diastolic velocity, mean velocity, pulsatility index, and resistance index\u2014were compared between groups and correlated with gestational age, birth weight, and occipitofrontal head circumference.<\/jats:p>\n                  <jats:p>Hemodynamic findings showed that compared with term neonates, preterm neonates showed significantly lower blood flow velocities in the left MCA. In contrast, preterm infants exhibited significantly higher vascular resistance in multiple cerebral arteries, with the increase being more pronounced in the right hemisphere. Standardized linear regression analyses showed that gestational age and birth weight (BW) were positively associated with vascular velocity in both ACA and MCA. Models for left MCA flow velocities demonstrated moderate explanatory power (R\n                  2 values ranging from 0.25 to 0.34).<\/jats:p>\n                  <jats:p>Term and preterm neonates exhibited distinct hemodynamic profiles on TCD within the first 7 days of life. The most pronounced difference between the two groups was observed in the MCA. BW demonstrated the strongest association with these hemodynamic differences.<\/jats:p>","DOI":"10.1055\/a-2842-1293","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T23:51:47Z","timestamp":1774655507000},"page":"1927-1934","source":"Crossref","is-referenced-by-count":0,"title":["Transcranial Doppler Evaluation of Cerebral Hemodynamics in Term and Preterm Chinese Neonates Aged\u2009&lt;\u20097 days: A Retrospective Cohort Study"],"prefix":"10.1055","volume":"43","author":[{"given":"Shangwen","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Zhongshan City People's Hospital, Zhongshan, Guangdong, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinghua","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography, Zhongshan City People's Hospital, Zhongshan, Guangdong, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjian","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Shenzhen Second People's Hospital, the First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-Fang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Zhongshan City People's Hospital, Zhongshan, Guangdong, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"issue":"12","key":"ref1","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1111\/dmcn.15998","article-title":"Cerebral Doppler imaging in neonates: a guide for clinical application and diagnosis","volume":"66","author":"S Horsch","year":"2024","journal-title":"Dev Med Child Neurol"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"e15419","DOI":"10.1016\/j.heliyon.2023.e15419","article-title":"Transcranial doppler velocities in a large healthy population of African children","volume":"9","author":"N F O'Brien","year":"2023","journal-title":"Heliyon"},{"issue":"06","key":"ref3","first-page":"9","article-title":"Expert consensus on cranial ultrasound in neonates and infants","volume":"18","author":"Chinese Medical Education Association, Ultrasound Medicine Professional Committee, Pediatric Ultrasound Subgroup; Chinese Medical Association, Pediatric Society, Preparatory Group for Ultrasound Medicine","year":"2021","journal-title":"Chin J Med Ultrasound"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1055\/s-0040-1715128","article-title":"Practice recommendations for transcranial doppler ultrasonography in critically ill children in the pediatric intensive care unit: a multidisciplinary expert consensus statement","volume":"10","author":"N F O'Brien","year":"2021","journal-title":"J Pediatr Intensive Care"},{"issue":"05","key":"ref5","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.2214\/ajr.152.5.1059","article-title":"Absolute intracranial blood-flow velocities evaluated by duplex Doppler sonography in asymptomatic preterm and term neonates","volume":"152","author":"J G Horgan","year":"1989","journal-title":"AJR Am J Roentgenol"},{"issue":"09","key":"ref6","doi-asserted-by":"crossref","first-page":"497","DOI":"10.7863\/jum.1987.6.9.497","article-title":"Regional cerebral blood velocity in infants. 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