{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:16:37Z","timestamp":1790198197211,"version":"4.1.0"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["BIOQIC GRK2260,CRC1340 Matrix in Vision,CRC1470,CRC1540,FOR5628"],"award-info":[{"award-number":["BIOQIC GRK2260,CRC1340 Matrix in Vision,CRC1470,CRC1540,FOR5628"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008648","name":"Pfizer Foundation","doi-asserted-by":"crossref","award":["WP2487656"],"award-info":[{"award-number":["WP2487656"]}],"id":[{"id":"10.13039\/100008648","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002723","name":"Allianz Industrie Forschung","doi-asserted-by":"crossref","award":["FKZ KK5611902 BM4 \u201cMUSKEL\u201d"],"award-info":[{"award-number":["FKZ KK5611902 BM4 \u201cMUSKEL\u201d"]}],"id":[{"id":"10.13039\/501100002723","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Medical Scientist Pilot Program of the Charit\u00e9"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultraschall Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To introduce and validate optimized multifrequency cardiac time-harmonic elastography (THE) with portable drivers and multiple-heartbeat acquisitions for detecting abnormal diastolic stiffness using in silico testing and investigating participants with confirmed cardiac wild-type transthyretin amyloidosis (ATTRwt), a model disease for myocardial stiffness, compared to healthy controls.<\/jats:p>\n                  <jats:p>Cardiac THE was performed using continuous vibrations of 60, 70, and 80 Hz induced by a portable driver. Shear wave speed (SWS) maps, as a proxy for myocardial stiffness, were acquired over 4 seconds in a parasternal long axis view. Cardiac ultrasound simulations with CT-data-based anatomies were used for in silico validation and parameter optimization. Diagnostic performance was assessed using the area under the ROC curve (AUC) with 95% confidence interval (95%-CI).<\/jats:p>\n                  <jats:p>Healthy controls (N=10; median age: 32 years [range: 27\u201356]; five men) and participants with ATTRwt (N=11; median age: 83 years [range: 64\u201386]; ten men) were investigated, resulting in accurate amyloidosis detection (AUC: 1.00; 95%-CI: 0.94\u20131.00). In-silico-estimated SWS agreed with ground-truth values (r\u00b2=0.94; median error: 5.6% [range: \u201326.2\u201319.7]) across various stiffnesses [range: 1.3\u20134.0 m s\u20131] and thicknesses [range: 10\u201320 mm]. A trend towards underestimation was only observed in the unlikely scenario of thin and very stiff septa.<\/jats:p>\n                  <jats:p>For the first time, the accuracy of cardiac THE was quantified both in silico and in vivo, specifically in a cohort including patients with ATTRwt. Multifrequency shear waves induced by portable drivers and encoded in standard ultrasound provide a rapid, low-cost echocardiographic contrast that aids the detection of cardiomyopathies such as amyloidosis.<\/jats:p>","DOI":"10.1055\/a-2852-6188","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T23:07:58Z","timestamp":1775776078000},"source":"Crossref","is-referenced-by-count":1,"title":["Cardiac Multifrequency Time-harmonic Elastography: In Silico Validation and In Vivo Application"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6267-6354","authenticated-orcid":false,"given":"Stefan","family":"Klemmer Chand\u00eda","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Germany","place":["Berlin"],"department":["Department of 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Berlin"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Aghamiry","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Germany","place":["Berlin"],"department":["Department of Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Manini","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Germany","place":["Berlin"],"department":["Department of Radiology"]},{"name":"Deutsches Herzzentrum der Charit\u00e9, Germany","place":["Berlin"],"department":["Institute of Computer-Assisted Cardiovascular 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