{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:34:14Z","timestamp":1786120454348,"version":"build-2736575974"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg A Cent Eur Neurosurg"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Giant cell tumors (GCTs) of the bone, though typically benign and found at the ends of long bones, are rare in the lumbar spine. Despite their benign nature, they can exhibit local aggressiveness and cause pathological fractures and compression. The treatment is individualized, considering anatomical localization, tumor extension, and clinical symptoms.<\/jats:p>\n                  <jats:p>We present the case of a 41-year-old female, a genuinely unique instance of a GCT of the L4 body extending into the retroperitoneum. This rarity in itself is a point of interest. The patient underwent an initial posterior en bloc resection with lumbar arthrodesis, followed by a second anterior L4 corpectomy and anterior cylinder fusion.<\/jats:p>\n                  <jats:p>The combination of radical surgery with adjuvant therapies such as radiotherapy and bisphosphonates has been described to enhance long-term outcomes and reduce recurrence. Still, surgery remains the mainstay of treatment of this entity.<\/jats:p>","DOI":"10.1055\/a-2846-5029","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:47:59Z","timestamp":1782514079000},"page":"382-386","source":"Crossref","is-referenced-by-count":0,"title":["Giant Cell Tumor of the Lumbar Spine with Large Retroperitoneal Extension and Vascular Attachment"],"prefix":"10.1055","volume":"87","author":[{"given":"Juan Felipe","family":"Abaunza-Camacho","sequence":"additional","affiliation":[{"name":"Center for Research and Training in Neurosurgery (CIEN), Hospital Universitario de la Samaritana, Bogot\u00e1, Colombia"},{"name":"Department of Neurosurgery, Hospital Universitario Mayor - Mederi, Bogot\u00e1, Colombia"},{"name":"Department of Neurosurgery, Spine Surgery Division, Universidad del Rosario School of Medicine and Health Sciences, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Michelle","family":"Forero-Santos","sequence":"additional","affiliation":[{"name":"Center for Research and Training in Neurosurgery (CIEN), Hospital Universitario de la Samaritana, Bogot\u00e1, Colombia"},{"name":"Department of Neurosurgery, Hospital Universitario Mayor - Mederi, Bogot\u00e1, Colombia"},{"name":"Department of Neurosurgery, Spine Surgery Division, Universidad del Rosario School of Medicine and Health Sciences, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban","family":"Ram\u00edrez-Ferrer","sequence":"additional","affiliation":[{"name":"Center for Research and Training in Neurosurgery (CIEN), Hospital Universitario de la Samaritana, Bogot\u00e1, Colombia"},{"name":"Department of Neurosurgery, Hospital Universitario Mayor - Mederi, Bogot\u00e1, Colombia"},{"name":"Department of Neurosurgery, Spine Surgery Division, Universidad del Rosario School of Medicine and Health Sciences, Bogot\u00e1, Colombia"},{"name":"Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s-Felipe","family":"Pineda-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Center for Research and Training in Neurosurgery (CIEN), Hospital Universitario de la Samaritana, Bogot\u00e1, Colombia"},{"name":"Department of Neurosurgery, Hospital Universitario Mayor - Mederi, Bogot\u00e1, Colombia"},{"name":"Department of Neurosurgery, Spine Surgery Division, Universidad del Rosario School of Medicine and Health Sciences, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William-Mauricio","family":"Riveros-Castillo","sequence":"additional","affiliation":[{"name":"Center for Research and Training in Neurosurgery (CIEN), Hospital Universitario de la Samaritana, Bogot\u00e1, Colombia"},{"name":"Department of Neurosurgery, Hospital Universitario Mayor - Mederi, Bogot\u00e1, Colombia"},{"name":"Department of Neurosurgery, Spine Surgery Division, Universidad del Rosario School of Medicine and Health Sciences, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier M.","family":"Saavedra","sequence":"additional","affiliation":[{"name":"Center for Research and Training in Neurosurgery (CIEN), Hospital Universitario de la Samaritana, Bogot\u00e1, Colombia"},{"name":"Department of Neurosurgery, Hospital Universitario Mayor - Mederi, Bogot\u00e1, Colombia"},{"name":"Department of Neurosurgery, Spine Surgery Division, Universidad del Rosario School of Medicine and Health Sciences, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Torres-Mancera","sequence":"additional","affiliation":[{"name":"Center for Research and Training in Neurosurgery (CIEN), Hospital Universitario de la Samaritana, Bogot\u00e1, Colombia"},{"name":"Department of Neurosurgery, Hospital Universitario Mayor - Mederi, Bogot\u00e1, Colombia"},{"name":"Department of Neurosurgery, Spine Surgery Division, Universidad del Rosario School of Medicine and Health Sciences, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.surneu.2007.07.056","article-title":"Giant cell tumor of the thoracic spine: case report and review of the literature","volume":"71","author":"D Refai","year":"2009","journal-title":"Surg Neurol"},{"issue":"13","key":"ref2","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.4103\/0366-6999.208239","article-title":"Recurrence factors in giant cell tumors of the spine","volume":"130","author":"H Q Ouyang","year":"2017","journal-title":"Chin Med J (Engl)"},{"issue":"04","key":"ref3","doi-asserted-by":"crossref","first-page":"857","DOI":"10.3390\/diagnostics12040857","article-title":"Diagnosis and treatment of lumbar giant cell tumor of the spine: Update on current management strategies","volume":"12","author":"A R Leggett","year":"2022","journal-title":"Diagnostics (Basel)"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12891-020-3129-4","article-title":"Recurrent giant cell tumour of the thoracic spine managed by total en bloc spondylectomy and denosumab therapy: A case report","volume":"21","author":"P G Duan","year":"2020","journal-title":"BMC