{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:07:51Z","timestamp":1779408471884,"version":"3.53.1"},"reference-count":42,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Antiphospholipid syndrome (APS) is an autoimmune disease defined by thrombotic or obstetrical clinical manifestations and the persistent presence of antiphospholipid antibodies, including lupus anticoagulant, anticardiolipin antibodies, and anti-\u03b22-glycoprotein I antibodies. Obstetric APS (OAPS) is associated with pregnancy morbidity, including early recurrent pregnancy loss (RPL), preeclampsia, premature birth, and stillbirth. Treatment regimens for women with OAPS are designed to optimize pregnancy outcomes. It is still debated which intervention results in the most optimal pregnancy outcome. This scoping review examines treatment options for women with OAPS presenting with RPL based solely on randomized controlled trials (RCTs) reporting pregnancy outcomes. A systematic search identified 1,234 studies published up to January 2026, from which 14 RCTs met the inclusion criteria: pregnant women with APS defined as persistent aPL positivity and RPL (\u22652) receiving therapeutic intervention with live birth as the primary outcome. These RCTs, published between 1992 and 2017, included 1,878 participants. Secondary outcomes, including birth weight, preeclampsia, preterm delivery, and bleeding, were also analyzed. Different treatment options such as low-dose aspirin (LDA), unfractionated heparin, low molecular weight heparin (LMWH), corticosteroids, and intravenous immunoglobulin were used in the clinical trials. Antithrombotic therapy (LDA\u2009+\u2009LMWH) was associated with higher live birth rates compared with the other evaluated strategies. However, this finding is based on a small number of heterogeneous RCTs and is disproportionately driven by a single large trial. Consequently, substantial uncertainty remains. High-quality, adequately powered RCTs are urgently needed to provide robust evidence for optimal OAPS management.<\/jats:p>","DOI":"10.1055\/a-2866-2950","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T23:10:13Z","timestamp":1778022613000},"source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic Interventions for Obstetric Antiphospholipid Syndrome Associated with Recurrent Pregnancy Loss: A Scoping Review of Randomized Controlled Trials on Live Birth Outcomes"],"prefix":"10.1055","author":[{"given":"Buse","family":"Bor","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Central Denmark Region, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University, Aarhus, Central Denmark Region, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Danish Center for Expertise in Rheumatology (CeViG), Danish Hospital for Rheumatic Diseases S\u00f8nderborg, S\u00f8nderborg, Denmark"},{"name":"Institute for Regional Health, Southern Danish University, Odense, Denmark"},{"name":"Department of Thrombosis and Haemostasis, Guy's and St Thomas' NHS Foundation Trust, London, England, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bent Winding","family":"Deleuran","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Aarhus University Hospital, Aarhus, Central Denmark Region, Denmark"},{"name":"Institute of Biomedicine, Aarhus University, Aarhus, Central Denmark Region, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa Vakur","family":"Bor","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, University Hospital of Southern Denmark, Esbjerg, Denmark"},{"name":"Unit for Thrombosis Research, Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1538-7836.2006.01753.x","article-title":"International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)","volume":"4","author":"S Miyakis","year":"2006","journal-title":"J Thromb Haemost"},{"issue":"08","key":"ref2","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.3390\/jcm11082164","article-title":"Laboratory diagnosis of antiphospholipid syndrome: insights and hindrances","volume":"11","author":"A Vandevelde","year":"2022","journal-title":"J Clin Med"},{"issue":"10","key":"ref3","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1002\/art.42624","article-title":"The 2023 ACR\/EULAR antiphospholipid syndrome classification 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