{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T23:52:15Z","timestamp":1781653935700,"version":"3.54.5"},"reference-count":39,"publisher":"Georg Thieme Verlag KG","funder":[{"name":"Avtal om L\u00e4karutbildning och Forskning","award":["73810"],"award-info":[{"award-number":["73810"]}]},{"DOI":"10.13039\/501100005689","name":"G\u00f6teborgs L\u00e4kares\u00e4llskap","doi-asserted-by":"crossref","award":["1022557"],"award-info":[{"award-number":["1022557"]}],"id":[{"id":"10.13039\/501100005689","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rofo"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Differentiating malignant from benign peripheral nerve sheath tumors (PNSTs) is challenging due to overlapping imaging features. To develop and internally validate an MRI-based model to differentiate malignant from benign PNSTs and guide biopsy decisions.<\/jats:p>\n                  <jats:p>We retrospectively analyzed 139 consecutive adults with histologically proven PNSTs (121 benign, 18 malignant) discussed at a tertiary referral tumor board (2015\u20132024). Pre-treatment MRI examinations were independently assessed by two experienced musculoskeletal radiologists blinded to clinical and histopathological data. Based on prior knowledge and sample size limitations, a parsimonious logistic regression model was prespecified, including tumor volume, presence of a well-defined margin, and presence of cystic degeneration. Model performance was evaluated for discrimination, calibration, and clinical utility, with internal validation using 500 bootstrap resamples and uniform shrinkage.<\/jats:p>\n                  <jats:p>Malignant tumors were substantially larger, less often well-circumscribed, and more frequently cystic than benign lesions. The final three-predictor model demonstrated good discrimination (area under the curve [AUC] 0.944; optimism-corrected 0.936). At a 20% biopsy threshold, the model would prevent 68 unnecessary biopsies per 100 patients while missing three malignancies. Findings were robust in sensitivity analyses.<\/jats:p>\n                  <jats:p>A simple MRI-based model using three available features \u2013 tumor volume, margin definition, and cystic change \u2013 distinguished malignant from benign PNSTs with high accuracy. This proof-of-concept provides a practical framework for biopsy decision-making and merits external validation in multicenter cohorts.<\/jats:p>","DOI":"10.1055\/a-2852-8884","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:56:51Z","timestamp":1781650611000},"source":"Crossref","is-referenced-by-count":0,"title":["MRI-based prediction of malignancy in peripheral nerve tumors: model development and internal validation in a biopsy-confirmed cohort"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1963-7899","authenticated-orcid":false,"given":"Khaldun","family":"Ghali Gataa","sequence":"additional","affiliation":[{"name":"University of Gothenburg Sahlgrenska Academy, V\u00e4stra G\u00f6taland County, Sweden","place":["Gothenburg"],"department":["Radiology"]},{"name":"Sahlgrenska universitetssjukhuset, V\u00e4stra G\u00f6taland County, Sweden","place":["Gothenburg"],"department":["Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Dabrowska","sequence":"additional","affiliation":[{"name":"University of Gothenburg Sahlgrenska Academy, V\u00e4stra G\u00f6taland County, Sweden","place":["Gothenburg"],"department":["Radiology"]},{"name":"Sahlgrenska universitetssjukhuset, V\u00e4stra G\u00f6taland County, Sweden","place":["Gothenburg"],"department":["Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhamad","family":"Kader","sequence":"additional","affiliation":[{"name":"University of Gothenburg Sahlgrenska Academy, V\u00e4stra G\u00f6taland County, Sweden","place":["Gothenburg"],"department":["Radiology"]},{"name":"Sahlgrenska universitetssjukhuset, V\u00e4stra G\u00f6taland County, Sweden","place":["Gothenburg"],"department":["Neuro Psychiatry"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salwa","family":"Al-Saadi","sequence":"additional","affiliation":[{"name":"Sahlgrenska universitetssjukhuset, V\u00e4stra G\u00f6taland County, Sweden","place":["Gothenburg"],"department":["Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawel","family":"Szaro","sequence":"additional","affiliation":[{"name":"University of Gothenburg Sahlgrenska Academy, V\u00e4stra G\u00f6taland County, Sweden","place":["Gothenburg"],"department":["Radiology"]},{"name":"Sahlgrenska universitetssjukhuset, V\u00e4stra G\u00f6taland County, Sweden","place":["Gothenburg"],"department":["Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.carj.2010.04.009","article-title":"Pictorial Essay: Imaging of Peripheral Nerve Sheath Tumours","volume":"62","author":"DWY Chee","year":"2011","journal-title":"Canadian Association of Radiologists Journal"},{"key":"ref2","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-662-07859-4","volume-title":"Imaging of soft tissue tumors","author":"AMAd Schepper","year":"1997"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1148\/radiology.162.3.3101136","article-title":"Spinal and paraspinal neurofibromatosis: surface coil MR imaging at 1.5 T1","volume":"162","author":"DL Burk Jr.","year":"1987","journal-title":"Radiology"},{"key":"ref4","first-page":"825","article-title":"Benign solitary tumors of the peripheral nerves","volume":"86","author":"G Chick","year":"2000","journal-title":"Rev Chir Orthop Reparatrice Appar Mot"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1080\/02844310802489079","article-title":"Tumours of peripheral nerves in the upper extremity: a 22-year epidemiological study","volume":"43","author":"K Sandberg","year":"2009","journal-title":"Scand J Plast Reconstr Surg Hand Surg"},{"key":"ref6","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-030-77633-6","volume-title":"Diagnostic Assessment and Treatment of Peripheral Nerve Tumors","author":"F Guedes","year":"2021"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/BF00341943","article-title":"Extracranial and extraspinal nerve sheath tumors: computed tomographic evaluation","volume":"30","author":"MC Chui","year":"1988","journal-title":"Neuroradiology"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"141","DOI":"10.2214\/ajr.147.1.141","article-title":"Benign schwannomas: pathologic basis for CT inhomogeneities","volume":"147","author":"LM Cohen","year":"1986","journal-title":"AJR Am J Roentgenol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1002\/1097-0142(197301)31:13.0.co;2-8","article-title":"Malignant schwannoma. 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Verfahren"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2852-8884.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:56:53Z","timestamp":1781650613000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2852-8884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,16]]},"references-count":39,"URL":"https:\/\/doi.org\/10.1055\/a-2852-8884","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1438-9029","1438-9010"],"issn-type":[{"value":"1438-9029","type":"print"},{"value":"1438-9010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,16]]}}}