{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T12:32:45Z","timestamp":1793795565928,"version":"4.6.1"},"reference-count":16,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rofo"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study aimed to investigate morphological features on magnetic resonance cholangiopancreatography (MRCP) that may help distinguish benign from malignant causes of isolated main pancreatic duct (MPD) dilation detected without a visible mass or obstructive pathology, and to propose a management strategy applicable in clinical practice.<\/jats:p>\n                  <jats:p>Ninety-two patients with isolated MPD dilation detected on MRCP at our institution between November 2015 and March 2025 were retrospectively evaluated. The following MRCP parameters were assessed: maximum pancreatic duct diameter, location of dilation, dilation pattern, presence of duct stricture and stricture segment length with termination pattern if present, parenchymal atrophy, pancreatic duct anomalies, common bile duct\u2013pancreatic duct junction configurations, and presence of branch duct dilation or cysts.<\/jats:p>\n                  <jats:p>Cases were classified as benign in 85.9% (n=79) and malignant in 14.1% (n=13). Stricture segment length was significantly greater in the malignant group, with a median of 7.0 mm (Q1\u2013Q3: 5.0\u201312.0) compared to 3.7 mm (Q1\u2013Q3: 2.5\u20137.0) in the benign group. Although branch duct dilation\/cyst size was larger in the malignant group (median: 9.6 mm vs. 6.8 mm), this difference was not statistically significant (p &gt; 0.05). Regarding dilation location, the segment with maximum dilation was predominantly at the pancreatic neck in malignant cases (53.8%), whereas the pancreatic head was predominant in benign cases (88.6%). Stricture termination patterns differed significantly between groups: abrupt termination predominated in malignant cases (88.9%), while tapering termination was more frequent in the benign group (72.7%).<\/jats:p>\n                  <jats:p>MRCP is a valuable non-invasive tool for the further characterization of isolated MPD dilation. Findings such as increased stricture segment length (\u22657 mm), dilation localized to the pancreatic neck, and abrupt stricture termination may help distinguish malignant from benign causes. These morphological features may support clinical decision-making when determining the need for further invasive investigations.<\/jats:p>","DOI":"10.1055\/a-2863-2316","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T22:41:12Z","timestamp":1781044872000},"source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of MRCP Findings in Distinguishing Benign from Malignant Causes of Isolated Main Pancreatic Duct Dilation"],"prefix":"10.1055","author":[{"given":"Ece","family":"\u00c7\u0131nar","sequence":"additional","affiliation":[{"name":"Akdeniz University Faculty of Medicine, T\u00fcrkiye","place":["Antalya"],"department":["Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih Taha","family":"Uysal","sequence":"additional","affiliation":[{"name":"Akdeniz University Faculty of Medicine, T\u00fcrkiye","place":["Antalya"],"department":["Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet Faruk","family":"G\u00fcrb\u00fcz","sequence":"additional","affiliation":[{"name":"Akdeniz University Faculty of Medicine, T\u00fcrkiye","place":["Antalya"],"department":["Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1662-8586","authenticated-orcid":false,"given":"Ayse","family":"Keven","sequence":"additional","affiliation":[{"name":"Akdeniz University Faculty of Medicine, T\u00fcrkiye","place":["Antalya"],"department":["Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1148\/radiol.10100015","article-title":"Visually isoattenuating pancreatic adenocarcinoma at dynamic-enhanced CT: Frequency, clinical and pathologic characteristics, and diagnosis at imaging examinations","volume":"257","author":"J 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imaging investigation of age-related morphological changes in the pancreases of 226 Chinese","volume":"4","author":"L Wang","year":"2021","journal-title":"Aging Med (Milton)"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.giec.2023.03.001","article-title":"Burden of New Pancreatic Cyst Diagnosis","volume":"33","author":"S Romutis","year":"2023","journal-title":"Gastrointest Endosc Clin N Am"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.2214\/AJR.17.17963","article-title":"Isolated Main Pancreatic Duct Dilatation: CT Differentiation Between Benign and Malignant Causes","volume":"209","author":"S Kim","year":"2017","journal-title":"AJR Am J Roentgenol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.clinimag.2016.10.020","article-title":"Pancreatic duct stenosis: Differential diagnosis between malignant and benign conditions at secretin-enhanced MRCP","volume":"41","author":"E Boninsegna","year":"2017","journal-title":"Clin Imaging"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1148\/radiographics.20.4.g00jl23939","article-title":"MR cholangiopancreatography of bile and pancreatic duct abnormalities with emphasis on the single-shot fast spin-echo technique","volume":"20","author":"K Vitellas","year":"2000","journal-title":"Radiographics"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1007\/s00261-019-02292-w","article-title":"Pancreatitis and PDAC: Association and differentiation","volume":"45","author":"S Elsherif","year":"2020","journal-title":"Abdom Radiol (NY)"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"8285","DOI":"10.1007\/s00330-022-08928-8","article-title":"Assessment of main pancreatic duct cutoff with dilatation, but without visible pancreatic focal lesion on MDCT: A novel diagnostic approach for malignant stricture using a CT-based nomogram","volume":"32","author":"C Lim","year":"2022","journal-title":"Eur Radiol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1007\/s00330-014-3548-4","article-title":"Pancreatic duct \u201cIcicle sign\u201d on MRI for distinguishing autoimmune pancreatitis from pancreatic ductal adenocarcinoma in the proximal pancreas","volume":"25","author":"H Kim","year":"2015","journal-title":"Eur Radiol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1148\/radiol.2211001157","article-title":"Duct-penetrating sign at MRCP: Usefulness for differentiating inflammatory pancreatic mass from pancreatic carcinomas","volume":"221","author":"T Ichikawa","year":"2001","journal-title":"Radiology"}],"container-title":["R\u00f6Fo - Fortschritte auf dem Gebiet der R\u00f6ntgenstrahlen und der bildgebenden 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