{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:01:46Z","timestamp":1785214906749,"version":"3.55.0"},"reference-count":11,"publisher":"Georg Thieme Verlag KG","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Das prim\u00e4re Sj\u00f6gren-Syndrom zeigt meist Sicca-Symptome, kann aber fr\u00fch unspezifische neurologische Beschwerden wie Migr\u00e4ne, Par\u00e4sthesien oder Schwindel verursachen.<\/jats:p>\n                  <jats:p>Eine 34-j\u00e4hrige Patientin klagte \u00fcber rezidivierende Kopfschmerzen, Schwindel und einmalige leichte Aphasie; zun\u00e4chst wurde Migr\u00e4ne ohne Aura diagnostiziert. Trotz stadiengerechter Therapie traten zus\u00e4tzliche Symptome wie Mund- und Augentrockenheit sowie Arthralgien auf.<\/jats:p>\n                  <jats:p>Die kranielle Bildgebung war unauff\u00e4llig. In einer Orbita-Dopplersonografie zeigten sich verbreiterte Optikus-Nervenscheiden. Bei der Autoimmunserologie waren ANA, ENA und Anti-SSA positiv. Schirmer-Test, Tr\u00e4nenfilm-Break-Up-Time und Speichelfluss best\u00e4tigten ein Sicca-Syndrom.<\/jats:p>\n                  <jats:p>Nach der Diagnosestellung wurde eine Therapie mit Prednisolon und Hydroxychloroquin eingeleitet, wodurch sich die neurologischen und extraglandul\u00e4ren Beschwerden deutlich besserten. Pilocarpin und eine begleitende Tr\u00e4nen- und Mundpflege verbesserten die Sicca-Symptome.<\/jats:p>\n                  <jats:p>Unspezifische neurologische Symptome k\u00f6nnen Fr\u00fchmanifestationen eines prim\u00e4ren Sj\u00f6gren-Syndroms sein, weshalb eine fr\u00fche serologische Abkl\u00e4rung und interdisziplin\u00e4re Diagnostik entscheidend sind.<\/jats:p>","DOI":"10.1055\/a-2861-0487","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T22:32:30Z","timestamp":1785191550000},"page":"843-846","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostisches Delay bei atypischer Migr\u00e4ne als Erstmanifestation eines prim\u00e4ren Sj\u00f6gren-Syndroms \u2013 ein Fallbericht"],"prefix":"10.1055","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7844-2763","authenticated-orcid":false,"given":"Tim","family":"Rabenhold","sequence":"additional","affiliation":[{"name":"Sanit\u00e4tsregiment 1, Zeitzer Str. 112, 06667 Wei\u00dfenfels"},{"name":"Universit\u00e4tsklinikum Halle, Ernst-Grube-Str. 40, 06120 Halle\/Saale"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp Georg","family":"Schnadthorst","sequence":"additional","affiliation":[{"name":"Bundeswehrkrankenhaus Hamburg, Lesserstr. 180, 22049 Hamburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Liebaug","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Halle, Ernst-Grube-Str. 40, 06120 Halle\/Saale"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"W\u00fcrzburg","sequence":"additional","affiliation":[{"name":"Sanit\u00e4tszentrum Bad Frankenhausen, Seeh\u00e4user Str. 60, 06567 Bad Frankenhausen\/Kyffh."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1186\/s13075-024-03404-8","article-title":"Patients\u2019 recollection about the onset of Sj\u00f6gren\u2019s disease \u2013 a mixed methods study on the patients\u2019 perspective","volume":"26","author":"A Lackner","year":"2024","journal-title":"Arthritis Res Ther"},{"issue":"01","key":"ref2","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/art.39859","article-title":"2016 ACR-EULAR Classification Criteria for primary Sj\u00f6gren\u2019s Syndrome: A Consensus and Data-Driven Methodology Involving Three International Patient Cohorts","volume":"69","author":"CH Shiboski","year":"2017","journal-title":"Arthritis Rheumatol"},{"issue":"02","key":"ref3","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s00296-024-05753-8","article-title":"al. 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