{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T01:47:29Z","timestamp":1776908849505,"version":"3.51.2"},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJP Rep"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Introduction Myelomeningocele (MMC) is a type of open neural defect that involves exposure of the meninges and neural elements. There are fewer than 30 cases of twins with concordant MMCs reported in the literature. We discuss a case of dichorionic-triamniotic triplets in which the monochorionic-diamniotic pair was diagnosed antenatally with MMC.<\/jats:p>\n                  <jats:p>Case Summary The mother presented for routine prenatal care at 11 weeks of gestation as a 31-year-old G5P4003. A limited ultrasound at 18 weeks of gestation confirmed her estimated due date, and three viable fetuses were observed. She was found to have dichorionic-triamniotic triplets with Triplet A and Triplet B sharing a placenta. A detailed anatomic survey demonstrated MMC of Triplet B at L4-S2 and a suspected open neural tube defect in Triplet A. Triplet C had no apparent defects on ultrasound. MMC of Triplets A and B was confirmed postnatally. Chromosome microarray analyses for the triplets were normal.<\/jats:p>\n                  <jats:p>Discussion Most cases of MMC in monozygotic twins are nonconcordant, and the role of genetics remains ambiguous. Our case suggests a possible shared genetic etiology. Future studies may investigate the potential for a single-gene mutation driving the development of MMC.<\/jats:p>","DOI":"10.1055\/a-2848-3193","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T23:39:37Z","timestamp":1775605177000},"page":"e93-e95","source":"Crossref","is-referenced-by-count":0,"title":["Concordant Open Neural Tube Defects in a Monochorionic Twin Pair of a Dichorionic-Triamniotic Triplet Gestation"],"prefix":"10.1055","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9158-0416","authenticated-orcid":false,"given":"Olivia","family":"Van Benschoten","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, East Tennessee State University, Johnson City, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauryn","family":"Gabby","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, East Tennessee State University, Johnson City, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shreya","family":"Visvanathan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, East Tennessee State University, Johnson City, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashlyn","family":"Hodges","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, East Tennessee State University, Johnson City, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, East Tennessee State University, Johnson City, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, East Tennessee State University, Johnson City, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandr","family":"Fuks","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, East Tennessee State University, Johnson City, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2026,4,22]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1542\/peds.2009-2084","article-title":"Prevalence of spina bifida among children and adolescents in 10 regions in the United States","volume":"126","author":"M Shin","year":"2010","journal-title":"Pediatrics"},{"issue":"06","key":"ref2","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1159\/000511365","article-title":"Dual myelomeningoceles in twins: case report, review, and insights for etiology","volume":"55","author":"A Kobets","year":"2020","journal-title":"Pediatr Neurosurg"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/ddrr.93","article-title":"Epidemiologic and genetic aspects of spina bifida and other neural tube defects","volume":"16","author":"K S Au","year":"2010","journal-title":"Dev Disabil Res Rev"},{"issue":"11","key":"ref4","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1002\/ajmg.a.38472","article-title":"Mutations in folate transporter genes and risk for human myelomeningocele","volume":"173","author":"T O Findley","year":"2017","journal-title":"Am J Med Genet A"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1097\/01.GIM.0000151158.09278.2B","article-title":"Recurrence risks for neural tube defects in siblings of patients with lipomyelomeningocele","volume":"7","author":"C D Sebold","year":"2005","journal-title":"Genet Med"},{"issue":"10","key":"ref8","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/bdra.20511","article-title":"Further evidence for a maternal genetic effect and a sex-influenced effect contributing to risk for human neural tube defects","volume":"82","author":"K L Deak","year":"2008","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"04","key":"ref9","first-page":"885","article-title":"Mutational analysis of FOLR1 and FOLR2 genes in children with myelomeningocele","volume":"70","author":"N Hussain","year":"2023","journal-title":"Acta Biochim Pol"},{"issue":"02","key":"ref10","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/bdra.23538","article-title":"Maternal gene-micronutrient interactions related to one-carbon metabolism and the risk of myelomeningocele among offspring","volume":"109","author":"M P Nguyen","year":"2017","journal-title":"Birth Defects Res"},{"issue":"04","key":"ref11","first-page":"217","article-title":"Congenital malformations of the central nervous system. III. Risk of malformation in sibs of malformed individuals","volume":"4","author":"R G Record","year":"1950","journal-title":"Br J Soc Med"},{"issue":"05","key":"ref12","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1136\/jmg.13.5.343","article-title":"Spinal dysraphism: genetic relation to neural tube malformations","volume":"13","author":"C O Carter","year":"1976","journal-title":"J Med Genet"},{"issue":"04","key":"ref13","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s00381-018-3990-8","article-title":"Dizygotic opposite-sex twins with surgically repaired concordant myelomeningocele conceived by in vitro fertilization using intracytoplasmic sperm injection: a case report and review of the literature","volume":"35","author":"S Stricker","year":"2019","journal-title":"Childs Nerv Syst"},{"issue":"03","key":"ref14","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1093\/humrep\/16.3.504","article-title":"Congenital malformations in infants born after IVF: a population-based study","volume":"16","author":"A Ericson","year":"2001","journal-title":"Hum Reprod"},{"issue":"04","key":"ref15","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s10048-006-0052-2","article-title":"Current perspectives on the genetic causes of neural tube defects","volume":"7","author":"E Merello","year":"2006","journal-title":"Neurogenetics"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1093\/brain\/awm028","article-title":"Abnormal folate metabolism in foetuses affected by neural tube defects","volume":"130","author":"L PE Dunlevy","year":"2007","journal-title":"Brain"},{"issue":"11","key":"ref18","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1056\/NEJMoa1014379","article-title":"A randomized trial of prenatal versus postnatal repair of myelomeningocele","volume":"364","author":"N S Adzick","year":"2011","journal-title":"N Engl J Med"}],"container-title":["American Journal of Perinatology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2848-3193.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T01:31:15Z","timestamp":1776907875000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2848-3193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":15,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2026,4,7]]},"published-print":{"date-parts":[[2026,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2848-3193","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2157-6998","2157-7005"],"issn-type":[{"value":"2157-6998","type":"print"},{"value":"2157-7005","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,4,7]]},"published":{"date-parts":[[2026,4]]}}}