{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:54:15Z","timestamp":1790898855750,"version":"4.1.0"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study aimed to evaluate the renal effects and safety of adjunct aminophylline therapy in neonates with hypoxic\u2013ischemic encephalopathy (HIE) undergoing therapeutic hypothermia (TH).<\/jats:p>\n                  <jats:p>This retrospective cohort study included neonates \u226536 weeks and &gt;2,000\u2009g diagnosed with HIE and treated with TH between May 2018 and January 2025. Infants were classified into two groups: those receiving TH alone (TH group) and those given a single intravenous 8\u2009mg\/kg dose of aminophylline at the initiation of cooling (TH\u2009+\u2009A group). Demographic, perinatal, and laboratory characteristics were collected, and serial serum creatinine (sCr) measurements at 24, 48, 72, and 96\u2009hours were analyzed to compare renal and clinical outcomes.<\/jats:p>\n                  <jats:p>A total of 297 infants were included (TH: 210; TH\u2009+\u2009A: 87). Baseline demographic and clinical characteristics were similar between the groups. While sCr values at each fixed time point did not significantly differ, repeated-measures analysis demonstrated a significantly steeper decline in sCr over time in the TH\u2009+\u2009A group (p\u2009&lt;\u20090.001). Convulsions were more frequent in the TH\u2009+\u2009A group (23.0 vs. 10.5%, p\u2009=\u20090.005), whereas mortality and other major clinical outcomes were comparable.<\/jats:p>\n                  <jats:p>Aminophylline administration at the start of TH was associated with a steeper decline in serum creatinine, suggesting a potential renoprotective effect in neonates with HIE. However, the higher frequency of convulsions emphasizes the need for careful neurological monitoring. Further studies are needed to clarify optimal dosing and the balance between potential renal benefits and neurological risks.<\/jats:p>","DOI":"10.1055\/a-2847-3290","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T22:34:41Z","timestamp":1775255681000},"page":"1935-1941","source":"Crossref","is-referenced-by-count":0,"title":["Renal Effects of Aminophylline in Cooled Neonates with Hypoxic\u2013Ischemic Encephalopathy"],"prefix":"10.1055","volume":"43","author":[{"given":"Osman","family":"Ba\u015ftu\u011f","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Health Sciences University, Kayseri City Hospital, Kayseri, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arife","family":"Canpolat","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Health Sciences University, Kayseri City Hospital, Kayseri, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek","family":"Kafadar","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Health Sciences University, Kayseri City Hospital, Kayseri, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Health Sciences University, Kayseri City Hospital, Kayseri, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Funda","family":"Ba\u015ftu\u011f","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology, Health Sciences University, Kayseri City Hospital, Kayseri, 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