{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:20:52Z","timestamp":1787959252722,"version":"build-2784847793"},"reference-count":13,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background Neurotrophic keratopathy (NK) is a rare, chronic corneal\n                    disorder resulting from impaired sensory innervation. Corneal neurotisation,\n                    which restores corneal innervation through nerve transfer, has emerged as a\n                    promising causal treatment approach. This retrospective study aimed to evaluate\n                    the clinical outcomes of corneal neurotisation in patients with NK.<\/jats:p>\n                  <jats:p>Material and Methods We retrospectively reviewed all patients who\n                    underwent indirect corneal neurotisation using an autologous sural nerve\n                    interposition graft for NK at the Eye Center at Medical Center, University\n                    Freiburg. Demographic characteristics, aetiology, postoperative corneal\n                    sensitivity, epithelial integrity, visual acuity, and complications were\n                    analysed descriptively.<\/jats:p>\n                  <jats:p>Results A total of four patients with Mackie stages 2 to 3 were included\n                    in the analysis. All developed measurable corneal sensitivity after surgery,\n                    whereas no sensitivity was present preoperatively. Complete corneal\n                    epithelialisation was achieved in every case, with no recurrent epithelial\n                    defects during follow-up (4\u200a\u2013\u200a49 months). No intraoperative or postoperative\n                    complications occurred. All patients reported subjective improvement, including\n                    reduced discomfort, keratitis, and recurrent erosions.<\/jats:p>\n                  <jats:p>Conclusion Indirect corneal neurotisation using an autologous sural nerve\n                    graft appears to be a safe and effective option for treating neurotrophic\n                    keratopathy. The procedure can restore corneal sensitivity, promote epithelial\n                    healing, and substantially alleviate symptoms, thereby improving patients\u02bc\n                    overall quality of life.<\/jats:p>","DOI":"10.1055\/a-2864-5774","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T23:03:17Z","timestamp":1782428597000},"source":"Crossref","is-referenced-by-count":0,"title":["Corneal Neurotisation in Neurotrophic Keratopathy: A\n                    Retrospective Analysis of Functional Outcomes and Clinical\n                    Courses"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5042-3135","authenticated-orcid":false,"given":"Patrick","family":"Thelen","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum\n                    Freiburg, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob B.W.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Plastische und Handchirurgie,\n                    Universit\u00e4tsklinikum Freiburg, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Reinhard","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum\n                    Freiburg, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolf Alexander","family":"Lagr\u00e8ze","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum\n                    Freiburg, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen U.","family":"Eisenhardt","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Plastische und Handchirurgie,\n                    Universit\u00e4tsklinikum Freiburg, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip Christian","family":"Maier","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum\n                    Freiburg, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1097\/icu.0000000000000578","article-title":"Corneal neurotization","volume":"30","author":"M Koaik","year":"2019","journal-title":"Curr Opin Ophthalmol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.jfo.2022.09.007","article-title":"Corneal neurotization in the management of neurotrophic keratopathy: A review of\n                    the literature","volume":"46","author":"S Saad","year":"2023","journal-title":"J Fr Ophtalmol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2214","DOI":"10.3390\/jcm12062214","article-title":"Corneal Neurotization\u2013Indications, Surgical Techniques and Outcomes","volume":"12","author":"D C Dragnea","year":"2023","journal-title":"J Clin Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1097\/sap.0000000000003117","article-title":"Corneal Neurotization: A Meta-analysis of Outcomes and Patient Selection\n                    Factors","volume":"88","author":"M A Swanson","year":"2022","journal-title":"Ann Plast Surg"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1097\/IOP.0000000000001583","article-title":"Corneal Neurotization: A Review of Pathophysiology and Outcomes","volume":"36","author":"J K Park","year":"2020","journal-title":"Ophthalmic Plast Reconstr Surg"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"4345","DOI":"10.1167\/iovs.18-24843","article-title":"Corneal Neurotization Improves Ocular Surface Health in a Novel Rat Model of\n                    Neurotrophic Keratopathy and Corneal Neurotization","volume":"59","author":"J Catapano","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1097\/IOP.0000000000001676","article-title":"Corneal Neurotization for Postherpetic Neurotrophic Keratopathy: Initial\n                    Experience and Clinical Outcomes","volume":"37","author":"J S Kim","year":"2021","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"101804","DOI":"10.1016\/j.ajoc.2023.101804","article-title":"Minimally invasive corneal neurotization for neurotrophic keratopathy: The\n                    potential effect of age, denervation chronicity and lesion location","volume":"29","author":"D SJ Ting","year":"2023","journal-title":"Am J Ophthalmol Case Rep"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1001\/jamaophthalmol.2014.2316","article-title":"Restoration of Corneal Sensation With Regional Nerve Transfers and Nerve Grafts:\n                    A New Approach to a Difficult Problem","volume":"132","author":"U Elbaz","year":"2014","journal-title":"JAMA Ophthalmol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.ajo.2022.04.013","article-title":"Minimally Invasive Corneal Neurotization Provides Sensory Function, Protects\n                    Against Recurrent Ulceration, and Improves Visual Acuity","volume":"241","author":"J H Woo","year":"2022","journal-title":"Am J Ophthalmol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1136\/bjophthalmol-2018-312563","article-title":"Corneal neurotisation by great auricular nerve transfer and scleral-corneal\n                    tunnel incisions for neurotrophic keratopathy","volume":"103","author":"N Jowett","year":"2019","journal-title":"Br J Ophthalmol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1097\/IOP.0000000000001181","article-title":"Minimally Invasive Corneal Neurotization With Acellular Nerve Allograft:\n                    Surgical Technique and Clinical Outcomes","volume":"35","author":"I M Leyngold","year":"2019","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1016\/j.bjps.2018.07.020","article-title":"Sensory and functional morbidity following sural nerve harvest in paediatric\n                    patients","volume":"71","author":"J Catapano","year":"2018","journal-title":"J Plast Reconstr Aesthetic Surg JPRAS"}],"container-title":["Klinische Monatsbl\u00e4tter f\u00fcr Augenheilkunde"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2864-5774.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:12:28Z","timestamp":1787958748000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2864-5774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":13,"URL":"https:\/\/doi.org\/10.1055\/a-2864-5774","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0023-2165","1439-3999"],"issn-type":[{"value":"0023-2165","type":"print"},{"value":"1439-3999","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,25]]}}}