{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:07:43Z","timestamp":1779232063347,"version":"3.51.4"},"reference-count":12,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pneumologie"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Malignant pleural mesothelioma (MPM) is a rare and aggressive neoplasm with limited long-term survival. We report a case of a 72-year-old woman diagnosed with epithelioid MPM and NF2 mutation in 2018, who presented with a solitary adrenal metastasis six years after initial diagnosis. After initial surgery and chemotherapy, disease progressed within one year. Immunotherapy with ipilimumab and nivolumab resulted in long-term disease control. This case highlights an exceptionally delayed metachronous adrenal metastasis and prolonged survival under sustained immunotherapy.<\/jats:p>","DOI":"10.1055\/a-2867-9892","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T22:50:04Z","timestamp":1779231004000},"source":"Crossref","is-referenced-by-count":0,"title":["Delayed Solitary Adrenal Metastasis in Malignant Pleural Mesothelioma with Long-Term Survival under Immunotherapy"],"prefix":"10.1055","author":[{"given":"Maximilian","family":"Franke","sequence":"additional","affiliation":[{"name":"Helios Clinic Emil von Behring, Germany","place":["Berlin"],"department":["Respiratory Diseases Clinic Heckeshorn"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halil Ibrahim","family":"Toy","sequence":"additional","affiliation":[{"name":"Helios Clinic Emil von Behring, Germany","place":["Berlin"],"department":["Respiratory Diseases Clinic Heckeshorn"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Misch","sequence":"additional","affiliation":[{"name":"Helios Clinic Emil von Behring, Germany","place":["Berlin"],"department":["Respiratory Diseases Clinic Heckeshorn"]},{"name":"Berlin Lung Institute, Germany","place":["Berlin"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susann","family":"Stephan-Falkenau","sequence":"additional","affiliation":[{"name":"Helios Klinikum Emil von Behring, Germany","place":["Berlin"],"department":["Department of Tissue Diagnostics"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Jansen","sequence":"additional","affiliation":[{"name":"Helios Clinic Emil von Behring, Germany","place":["Berlin"],"department":["Clinic of General, Abdominal and Minimally Invasive Surgery"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1275-7361","authenticated-orcid":false,"given":"Torsten","family":"Bauer","sequence":"additional","affiliation":[{"name":"Helios Clinic Emil von Behring, Germany","place":["Berlin"],"department":["Respiratory Diseases Clinic Heckeshorn"]},{"name":"Berlin Lung Institute, Germany","place":["Berlin"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Kollmeier","sequence":"additional","affiliation":[{"name":"Berlin Lung Institute, Germany","place":["Berlin"]},{"name":"Helios Clinic Emil von Behring, Germany","place":["Berlin"],"department":["Respiratory Diseases Clinic Heckeshorn"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1900953","DOI":"10.1183\/13993003.00953-2019","article-title":"ERS\/ESTS\/EACTS\/ESTRO guidelines for the management of malignant pleural mesothelioma","volume":"55","author":"A Scherpereel","year":"2020","journal-title":"Eur Respir J"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1183\/16000617.0063-2016","article-title":"Malignant pleural mesothelioma: an update on investigation, diagnosis and treatment","volume":"25","author":"AC Bibby","year":"2016","journal-title":"Eur Respir Rev"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1097\/MCP.0000000000000258","article-title":"Pleural biopsies in undiagnosed pleural effusions; 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