{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:52:39Z","timestamp":1785549159909,"version":"3.56.0"},"reference-count":34,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pneumologie"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Die Sepsis geh\u00f6rt zu den h\u00e4ufigsten Todesursachen im Krankenhaus und ist insbesondere in\n      der Pneumologie eine gro\u00dfe Herausforderung, da der Respirationstrakt in bis zu 50% der F\u00e4lle\n      den Fokus darstellt. In Deutschland entwickeln jedes Jahr rund 279.000 Patient*innen eine\n      Sepsis, und, je nach Datenquelle und Case Mix, versterben bis zu 40% der hospitalisierten\n      Patient*innen. Eine versp\u00e4tete Diagnosestellung verschlechtert die Prognose erheblich, weshalb\n      eine strukturierte Fr\u00fcherkennung, leitliniengerechte Therapie und konsequente\n      Qualit\u00e4tssicherung von zentraler Bedeutung sind.Die aktuelle Sepsis-3-Definition\n      beschreibt Sepsis als eine akut lebensbedrohliche Organdysfunktion, ausgel\u00f6st durch eine\n      inad\u00e4quate Wirtsantwort auf eine Infektion. Diagnostisch entscheidend ist ein Anstieg des\n      SOFA-Scores um mindestens 2 Punkte. Ein septischer Schock liegt vor, wenn trotz ad\u00e4quater\n      Volumengabe eine persistierende Hypotonie mit Laktatwerten \u00fcber 2 mmol\/l besteht und\n      Vasopressoren erforderlich sind.Seit 2026 wurde ein bundesweites\n      Qualit\u00e4tssicherungsverfahren eingef\u00fchrt, das Screeningraten, Antibiotikagabe, standardisierte\n      Behandlungsabl\u00e4ufe und Schulungen des medizinischen Personals erfasst. Ziel ist eine\n      fl\u00e4chendeckende Verbesserung der Fr\u00fcherkennung und Versorgung und damit die Senkung der\n      Mortalit\u00e4t bei Sepsis.F\u00fcr das Screening empfiehlt die 2025 erschienene \u00fcberarbeitete\n      S3-Leitlinie als Alternative zum qSOFA- den NEWS2-Score, der sich durch seine einfache\n      Anwendung und hohe Praxistauglichkeit etabliert hat, wobei beide im Rahmen des\n      Qualit\u00e4tssicherungsverfahrens als Screeninginstrument zugelassen sind. Zus\u00e4tzlich soll bei\n      Sepsisverdacht fr\u00fchzeitig der Laktatwert bestimmt werden.Die antiinfektive Therapie\n      beginnt mit der Entnahme von mindestens 2 Paar Blutkulturen vor Antibiotikagabe. Bei\n      septischem Schock sollte diese innerhalb der ersten Stunde, bei Sepsis ohne Schock sp\u00e4testens\n      nach 3 Stunden erfolgen.Die h\u00e4modynamische Stabilisierung erfolgt zun\u00e4chst durch die Gabe\n      von 30 ml\/kg (Standardk\u00f6rpergewicht) balancierter Kristalloide in den ersten 3 Stunden. Reicht\n      dies nicht aus, ist Noradrenalin das Mittel der Wahl.Besonders betont die Leitlinie die\n      Nachsorge von Sepsis\u00fcberlebenden. Patient*innen sollen fr\u00fchzeitig \u00fcber m\u00f6gliche Langzeitfolgen\n      wie das Post-Intensive-Care-Syndrom (PICS) informiert und durch strukturiertes\n      Entlassmanagement gezielt weiterbetreut werden.<\/jats:p>","DOI":"10.1055\/a-2853-3828","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T22:50:04Z","timestamp":1779231004000},"page":"522-530","source":"Crossref","is-referenced-by-count":1,"title":["Sepsis \u2013 Update 2026"],"prefix":"10.1055","volume":"80","author":[{"given":"Lina-Hanne Maria","family":"Ko","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Hamburg-Eppendorf, Deutschland","place":["Hamburg"],"department":["Klinik f\u00fcr Intensivmedizin"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Nierhaus","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Hamburg-Eppendorf, Deutschland","place":["Hamburg"],"department":["Klinik f\u00fcr Intensivmedizin"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Kluge","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Hamburg-Eppendorf, Deutschland","place":["Hamburg"],"department":["Klinik f\u00fcr Intensivmedizin"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"ref1","volume-title":"S3-Leitlinie: Sepsis \u2013 Pr\u00e4vention, Diagnose, Therapie und Nachsorge \u2013 Update 2025","author":"FM Brunkhorst","year":"2025"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s00063-025-01317-1","article-title":"S3-Leitlinie Sepsis \u2013\u00a0Pr\u00e4vention, Diagnose, Therapie und Nachsorge\u00a0\u2013 Update 2025","volume":"120","author":"FM Brunkhorst","year":"2025","journal-title":"Med Klin Intensivmed Notfmed"},{"key":"ref3","volume-title":"Beschluss des Gemeinsamen Bundesausschusses \u00fcber die prospektiven Rechenregeln f\u00fcr das Erfassungsjahr 2026 zum Verfahren 20: QS Sepsis der Richtlinie zur datengest\u00fctzten einrichtungs\u00fcbergreifenden Qualit\u00e4tssicherung (DeQS-RL)","author":"Gemeinsamer Bundesausschuss","year":"2025"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.1007\/s00134-018-5377-4","article-title":"Challenges in assessing the burden of sepsis and understanding the inequalities of sepsis outcomes between National Health Systems: secular trends in sepsis and infection incidence and mortality in Germany","volume":"44","author":"C Fleischmann-Struzek","year":"2018","journal-title":"Intensive Care Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990\u20132017: analysis for the Global Burden of Disease Study","volume":"395","author":"KE Rudd","year":"2020","journal-title":"The Lancet"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12175639","article-title":"Does Prehospital Suspicion of Sepsis Shorten Time to Administration of Antibiotics in the Emergency Department? 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