{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:41:57Z","timestamp":1792622517017,"version":"4.5.0"},"reference-count":11,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Gastroenterol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Die hepatische Enzephalopathie ist eine h\u00e4ufige Komplikation einer Leberzirrhose, welche standardm\u00e4\u00dfig mit Lactulose und Rifaximin sowie mit der Therapie ausl\u00f6sender Faktoren erfolgreich behandelt wird. Darunter ist die kognitive Symptomatik wie Verwirrtheit und Desorientierung in den meisten F\u00e4llen r\u00fcckl\u00e4ufig. Handelt es sich um eine therapierefrakt\u00e4re hepatische Enzephalopathie sollten jedoch weitere Differenzialdiagnosen in Betracht gezogen werden. Die erworbene hepatozerebrale Degeneration ist eine selten diagnostizierte Entit\u00e4t bei Patienten mit Leberzirrhose. Typischerweise haben die Patienten zus\u00e4tzlich zur kognitiven Dysfunktion eine extrapyramidal-motorische Symptomatik. Wir berichten \u00fcber einen 58-j\u00e4hrigen Patienten mit rezidivierenden therapierefrakt\u00e4ren enzephalopathischen Episoden, bei dem schlussendlich die Diagnose einer erworbenen hepatozerebralen Degeneration gestellt werden musste.<\/jats:p>","DOI":"10.1055\/a-2864-4075","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T22:57:22Z","timestamp":1780009042000},"page":"1486-1490","source":"Crossref","is-referenced-by-count":0,"title":["Therapierefrakt\u00e4re hepatische Enzephalopathie oder erworbene hepatozerebrale Degeneration \u2013 eine schwierige Differentialdiagnose"],"prefix":"10.1055","volume":"64","author":[{"given":"Vanessa","family":"Trentzsch","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Jena, Germany","place":["Jena"],"department":["Klinik f\u00fcr Gastroenterologie, Hepatologie, Infektiologie, Zentrale 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