{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T22:55:24Z","timestamp":1781564124532,"version":"3.54.5"},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Epidermal growth factor plays an important role in cervical maturation and tissue\n                    remodeling during pregnancy. This study aimed to investigate the association\n                    between maternal serum epidermal growth factor levels measured at 37 weeks of\n                    gestation and late-term delivery. This single-center case\u2013control study was\n                    conducted at a tertiary maternity hospital. Low-risk pregnant women were\n                    enrolled, and high-risk pregnancies were excluded. Maternal blood samples were\n                    collected at 37 weeks of gestation prior to the onset of labor. Serum epidermal\n                    growth factor concentrations were measured using an enzyme-linked immunosorbent\n                    assay. Participants were classified according to the gestational age at delivery\n                    as late-term pregnancies or term controls. Demographic characteristics,\n                    obstetric outcomes, mode of delivery, neonatal outcomes, and serum epidermal\n                    growth factor levels were compared between groups. A total of 83 pregnant women\n                    were included, of whom 35 women delivered at the late term and 48 women\n                    delivered at term. The maternal age, body mass index, obstetric history, and\n                    Apgar scores did not differ significantly between groups. The gestational age at\n                    delivery and birth weight were significantly higher in the late-term group\n                        (p=0.001 and p=0.004, respectively). Cesarean delivery was\n                    more frequent among late-term pregnancies (70.8% vs 40%, p=0.005). Mean\n                    maternal serum epidermal growth factor levels were significantly lower in the\n                    late-term group compared with term controls (28.8\u00b19.8\u2009ng\/L vs 56.7\u00b127.3 ng\/l,\n                        p=0.005). Maternal serum epidermal growth factor levels measured at\n                    37 weeks of gestation were significantly lower in pregnancies resulting in\n                    late-term delivery. These findings suggest that altered epidermal growth factor\n                    regulation may be associated with prolonged gestation and delayed cervical\n                    maturation.<\/jats:p>","DOI":"10.1055\/a-2851-3634","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T22:48:17Z","timestamp":1779230897000},"page":"235-238","source":"Crossref","is-referenced-by-count":0,"title":["Maternal Serum Epidermal Growth Factor Levels at 37 Weeks of\n                    Gestation in Late-Term Pregnancies"],"prefix":"10.1055","volume":"58","author":[{"given":"Eseng\u00fcl","family":"T\u00fcrky\u0131lmaz \u015eener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Ulubasoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Necati","family":"Hancerliogullari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Ali","family":"Turgut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aytekin","family":"Tokmak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"ref2","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1186\/1471-2458-11-S3-S5","article-title":"Elective induction for pregnancies at or beyond 41 weeks of gestation and its\n                    impact on stillbirths: A systematic review with meta-analysis","volume":"11","author":"A A Hussain","year":"2011","journal-title":"BMC Public Health"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1210\/er.2003-0020","article-title":"Molecular cues to implantation","volume":"25","author":"S K Dey","year":"2004","journal-title":"Endocr Rev"},{"key":"ref4","first-page":"1362","article-title":"Gestational age-dependent dual action of epidermal growth factor on human\n                    placenta early in gestation","volume":"75","author":"T Maruo","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1071\/RD9951465","article-title":"Role of epidermal growth factor and its receptor in the development of the human\n                    placenta","volume":"7","author":"T Maruo","year":"1995","journal-title":"Reprod Fertil Dev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0002-9378(87)90245-6","article-title":"Epidermal growth factor deficiency during pregnancy causes abortion in mice","volume":"156","author":"O Tsutsumi","year":"1987","journal-title":"Am J Obstet Gynecol"},{"key":"ref7","first-page":"1","article-title":"The role of cytokines in the induction of labor, cervical ripening and rupture\n                    of the fetal membranes","volume":"200","author":"M Winkler","year":"1996","journal-title":"Z Geburtshilfe Neonatol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1186\/1756-0500-7-357","article-title":"Central role for protein kinase C in oxytocin- and epidermal growth\n                    factor-stimulated cyclooxygenase-2 expression in human myometrial cells","volume":"7","author":"E Wouters","year":"2014","journal-title":"BMC Res Notes"},{"key":"ref9","first-page":"e87467","article-title":"Role of the Bishop score in predicting successful induction of vaginal delivery:\n                    A systematic review of current evidence","volume":"17","author":"A Michail","year":"2025","journal-title":"Cureus"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0301-2115(98)00088-8","article-title":"Cervicovaginal fetal fibronectin concentrations: Predictive value of impending\n                    birth in postterm pregnancies","volume":"80","author":"R J Mouw","year":"1998","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"19685","DOI":"10.1038\/s41598-020-76753-4","article-title":"Relationship between cervical elastography and spontaneous onset of labor","volume":"10","author":"Y Yo","year":"2020","journal-title":"Sci Rep"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"155.e1","DOI":"10.1016\/j.ajog.2006.08.040","article-title":"Maternal obstetric complications of pregnancy are associated with increasing\n                    gestational age at term","volume":"196","author":"A B Caughey","year":"2007","journal-title":"Am J Obstet Gynecol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e1002838","DOI":"10.1371\/journal.pmed.1002838","article-title":"Risks of stillbirth and neonatal death with advancing gestation at term: A\n                    systematic review and meta-analysis of cohort studies","volume":"16","author":"J Muglu","year":"2019","journal-title":"PLoS Med"},{"key":"ref14","first-page":"175","article-title":"Postterm pregnancy","volume":"4","author":"M Galal","year":"2012","journal-title":"Facts Views Vis ObGyn"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1056\/NEJMra061360","article-title":"Parturition","volume":"356","author":"R Smith","year":"2007","journal-title":"N Engl J Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12964-021-00783-2","article-title":"EGF stimulates human trophoblast cell invasion by downregulating ID3-mediated\n                    KISS1 expression","volume":"19","author":"L Fang","year":"2021","journal-title":"Cell Commun Signal"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2851-3634.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T22:35:30Z","timestamp":1781562930000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2851-3634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,19]]},"references-count":15,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2026,6,15]]},"published-print":{"date-parts":[[2026,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2851-3634","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,19]]}}}