Musculoskelet Disord"},{"key":"ref5","first-page":"79","article-title":"Giant cell tumor of bone in elderly patients: a study of ten patients","volume":"29","author":"E F McCarthy","year":"2009","journal-title":"Iowa Orthop J"},{"issue":"08","key":"ref6","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1007\/s00586-015-3777-5","article-title":"Treatment and outcome of primary aggressive giant cell tumor in the spine","volume":"24","author":"H Yin","year":"2015","journal-title":"Eur Spine J"},{"issue":"07","key":"ref7","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1007\/s11604-006-0064-8","article-title":"Aggressive clinical course of giant cell tumor arising from thoracic vertebra after a long latent period","volume":"24","author":"T Takahashi","year":"2006","journal-title":"Radiat Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12957-015-0438-4","article-title":"Giant cell tumor of axial vertebra: surgical experience of five cases and a review of the literature","volume":"13","author":"G Chen","year":"2015","journal-title":"World J Surg Oncol"},{"issue":"423","key":"ref9","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/01.blo.0000128643.38390.07","article-title":"Giant cell tumor of the pelvis and sacrum: 17 cases and analysis of the literature","author":"R E Leggon","year":"2004","journal-title":"Clin Orthop Relat Res"},{"issue":"S 03","key":"ref10","first-page":"E472-8","article-title":"En bloc resection of a giant cell tumor in the sacrum via a posterior-only approach without nerve root sacrifice: Technical case report","volume":"11 Suppl 3","author":"M Bydon","year":"2015","journal-title":"Neurosurgery"},{"key":"ref11","doi-asserted-by":"crossref","DOI":"10.1007\/174_2023_445","volume-title":"Giant cell tumor of the spine","author":"S Orguc","year":"2023"},{"issue":"10","key":"ref12","doi-asserted-by":"crossref","first-page":"E629","DOI":"10.1097\/BRS.0000000000001951","article-title":"Giant cell tumor of cervical spine presenting as acute asphyxia: Successful surgical resection after down-staging with denosumab","volume":"42","author":"R Kumar","year":"2017","journal-title":"Spine"},{"issue":"07","key":"ref13","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1007\/s00586-023-07753-x","article-title":"An improved total en bloc spondylectomy for L5 vertebral giant cell tumor through a single-stage posterior approach","volume":"32","author":"W Wan","year":"2023","journal-title":"Eur Spine J"},{"issue":"09","key":"ref14","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1007\/s00586-014-3263-5","article-title":"Giant cell tumors of the sacrum\u2013a nationwide study on midterm results in 26 patients after intralesional excision","volume":"23","author":"L van der Heijden","year":"2014","journal-title":"Eur Spine J"},{"issue":"06","key":"ref15","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1007\/s00586-009-1273-5","article-title":"Image-guided multilevel vertebral osteotomies for en bloc resection of giant cell tumor of the thoracic spine: case report and description of operative technique","volume":"19","author":"S M Smitherman","year":"2010","journal-title":"Eur Spine J"},{"issue":"07","key":"ref16","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1007\/s00586-009-1270-8","article-title":"Giant cell tumour of the sacrum: a suggested algorithm for treatment","volume":"19","author":"R Thangaraj","year":"2010","journal-title":"Eur Spine J"},{"issue":"07","key":"ref17","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1002\/dc.22998","article-title":"Giant cell tumor of bone presenting in the lumbar spine of a 35-year-old female: cytodiagnosis and other diagnostic considerations","volume":"42","author":"B L Witt","year":"2014","journal-title":"Diagn Cytopathol"},{"issue":"05","key":"ref18","doi-asserted-by":"crossref","first-page":"E1142","DOI":"10.1227\/01.NEU.0000245589.08463.8D","article-title":"Giant-cell tumors of the cervical spine: case report","volume":"59","author":"C L Hunter","year":"2006","journal-title":"Neurosurgery"},{"issue":"08","key":"ref19","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.otsr.2010.05.009","article-title":"Giant cells tumor recurrence at the third lumbar vertebra","volume":"96","author":"M Mestiri","year":"2010","journal-title":"Orthop Traumatol Surg Res"},{"key":"ref20","first-page":"69","article-title":"Giant cell tumor of the sacrum and spine: series of 23 cases and a review of the literature","volume":"30","author":"C Martin","year":"2010","journal-title":"Iowa Orthop J"},{"issue":"03","key":"ref21","first-page":"985","article-title":"A rare tumor in a rare location: giant cell tumor of the sacrum and ilium - case report and current perspectives","volume":"60","author":"A Poll","year":"2019","journal-title":"Rom J Morphol Embryol"},{"issue":"03","key":"ref22","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/sj.sc.3100968","article-title":"Total spondylectomy for primary tumor of the thoracolumbar spine","volume":"38","author":"E Abe","year":"2000","journal-title":"Spinal Cord"},{"issue":"01","key":"ref23","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12957-019-1625-5","article-title":"Cervical spine giant cell bone tumor: a case report","volume":"17","author":"\u0130 Sertba\u015f","year":"2019","journal-title":"World J Surg Oncol"}],"container-title":["Journal of Neurological Surgery Part A: Central European Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2846-5029.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T22:41:23Z","timestamp":1786056083000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2846-5029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,26]]},"references-count":23,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2026,8,6]]},"published-print":{"date-parts":[[2026,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2846-5029","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2193-6315","2193-6323"],"issn-type":[{"value":"2193-6315","type":"print"},{"value":"2193-6323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,26]]}}}