{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:30:10Z","timestamp":1792092610741,"version":"4.4.0"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Plast Surg"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Lymphovenous anastomosis (LVA) has recently emerged as a potential method for the symptomatic management of Alzheimer's disease (AD). Building on this, we conceptualize the \u201cdynamic neck lymphovenous anastomosis\u201d (DN-LVA) to illustrate the versatility of our technique. DN-LVA utilizes a vein graft that traverses through the sternocleidomastoid muscle to facilitate the drainage of lymphatic fluid from the deep cervical lymphatic vessels to the external jugular vein.<\/jats:p>\n                  <jats:p>This study presents a retrospective analysis of patients who underwent DN-LVA between November 2024 and January 2025. The clinical outcome was evaluated through positron emission tomography\/computed tomography (PET\/CT) imaging and cognitive assessment tools, which included Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Neuropsychiatric Inventory (NPI), and Clinical Dementia Rating (CDR). The vein graft was harvested from the lower limb.<\/jats:p>\n                  <jats:p>Five subjects were recruited into this study. Postoperative PET\/CT scans revealed up to a 6.9% increase in glucose metabolism in patient 3, a decrease of 12.3% in amyloid deposits, and a 4.7% reduction in tau deposits in patient 5 and patient 4, respectively. Clinically, MMSE and MoCA scores were improved by 1.8 and 1.4, respectively. NPI scores decreased by 5.8 across five overall, and the CDR remained unchanged in all subjects. All grafts demonstrated vessel patency, and no postoperative complications were observed.<\/jats:p>\n                  <jats:p>DN-LVA appears to be a safe, minimally invasive procedure with potential cognitive and metabolic benefits in AD. Further studies with larger cohorts and longer follow-up are warranted to confirm these preliminary findings.<\/jats:p>","DOI":"10.1055\/a-2863-3797","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:26:59Z","timestamp":1777526819000},"page":"352-360","source":"Crossref","is-referenced-by-count":2,"title":["The Use of Dynamic Neck Lymphaticovenous Anastomosis in the Adjunctive Treatment of Alzheimer's Disease: A Retrospective Case Series"],"prefix":"10.1055","volume":"53","clinical-trial-number":[{"clinical-trial-number":"chictr2500104139","registry":"10.18810\/chictr"}],"author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3876-2462","authenticated-orcid":false,"given":"Xuhui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9466-7241","authenticated-orcid":false,"given":"Johnson","family":"Boey","sequence":"additional","affiliation":[{"name":"Department of Podiatry, SingHealth Duke-NUS Academic Medical Centre, Singapore, Singapore, Singapore"},{"name":"Department of Podiatric Medicine and Surgery, The University of Western Australia Faculty of Medicine Dentistry and Health Sciences, Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4135-3645","authenticated-orcid":false,"given":"Kou","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Hand Foot and Microsurgery Reconstruction Surgery, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3228-8585","authenticated-orcid":false,"given":"Chen","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Neurology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9797-4789","authenticated-orcid":false,"given":"Paloma","family":"Malag\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Hospital Germans Trias I Pujol, Universitat Aut noma de Barcelona, Badalona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6208-9704","authenticated-orcid":false,"given":"J. P.","family":"Hong","sequence":"additional","affiliation":[{"name":"Asan Medical Center, Department of Plastic Surgery, University of Ulsan, Seoul, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4402-581X","authenticated-orcid":false,"given":"Zhegang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Hand and Microsurgery Department, Peking University Shenzhen Hospital, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","article-title":"Alzheimer's disease","volume":"397","author":"P Scheltens","year":"2021","journal-title":"Lancet"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41572-021-00269-y","article-title":"Alzheimer disease","volume":"7","author":"D S 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