{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:03:33Z","timestamp":1781222613048,"version":"3.54.1"},"reference-count":10,"publisher":"Georg Thieme Verlag KG","funder":[{"name":"Ensign Endowment for Gynecologic Cancer Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A recent analysis of the Centers for Disease Control and Prevention's National Vital Statistics System found that pregnant people with tobacco use disorder have decreased in the United States. To further validate their findings in a different data source, this study assessed the temporal trends of pregnant people with tobacco use disorder in the Agency for Healthcare Research and Quality's data source.<\/jats:p>\n                  <jats:p>This cross-sectional study queried the Healthcare Cost and Utilization Project's National Inpatient Sample. The study population included 24,976,627 hospital deliveries from 2016 to 2022. Prevalence rates of pregnant people with a diagnosis of tobacco use disorder were summarized in each year. A multivariable generalized linear model was created to assess the temporal trend, adjusting for maternal age, race\/ethnicity, primary payer, census-level median household income, region, other substance use disorder, and mental health disorder.<\/jats:p>\n                  <jats:p>A total of 1,237,415 (5.0%) hospital deliveries had a diagnosis of tobacco use disorder. Annualized prevalence rate of tobacco use disorder decreased by 27.3% from 5.5% in 2016 to 4.0% in 2022 over the 7-year study period (adjusted-prevalence rate ratio [aRR] for 2022 compared with 2016, 0.72, 95% confidence interval [CI]: 0.71\u20130.72). The relative-decrease from 2016 to 2022 in tobacco use disorder was particularly high among younger (age\u2009&lt;\u200925, 7.1% in 2016 to 4.7% in 2022, aRR: 0.63, 95% CI: 0.62\u20130.64; and age 25\u201329, 6.3% in 2016 to 4.3% in 2022, aRR: 0.67, 95% CI: 0.67\u20130.68), those in New England (5.2% in 2016 to 3.2% in 2022, aRR: 0.67, 95% CI: 0.65\u20130.70), Mid-Atlantic (4.9% in 2016 to 3.3% in 2022, aRR: 0.65, 95% CI: 0.64\u20130.66), and East North Central (8.4% in 2016 to 6.0% in 2022, aRR: 0.69, 95% CI: 0.68-0.70), and those with mental health condition (anxiety disorder, 15.9% in 2016 to 8.5% in 2022, aRR: 0.62, 95% CI: 0.61\u20130.64; and depressive disorder, 16.4% in 2016 to 9.6% in 2022, aRR: 0.66, 95% CI: 0.65\u20130.68).<\/jats:p>\n                  <jats:p>This national-level assessment externally validated a prior study that pregnant people with tobacco use disorder have decreased in the United States. A nearly 30% decrease over a 7-year period is clinically significant and encouraging.<\/jats:p>","DOI":"10.1055\/a-2869-5340","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T22:51:37Z","timestamp":1778712697000},"source":"Crossref","is-referenced-by-count":0,"title":["Decreasing Trends of Tobacco Use Disorder among Pregnant People in the United States"],"prefix":"10.1055","author":[{"given":"Jennifer A.","family":"Yao","sequence":"additional","affiliation":[{"name":"University of Southern California, United States","department":["Keck School of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelina E.","family":"Lim","sequence":"additional","affiliation":[{"name":"University of Southern California, United States","department":["Keck School of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoi","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Osaka University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian E.","family":"Hong","sequence":"additional","affiliation":[{"name":"The Los Angeles General Medical Center, United States","department":["Department of Obstetrics and Gynecology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sawa","family":"Keymeulen","sequence":"additional","affiliation":[{"name":"The Los Angeles General Medical Center, United States","department":["Department of Obstetrics and Gynecology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph G.","family":"Ouzounian","sequence":"additional","affiliation":[{"name":"Keck School of Medicine, University of Southern California, United States","department":["Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6232-8701","authenticated-orcid":false,"given":"Koji","family":"Matsuo","sequence":"additional","affiliation":[{"name":"The Los Angeles General Medical Center, United States","department":["Department of Obstetrics and Gynecology"]},{"name":"University of Southern California, United States","department":["Division of Gynecologic Oncology, Department of Obstetrics and Gynecology"]},{"name":"University of Southern California, United States","department":["Norris Comprehensive Cancer Center"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"issue":"08","key":"ref1","doi-asserted-by":"crossref","first-page":"e1003158","DOI":"10.1371\/journal.pmed.1003158","article-title":"Maternal cigarette smoking before and during pregnancy and the risk of preterm birth: a dose-response analysis of 25 million mother-infant pairs","volume":"17","author":"B Liu","year":"2020","journal-title":"PLoS Med"},{"issue":"24","key":"ref2","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1080\/14767058.2016.1271405","article-title":"Smoking and placenta previa: a meta-analysis","volume":"30","author":"F Shobeiri","year":"2017","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"08","key":"ref3","doi-asserted-by":"crossref","first-page":"e2224701","DOI":"10.1001\/jamanetworkopen.2022.24701","article-title":"Association of maternal tobacco use during pregnancy with preadolescent brain morphology among offspring","volume":"5","author":"R Zou","year":"2022","journal-title":"JAMA Netw Open"},{"issue":"09","key":"ref4","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1002\/pd.5660","article-title":"The impact of tobacco chemicals and nicotine on placental development","volume":"40","author":"M A Suter","year":"2020","journal-title":"Prenat Diagn"},{"issue":"02","key":"ref5","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/GRF.0000000000000699","article-title":"Pregnancy outcomes associated with use of tobacco and marijuana","volume":"65","author":"V Layoun","year":"2022","journal-title":"Clin Obstet Gynecol"},{"issue":"458","key":"ref6","first-page":"1","article-title":"Declines in cigarette smoking during pregnancy in the United States, 2016-2021","author":"J A Martin","year":"2023","journal-title":"NCHS Data Brief"},{"issue":"11","key":"ref8","doi-asserted-by":"crossref","first-page":"e2242842","DOI":"10.1001\/jamanetworkopen.2022.42842","article-title":"Association of pregnancy characteristics and maternal mortality with amniotic fluid embolism","volume":"5","author":"G R Mazza","year":"2022","journal-title":"JAMA Netw Open"},{"issue":"04","key":"ref9","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.chest.2017.06.033","article-title":"Prevention and treatment of smoking and tobacco use during pregnancy in selected indigenous communities in high-income countries of the United States, Canada, Australia, and New Zealand: an evidence-based review","volume":"152","author":"G S Gould","year":"2017","journal-title":"Chest"},{"issue":"05","key":"ref10","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/ntr\/ntac240","article-title":"Smoking behaviors among indigenous pregnant people compared to a matched regional cohort","volume":"25","author":"A M Rusk","year":"2023","journal-title":"Nicotine Tob Res"},{"issue":"01","key":"ref11","doi-asserted-by":"crossref","first-page":"e2020040253","DOI":"10.1542\/peds.2020-040253","article-title":"Health disparities in tobacco use and exposure: a structural competency approach","volume":"147","author":"J Marbin","year":"2021","journal-title":"Pediatrics"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2869-5340.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T23:26:04Z","timestamp":1781220364000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2869-5340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,13]]},"references-count":10,"URL":"https:\/\/doi.org\/10.1055\/a-2869-5340","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,13]]}}}