{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T23:59:22Z","timestamp":1780963162413,"version":"3.54.1"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"CP","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Population-based data on outcomes of endoscopic retrograde cholangiopancreatography (ERCP) for benign indications are limited. We examined the impact of changing patient demographics on ERCP outcomes.<\/jats:p>\n                  <jats:p>Adults undergoing first ERCP for benign indications between 2003 and 2020 in England were identified in Hospital Episode Statistics. All-cause mortality within 30 days and adverse event rates within 7 days were calculated. Multivariable logistic regression analysis explored factors associated with all-cause mortality.<\/jats:p>\n                  <jats:p>A total of 283,972 patients were included; 63.4% female; median age 67 years (interquartile range 50\u201379). Twenty-five percent of ERCPs in 2019\/2020 were performed in patients with a Charlson comorbidity score \u2265 5, compared with 8% in 2003\/2004. Three percent of patients who underwent day case ERCP had an emergency readmission with pancreatitis. Thirty-day all-cause mortality fell by 31% over the study period. Mortality was associated with age (age quintile \u2265 82 years; odds ratio 19.22; 95% confidence interval [CI] 15.59\u201323.69 compared with 18\u201346 years), male sex (1.21; CI 1.14\u20131.27), Black or Black British ethnicity (1.42; CI 1.07\u20131.90), increasing comorbidity score \u2265 5 (3.35; CI 3.14\u20133.57), and increasing provider annual ERCP volume (volume \u2265 151; 1.08; CI 1.01\u20131.16). Elective ERCP (0.30; CI 0.28\u20130.33) and those in recent years were associated with lower mortality (2019\/2020 compared with 2003\/2004 (0.40; CI 0.34\u20130.48). Statistically significant variations in 30-day all-cause mortality were observed between ERCP providers.<\/jats:p>\n                  <jats:p>Despite the increasing age and comorbidities of patients undergoing ERCP for benign indications, 30-day all-cause mortality fell by 31% in recent years. All-cause mortality was associated with age, males, comorbidities, black ethnicity, emergency ERCP, and increasing provider volume.<\/jats:p>","DOI":"10.1055\/a-2865-3052","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T23:15:48Z","timestamp":1780960548000},"source":"Crossref","is-referenced-by-count":0,"special_numbering":"S","title":["All-cause mortality, adverse events and associated factors following endoscopic retrograde cholangiopancreatography for benign indications in England"],"prefix":"10.1055","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6531-9205","authenticated-orcid":false,"given":"Umair","family":"Kamran","sequence":"first","affiliation":[{"name":"Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom of Great Britain and Northern Ireland","place":["Newcastle Upon Tyne"],"department":["HPB Unit and Department of Gastroenterology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip R.","family":"Harvey","sequence":"first","affiliation":[{"name":"Royal Wolverhampton Hospitals NHS Trust, United Kingdom of Great Britain and Northern Ireland","place":["Wolverhampton"],"department":["Department of Gastroenterology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Coupland","sequence":"additional","affiliation":[{"name":"University Hospitals Birmingham NHS Foundation Trust, England, United Kingdom of Great Britain and Northern Ireland","place":["Birmingham"],"department":["Department of Health Informatics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jemma","family":"Mytton","sequence":"additional","affiliation":[{"name":"University Hospitals Birmingham NHS Foundation Trust, England, United Kingdom of Great Britain and Northern Ireland","place":["Birmingham"],"department":["Department of Health Informatics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7381-7412","authenticated-orcid":false,"given":"Kofi W.","family":"Oppong","sequence":"additional","affiliation":[{"name":"Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom of Great Britain and Northern Ireland","place":["Newcastle Upon Tyne"],"department":["HPB Unit and Department of Gastroenterology"]},{"name":"Newcastle University, England, United Kingdom of Great Britain and Northern Ireland","place":["Newcastle upon Tyne"],"department":["Institute of Translational and Clinical Research"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Trudgill","sequence":"additional","affiliation":[{"name":"Sandwell and West Birmingham NHS Trust, United Kingdom of Great Britain and Northern Ireland","place":["West Bromwich"],"department":["Department of Gastroenterology"]},{"name":"University of Birmingham, England, United Kingdom of Great Britain and Northern Ireland","place":["Birmingham"],"department":["Department of Cancer and Genomic Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1111\/j.1572-0241.2007.01279.x","article-title":"Incidence rates of post-ERCP complications: a systematic survey of prospective studies","volume":"102","author":"A Andriulli","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/j.bpg.2016.10.007","article-title":"Complications of ERCP","volume":"30","author":"R Talukdar","year":"2016","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1055\/s-2007-966723","article-title":"Risk factors for complication following ERCP; 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