{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:04:40Z","timestamp":1784761480826,"version":"3.55.0"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In the drainage of peripancreatic fluid collections (PFCs), current practice recommends the removal of lumen-apposing metal stents (LAMSs) at 3\u20134 weeks, despite limited evidence. Many patients require longer indwell times (e.g. for serial necrosectomies or owing to logistical constraints). This study aimed to evaluate the incidence of adverse events (AEs) in patients undergoing PFC drainage with a LAMS, focusing on the timing of these events relative to the date of stent placement.<\/jats:p>\n                  <jats:p>A systematic review with meta-analysis of prospective studies evaluating the use of LAMSs in PFC drainage was conducted.<\/jats:p>\n                  <jats:p>Of the 1242 references identified, 15 studies, encompassing 662 patients, were included. From these studies, 128 AEs (19%; 95%CI 17% to 23%) were reported, with timing ascertainable in 122 cases (95%). The most frequently reported AEs were stent obstruction (n = 39; 32%, 95%CI 22% to 37%) and bleeding (n = 31; 25%, 95%CI 15% to 29%); 12 AEs (9%, 95%CI 6% to 18%) occurred during stent removal; 41 AEs (32%; 95%CI 25% to 42%) were classified as severe. Mortality associated with the LAMS was reported in 5\/662 cases (0.8%, 95%CI 0 to 2%). No association was found between stent indwell time and the incidence of AEs in the time\u2013event assessment. No association was observed regarding the publication year, type of collection, type of stent, or the use of cautery.<\/jats:p>\n                  <jats:p>In patients undergoing endoscopic ultrasound-guided drainage of PFCs, evidence suggests no significant association between LAMS indwell time and the incidence of AEs. This challenges rigid early removal policies and supports individualized, clinically driven timing, with structured follow-up and risk mitigation.<\/jats:p>","DOI":"10.1055\/a-2859-6615","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T22:40:56Z","timestamp":1779316856000},"page":"888-898","source":"Crossref","is-referenced-by-count":0,"title":["Stent indwell duration and adverse events in endoscopic ultrasound-guided lumen-apposing metal stent drainage of peripancreatic collections: systematic review and meta-analysis"],"prefix":"10.1055","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9607-157X","authenticated-orcid":false,"given":"Gustavo","family":"L\u00f3pez-Arce","sequence":"additional","affiliation":[{"name":"Hospital Angeles Centro Sur, Mexico","place":["Queretaro"],"department":["Gastroenterology and Endoscopy Department"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0401-0914","authenticated-orcid":false,"given":"Daniel","family":"Ruiz-Romero","sequence":"additional","affiliation":[{"name":"Hospital Angeles Acoxpa, Mexico","place":["Mexico City"],"department":["Gastroenterology and Gastrointestinal Endoscopy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar D.","family":"Borjas-Almaguer","sequence":"additional","affiliation":[{"name":"Christus Muguerza Hospital Systems, Mexico","place":["Balcones de Altavista-Monterrey"],"department":["Gastroenterology and Endoscopy Department"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6881-4148","authenticated-orcid":false,"given":"Isaac","family":"Bartnicki-Navarrete","sequence":"additional","affiliation":[{"name":"Hospital Angeles Acoxpa, Mexico","place":["Mexico City"],"department":["Gastroenterology and Gastrointestinal Endoscopy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge A.","family":"L\u00f3pez-Coss\u00edo","sequence":"additional","affiliation":[{"name":"Centro Medico Hospital del Prado SA de CV, Mexico","place":["Tijuana"],"department":["Gastroenterology and Digestive Endoscopy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Murcio-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Hospital de Especialidades Centro Medico Nacional Siglo XXI, Mexico","place":["Mexico city"],"department":["Endoscopy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0744-220X","authenticated-orcid":false,"given":"Manuel","family":"P\u00e9rez-Miranda","sequence":"additional","affiliation":[{"name":"Hospital Universitario Rio Hortega, Spain","place":["Valladolid"],"department":["Gastroenterology and Hepatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Blake","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences, Arkansas, United States","place":["Little Rock"],"department":["Division of Research and Evidence-Based Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e9lix I.","family":"T\u00e9llez-\u00c1vila","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences, Arkansas, United States","place":["Little Rock"],"department":["Gastroenterology and Hepatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.1136\/gutjnl-2016-312812","article-title":"Lumen-apposing metal stents (LAMS) for pancreatic fluid collection (PFC) drainage: may not be business as 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adverse events: analysis from a multicenter prospective case series","volume":"55","author":"S Bazaga","year":"2023","journal-title":"Endoscopy"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1055\/a-2342-1140","article-title":"A comparison of novel electrocautery-enhanced lumen-apposing metal stents and plastic stents in endoscopic ultrasound-guided drainage of infected walled-off necrosis: a multicenter randomized study","volume":"56","author":"JH Moon","year":"2024","journal-title":"Endoscopy"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1080\/00365521.2019.1710246","article-title":"Protocol of early lumen apposing metal stent removal for pseudocysts and walled off necrosis avoids bleeding complications","volume":"55","author":"W Ahmad","year":"2020","journal-title":"Scand J Gastroenterol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.cgh.2014.09.047","article-title":"Safety and efficacy of 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pancreatitis: A randomized controlled trial","volume":"21","author":"S Angadi","year":"2021","journal-title":"Pancreatology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/MCG.0000000000001545","article-title":"Electrocautery-enhanced lumen-apposing metal stents in the management of symptomatic pancreatic fluid collections: results from the multicenter prospective pivotal trial","volume":"57","author":"J Nieto","year":"2023","journal-title":"J Clin Gastroenterol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e1072","DOI":"10.1097\/SLA.0000000000005274","article-title":"Combined drainage and protocolized necrosectomy through a coaxial lumen-apposing metal stent for pancreatic walled-off necrosis: a prospective multicenter trial","volume":"277","author":"BKA Dayyeh","year":"2023","journal-title":"Ann Surg"},{"key":"ref19","article-title":"Self-expandable metal stent (SEMS) versus lumen-apposing metal stent (LAMS) for drainage of pancreatic 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Altonbary","year":"2017","journal-title":"Endoscopy"}],"container-title":["Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2859-6615.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T22:38:01Z","timestamp":1784759881000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2859-6615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,20]]},"references-count":29,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2026,7,22]]},"published-print":{"date-parts":[[2026,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2859-6615","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0013-726X","1438-8812"],"issn-type":[{"value":"0013-726X","type":"print"},{"value":"1438-8812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,20]]}}}