{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:06:52Z","timestamp":1783987612421,"version":"3.55.0"},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Eine 82-j\u00e4hrige Frau wurde mit \u00dcbelkeit, allgemeiner Schw\u00e4che und zunehmender Verwirrtheit mit dem Rettungsdienst in die Notaufnahme transportiert. Zwei Tage zuvor hatte sie im Rahmen eines Suizidversuchs 60 Tabletten Digitoxin (jeweils 0,07 mg) eingenommen.<\/jats:p>\n                  <jats:p>Im EKG zeigte sich ein normofrequenter Sinusrhythmus, ein AV-Block 1. Grades sowie ST-Streckensenkungen in den Ableitungen II, aVF und V2-V6. Der Digitoxin-Spiegel lag \u00fcber der Nachweisgrenze. Die Troponinwerte waren erh\u00f6ht.<\/jats:p>\n                  <jats:p>Digitoxin-Intoxikation mit Myokardsch\u00e4digung nach Suizidversuch.<\/jats:p>\n                  <jats:p>Bei potenziell lebensbedrohlichem Verlauf erfolgte die Gabe von Digitalis-Antitoxin (DigiFab). Unter intensivmedizinischer \u00dcberwachung besserte sich der klinische Zustand der Patientin rasch, die Digitoxin-Spiegel waren im Verlauf langsam r\u00fcckl\u00e4ufig. Nach 8 Tagen war eine Entlassung m\u00f6glich.<\/jats:p>\n                  <jats:p>Digitoxin-Intoxikationen k\u00f6nnen zu erheblichen Myokardsch\u00e4den f\u00fchren. Risikoeinsch\u00e4tzung, Therapie sowie auch die Beurteilung des Therapieansprechens sollten schnell und stets anhand des klinischen Bildes erfolgen.<\/jats:p>","DOI":"10.1055\/a-2846-3769","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T23:31:04Z","timestamp":1783985464000},"page":"768-772","source":"Crossref","is-referenced-by-count":0,"title":["Gef\u00e4hrliche \u00dcberdosis: Myokardschaden durch Digitoxin-Intoxikation"],"prefix":"10.1055","volume":"151","author":[{"given":"Olivia","family":"Tausendfreund","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Deutschland","place":["M\u00fcnchen"],"department":["Medizinische Klinik und Poliklinik IV, LMU Klinikum"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Michael","family":"Hoppe","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Deutschland","place":["M\u00fcnchen"],"department":["Medizinische Klinik und Poliklinik IV, LMU Klinikum"]},{"name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Deutschland","place":["M\u00fcnchen"],"department":["Klinikum Innenstadt, LMU Klinikum, Zentrale Notaufnahme"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2611-014X","authenticated-orcid":false,"given":"Markus","family":"W\u00f6rnle","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Deutschland","place":["M\u00fcnchen"],"department":["Klinikum Innenstadt, LMU Klinikum, Zentrale Notaufnahme"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1002\/ejhf.1452","article-title":"Rationale and design of the DIGIT-HF trial (DIGitoxin to Improve ouTcomes in patients with advanced 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