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Traditionally, it is still used to treat\n                    gastrointestinal disorders, liver\/bile diseases, respiratory ailments, and skin\n                    disorders. This review presents, for the first time, an in-depth examination of\n                    ethnopharmacology, phytochemistry, botany, safety of use, biological activity,\n                    and non-medical aspects associated with ground ivy. The data were extracted\n                    through detailed probing of key databases, including PubMed, Web of Science,\n                    Scopus, and SciFinder. In addition, books, papers from conference proceedings,\n                    and websites were used. This study reveals that compounds belonging to various\n                    classes, including phenolic acids, flavonoids, lignans, alkaloids, and\n                    terpenoids, have been identified. Crude extracts, fractions, and some individual\n                    compounds have shown various pharmacological activities, including\n                    hepatoprotective, anti-inflammatory, antioxidant, anticancer, and\n                    melanogenesis-modulating effects. Apart from its value in phytotherapy, G.\n                        hederacea also shows potential as a natural pesticide and stabilizing\n                    agent in the food industry. The traditional medicinal uses of the ground ivy,\n                    combined with modern scientific research, underscore its pharmacological\n                    potential. However, future studies should incorporate relevant animal\n                    experiments and clinical studies to provide a more comprehensive assessment of\n                    the efficacy and bioavailability. Although there is a rich literature on\n                    secondary metabolites detected in G. hederacea, it seems right to fill in\n                    which compounds are determinants of a given activity. Finally, research on using\n                        G. hederacea as a natural pesticide, which could lead to its\n                    implementation, warrants further investigation.<\/jats:p>","DOI":"10.1055\/a-2866-3799","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T22:44:32Z","timestamp":1779489872000},"page":"1072-1135","source":"Crossref","is-referenced-by-count":1,"title":["Glechoma hederacea: A Comprehensive Insight into the Botanical\n                    Specification, Traditional Uses, Phytochemistry, Nutritional Value,\n                    Pharmacology, and Non-medicinal Applications"],"prefix":"10.1055","volume":"92","author":[{"given":"Weronika","family":"Krasocka","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Medical University of\n                    Lodz, Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika Anna","family":"Olszewska","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Medical University of\n                    Lodz, Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2437-3242","authenticated-orcid":false,"given":"Anna","family":"Magiera","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Medical University of\n                    Lodz, Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s13237-022-00405-3","article-title":"Plant-derived natural products for drug discovery: Current approaches and\n                    prospects","volume":"65","author":"N Nasim","year":"2022","journal-title":"Nucleus"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"5755","DOI":"10.1002\/ptr.8019","article-title":"Plants with cosmetic uses","volume":"37","author":"K Mansoor","year":"2023","journal-title":"Phytother Res"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"3266","DOI":"10.3390\/ijms24043266","article-title":"A comprehensive review on the biological, agricultural and pharmaceutical\n                    properties of secondary metabolites based-plant origin","volume":"24","author":"H S Elshafie","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref4","first-page":"135","volume-title":"Phytochemical and Pharmacological Importance of Plant Secondary Metabolites in\n                    Modern Medicine","author":"G Velu","year":"2018"},{"key":"ref6","first-page":"316","volume-title":"Syllabus der Pflanzenfamilien","author":"A Engler","year":"1912"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1080\/11263504.2020.1727981","article-title":"Morphological plasticity and ecophysiological response of ground ivy\n                        (Glechoma hederacea, Lamiaceae) in contrasting natural habitats\n                    within its native range","volume":"155","author":"M Sipek","year":"2021","journal-title":"Plant Biosyst"},{"key":"ref9","first-page":"2373","volume-title":"Dicotyledones. Sympetalae. Illustrierte Flora von Mittel-Europa, Vol. V\u20134","author":"G Hegi","year":"1927"},{"key":"ref10","first-page":"102","volume-title":"Ro\u015bliny lecznicze i ich praktyczne zastosowanie","author":"A O\u017carowski","year":"1987"},{"key":"ref11","first-page":"65","volume-title":"Kompendium fitoterapii dla lekarzy i farmaceut\u00f3w oraz student\u00f3w medycyny","author":"L Samochowiec","year":"1995"},{"key":"ref12","first-page":"165","volume-title":"Ro\u015bliny lecznicze","author":"J Vol\u00e1k","year":"1992"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"113830","DOI":"10.1016\/j.jep.2021.113830","article-title":"A review of plant characteristics, phytochemistry and bioactivities of the genus\n                        Glechoma","volume":"271","author":"Y Zhou","year":"2021","journal-title":"J Ethnopharmacol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1016\/j.foodres.2011.03.030","article-title":"Encapsulation of polyphenolic antioxidants from medicinal plant extracts in\n                    alginate\u2013chitosan system enhanced with ascorbic acid by electrostatic\n                    extrusion","volume":"44","author":"A Bel\u0161\u010dak-Cvitanovi\u0107","year":"2011","journal-title":"Food Res Int"},{"key":"ref15","first-page":"10","volume-title":"Encapsulation of Ground Ivy (Glechoma hederacea L.) extract, obtained by\n                    natural deep eutectic solvents extraction, in liposomes. 10th International\n                    Congress of Food Technologists, Biotechnologists and Nutritionists","author":"B Balan\u010d","year":"2022"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"109658","DOI":"10.1016\/j.foodhyd.2023.109658","article-title":"Effect of guar gum-based carriers on the physical and bioactive properties of\n                    spray-dried delivery systems of ground ivy (Glechoma hederacea L.)","volume":"150","author":"D \u0160eremet","year":"2024","journal-title":"Food Hydrocoll"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.3390\/foods11121816","article-title":"Development, characterization and incorporation of alginate-plant protein\n                    covered liposomes containing ground ivy (Glechoma hederacea L.) extract\n                    into candies","volume":"11","author":"D \u0160eremet","year":"2022","journal-title":"Foods"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1590\/S1516-05722013000300007","article-title":"Selection of active plant extracts against the coffee leaf miner Leucoptera\n                        coffeella (Lepidoptera: Lyonetiidae)","volume":"15","author":"D S Alves","year":"2013","journal-title":"Rev Bras Plantas Med"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3390\/agriculture14010058","article-title":"Suppressive activity of Glechoma hederacea extracts against the\n                    phytopathogenic oomycete Plasmopara viticola, and first screening of the\n                    active metabolites","volume":"14","author":"J G Zorrilla","year":"2023","journal-title":"Agriculture"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1177\/1934578X1000500116","article-title":"Antioxidant effects of Glechoma hederacea as a food additive","volume":"5","author":"M Milovanovic","year":"2010","journal-title":"Nat Prod Commun"},{"key":"ref21","first-page":"275","volume-title":"Diversity and Classification of Flowering Plants: Eudicots","author":"M G Simpson","year":"2010","edition":"2nd edition"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1046\/j.1365-2745.1999.00358.x","article-title":"Glechoma hederacea L. 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