{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:46:51Z","timestamp":1789469211429,"version":"build-2803163510"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) is usually contraindicated in perforated cholecystitis, although initial reports suggest feasibility in contained perforation.<\/jats:p>\n                  <jats:p>This prospective single-center cohort study aimed to explore EUS-GBD outcomes in patients with acute cholecystitis with contained perforation (cp-AC; Niemeier classification type 2). A secondary exploratory comparison was performed with a contemporaneous cohort of patients with intact gallbladder walls.<\/jats:p>\n                  <jats:p>Between January 2021 and March 2025, 23 patients with cp-AC (39.7% of the overall EUS-GBD cohort) were enrolled. This subgroup showed high prevalence of underlying malignancy (87.0%) and previous endoscopic retrograde cholangiopancreatography with placement of metal stents (65.2%). Median operative space and interluminal distance were 30.5 mm (interquartile range [IQR] 26.0\u201337.0) and 5 mm (IQR 2\u20138), respectively. Technical and clinical success of EUS-GBD were 100% (95%CI 85.7\u2013100) and 87.0% (95%CI 67.9\u201395.5), respectively. The adverse event rate was 21.7% (95%CI 9.7\u201341.9) and did not differ significantly from that in the cohort with intact gallbladder walls; however, two fatal events occurred in the cp-AC group.<\/jats:p>\n                  <jats:p>EUS-GBD appeared to be technically feasible in patients with contained perforation, despite the additional complexity. However, this represents a particularly high-risk population, and the procedure may be considered only for carefully selected patients in expert centers.<\/jats:p>","DOI":"10.1055\/a-2848-3876","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T23:31:28Z","timestamp":1775172688000},"page":"882-887","source":"Crossref","is-referenced-by-count":1,"title":["Endoscopic ultrasound-guided gallbladder drainage in acute cholecystitis with contained perforation: a prospective cohort study"],"prefix":"10.1055","volume":"58","clinical-trial-number":[{"clinical-trial-number":"nct04813055","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7280-1761","authenticated-orcid":false,"given":"Giuseppe","family":"Vanella","sequence":"additional","affiliation":[{"name":"IRCCS San Raffaele Scientific Institute, Italy","place":["Milan"],"department":["Pancreatobiliary Endoscopy and Endosonography Division"]},{"name":"Vita-Salute San Raffaele University, Italy","place":["Milan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9597-6377","authenticated-orcid":false,"given":"Luc\u00eda","family":"Guilabert","sequence":"additional","affiliation":[{"name":"Dr. Balmis General University Hospital, Spain","place":["Alicante"],"department":["Instituto de Investigaci\u00f3n Sanitaria y Biom\u00e9dica de Alicante (ISABIAL)"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Frigo","sequence":"additional","affiliation":[{"name":"IRCCS San Raffaele Scientific Institute, Italy","place":["Milan"],"department":["Pancreatobiliary Endoscopy and Endosonography Division"]},{"name":"University of Turin, Italy","place":["Turin"],"department":["Postgraduate School of Gastroenterology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7945-1620","authenticated-orcid":false,"given":"Rosa 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