{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T23:42:32Z","timestamp":1776469352768,"version":"3.51.2"},"reference-count":20,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The limited availability of gonadorelin has resulted in an increased use of\n                    subcutaneous triptorelin to diagnose central precocious puberty; however,\n                    studies validating its diagnostic value remain limited. This study aimed to\n                    evaluate the usefulness of subcutaneous triptorelin stimulation testing for\n                    central precocious puberty evaluation. We retrospectively reviewed the medical\n                    records of 662 girls aged less than 8 years who were tested for central\n                    precocious puberty at the Ajou University Hospital in 2021. Luteinizing hormone\n                    responses were analyzed to compare the timing of the maximal luteinizing hormone\n                    response and the earliest diagnostic point between the triptorelin and\n                    gonadorelin groups. Receiver operating characteristic curve analysis was\n                    performed to assess discriminatory ability. Central precocious puberty was\n                    diagnosed in 219 girls (130 in the gonadorelin group and 89 in the triptorelin\n                    group). Both stimulating agents elicited significant luteinizing hormone level\n                    rises in patients with central precocious puberty to similar peak luteinizing\n                    hormone levels (13.9\u00b112.8 vs. 12.8\u00b112.1\u2009IU\/L). Gonadorelin responses peaked at\n                    30 minutes, whereas triptorelin responses peaked later, with 31.5% of patients\n                    with central precocious puberty showing a maximal luteinizing hormone level at\n                    120 minutes. All patients with central precocious puberty were identified 60\n                    minutes after gonadorelin administration, whereas approximately 10% of patients\n                    with central precocious puberty were diagnosed at 90 and 120 minutes after\n                    triptorelin administration. Single-time-point luteinizing hormone measurements\n                    showed high concordance with serial sampling, peaking at 60 minutes for\n                    gonadorelin and at 120 minutes for triptorelin. A 120-minute triptorelin\n                    stimulation test demonstrates luteinizing hormone response patterns similar to\n                    those observed with gonadorelin testing and may serve as a practical option for\n                    central precocious puberty evaluation.<\/jats:p>","DOI":"10.1055\/a-2844-9524","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T22:56:02Z","timestamp":1775775362000},"page":"152-157","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Usefulness of Subcutaneous Triptorelin Stimulation Testing\n                    in the Evaluation of Central Precocious Puberty in Girls"],"prefix":"10.1055","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7691-6937","authenticated-orcid":false,"given":"Min Hyung","family":"Cho","sequence":"additional","affiliation":[{"name":"Pediatrics, Ajou University School of Medicine, Suwon-si, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonghan","family":"Kim","sequence":"additional","affiliation":[{"name":"Pediatrics, Ajou University School of Medicine, Suwon-si, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Seok","family":"Shim","sequence":"additional","affiliation":[{"name":"Pediatrics, Ajou University School of Medicine, Suwon-si, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9684-4042","authenticated-orcid":false,"given":"Hae Sang","family":"Lee","sequence":"additional","affiliation":[{"name":"Pediatrics, Ajou University School of Medicine, Suwon-si, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.6065\/apem.2448038.019","article-title":"Long-term outcomes of gonadotropin-releasing hormone agonist treatment in girls\n                    with central precocious puberty","volume":"30","author":"J Hwangbo","year":"2025","journal-title":"Ann Pediatr Endocrinol Metab"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1056\/NEJMcp0800459","article-title":"Clinical practice. 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Metab"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1365-2265.2010.03796.x","article-title":"Leuprolide stimulation testing for the evaluation of early female sexual\n                    maturation","volume":"73","author":"A Sathasivam","year":"2010","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"152","DOI":"10.6065\/apem.2040004.002","article-title":"Gonadotropin-releasing hormone stimulation test and diagnostic cutoff in\n                    precocious puberty: A mini review","volume":"25","author":"S N Ab Rahim","year":"2020","journal-title":"Ann Pediatr Endocrinol Metab"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1159\/000501336","article-title":"Use of gonadotropin-releasing hormone analogs in children: Update by an\n                    international consortium","volume":"91","author":"K Bangalore Krishna","year":"2019","journal-title":"Horm Res Paediatr"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1007\/s12020-024-04055-0","article-title":"Revising LH cut-off for the diagnosis of central precocious puberty via\n                    triptorelin stimulation assay","volume":"87","author":"P Cavarzere","year":"2025","journal-title":"Endocrine"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e4520","DOI":"10.1210\/clinem\/dgab448","article-title":"The use of morning urinary gonadotropins and sex hormones in the management of\n                    early puberty in Chinese girls","volume":"106","author":"S Zhan","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/s12098-024-05137-7","article-title":"Diagnostic value of single LH and LH\/FSH ratio at 60-minute after GnRHa\n                    stimulation test for central precocious puberty","volume":"92","author":"Q Wang","year":"2025","journal-title":"Indian J Pediatr"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1002\/uog.6148","article-title":"Evaluation of pelvic ultrasonography in the diagnosis and differentiation of\n                    various forms of sexual precocity in girls","volume":"32","author":"M Badouraki","year":"2008","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1080\/09513590.2020.1718642","article-title":"Inhibin B as a screening tool for early detection and treatment monitoring of\n                    central precocious puberty","volume":"36","author":"H R Jeong","year":"2020","journal-title":"Gynecol Endocrinol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1629423","DOI":"10.3389\/fped.2025.1629423","article-title":"A single blood luteinizing hormone level of\n                    triptorelin stimulation test can diagnose hypothalamic-pituitary-gonadal axis\n                    activation in girls with high body mass index","volume":"13","author":"B Zeng","year":"2025","journal-title":"Front\n                    Pediatr"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2844-9524.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T22:56:27Z","timestamp":1776466587000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2844-9524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":20,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2026,4,17]]},"published-print":{"date-parts":[[2026,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2844-9524","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]}}}