{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:21:45Z","timestamp":1787613705706,"version":"build-2736575974"},"reference-count":12,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pneumologie"],"abstract":"Zusammenfassung<\/jats:title>\n Genau vor 80 Jahren, im April 1946, auch in Chicago, dort, wo heute j\u00e4hrlich die Neuigkeiten der Onkologie auf dem ASCO diskutiert werden, wurde der deutsche Literaturnobelpreistr\u00e4ger und Kettenraucher Thomas Mann an der Lunge operiert. Ihm wurden am 24.\u2006April 1946 vom Thoraxchirurgen Dr. William E. Adams am University of Chicago Hospital der rechte Unter- und Mittellappen wegen eines Karzinoms entfernt, er \u00fcberlebte diese Operation rezidivfrei 9 Jahre, bis er an einem Aortenaneurysma verstarb. Das Besondere dieser Operation war die limitierte Resektion ohne vollst\u00e4ndige Entfernung des ganzen Lungenfl\u00fcgels, der bis dahin einzigen Behandlungsform des Lungenkarzinoms.<\/jats:p>\n Seitdem haben sich die Therapieoptionen des Lungenkarzinoms erheblich ver\u00e4ndert. Im Folgenden sollen kurz diese Entwicklungen in Diagnostik und Therapie dargestellt werden.<\/jats:p>","DOI":"10.1055\/a-2842-7532","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:44:09Z","timestamp":1787611449000},"source":"Crossref","is-referenced-by-count":0,"title":["80 Jahre Lungenkarzinom \u2013 die Entwicklung der Diagnostik und Therapie"],"prefix":"10.1055","author":[{"given":"Niels","family":"Reinmuth","sequence":"additional","affiliation":[{"name":"Asklepios Lungenklinik Gauting, Thorakale Onkologie, Mitglied des Deutschen Zentrums f\u00fcr Lungenforschung (DZL), Gauting, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Heigener","sequence":"additional","affiliation":[{"name":"Agaplesion Diakonieklinikum Rotenburg, Rotenburg (W\u00fcmme), Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claas","family":"Wesseler","sequence":"additional","affiliation":[{"name":"Asklepios Klinikum Harburg, Harburg, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1164\/rccm.201702-0433CI","article-title":"AJRCCM: 100-Year Anniversary. 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