{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:09:18Z","timestamp":1779232158012,"version":"3.51.4"},"reference-count":61,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Extracorporeal membrane oxygenation (ECMO) has increasingly been used in patients with refractory severe cardiorespiratory failure in recent years. The use of ECMO necessitates anticoagulation as blood passes through an extracorporeal circuit that has a membrane lung and a centrifugal pump. Although heparin is the most common anticoagulant used during ECMO runs, other anticoagulants like direct thrombin inhibitors and Factor X inhibitors have also been implemented in special circumstances. Bleeding is a well-known and severe complication while receiving ECMO, and balancing this against circuit thrombosis is a clinical challenge. While standard laboratory tests, such as activated partial thromboplastin time and point-of-care tests such as activated clotting time, help monitor anticoagulation on ECMO, they have their drawbacks. The use of viscoelastic assays (VEAs) in aiding anticoagulation management on ECMO has shown some benefits in reducing bleeding and thrombotic complications, though these assays are not widely used at present. This article explores the challenges of monitoring anticoagulation on ECMO and reviews the available evidence regarding VEAs in adult and pediatric ECMO.<\/jats:p>","DOI":"10.1055\/a-2859-5556","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T23:07:00Z","timestamp":1776985620000},"source":"Crossref","is-referenced-by-count":0,"title":["Monitoring Hemostatic Function During Extracorporeal Membrane Oxygenation with Point-of-Care Viscoelastic Assays: A Narrative Review"],"prefix":"10.1055","author":[{"given":"Saikat","family":"Mitra","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, University Geelong Hospital, Barwon Health, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Low","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon","family":"Ong","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8335-7640","authenticated-orcid":false,"given":"Ryan Ruiyang","family":"Ling","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore"},{"name":"Australia and New Zealand Intensive Care Research Centre, School of Preventive Medicine and Public Health, Monash University, Melbourne, Victoria, Australia"},{"name":"Department of Anaesthesia, National University Hospital, National University Health System, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiran","family":"Shekar","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Caboolture Hospital, Brisbane, Queensland, Australia"},{"name":"Adult Intensive Care Services, The Prince Charles Hospital, Brisbane, Queensland, Australia"},{"name":"Bond University, Gold Coast, Queensland, Australia"},{"name":"Faculty of Health and Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graeme","family":"MacLaren","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore"},{"name":"Cardiothoracic Intensive Care Unit, Department of Cardiac, Thoracic and Vascular Surgery, National University Heart Centre, National University Health System, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4367-5182","authenticated-orcid":false,"given":"Bingwen Eugene","family":"Fan","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore"},{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore"},{"name":"Department of Hematology, Tan Tock Seng Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kollengode","family":"Ramanathan","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore"},{"name":"Cardiothoracic Intensive Care Unit, Department of Cardiac, Thoracic and Vascular Surgery, National University Heart Centre, National University Health System, 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