{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T23:57:26Z","timestamp":1781135846274,"version":"3.54.1"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2023YFC3604803"],"award-info":[{"award-number":["2023YFC3604803"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Key Project of Yuanshen Rehabilitation Institute, Shanghai Jiao Tong University School of Medicine","award":["yskf2-23-1107-3"],"award-info":[{"award-number":["yskf2-23-1107-3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Maternal weight management during pregnancy is important for infant health, given the potential impact of overweight on offspring neurodevelopment. This study aimed to examine the association between maternal pre-pregnancy body mass index (BMI) and infant motor development delay during the first year of life.<\/jats:p>\n                  <jats:p>This prospective cohort study included 227 mother\u2013child pairs. Maternal pre-pregnancy BMI, calculated as weight (kg)\/height (m)2, was analyzed as both a continuous and a categorical variable (underweight: &lt;18.5\u202fkg\/m2; normal: 18.5\u201323.9\u202fkg\/m2; overweight\/obese: \u226524\u202fkg\/m2). Infant motor development was assessed using the Alberta Infant Motor Scale (AIMS) at 3, 6, 9, and 12 months of age. Group differences were tested with standard univariate methods. We used linear and non-linear regression models to explore potential associations between pre-pregnancy BMI and AIMS total scores.<\/jats:p>\n                  <jats:p>This study found that 26% of the mothers had pre-pregnancy overweight\/obesity. Among the infants, 115 were boys, and 112 were girls, and the mean birth weight was 2.61\u2009\u00b1\u20090.50\u2009kg. After full adjustment, higher pre-pregnancy BMI was inversely associated with 12-month AIMS total scores (\u03b2\u2009=\u2009\u2212\u20090.37, 95% CI: \u22120.69 to \u22120.05). A significant J-shaped non-linear association was identified, with BMI \u226525\u2009kg\/m2 marking a threshold for elevated motor delay risk. For BMI \u226525\u2009kg\/m2, each 1-kg\/m2 increase corresponded to a 1.22-point reduction in AIMS total scores and a 96% higher odds of atypical motor development (OR\u2009=\u20091.96, 95% CI: 1.28\u20133.00).<\/jats:p>\n                  <jats:p>Elevated maternal pre-pregnancy BMI is associated with increasing motor delay during infancy, with a non-linear threshold near BMI \u226525\u2009kg\/m2. Preconception weight management is vital for optimizing early neurodevelopment.<\/jats:p>","DOI":"10.1055\/a-2870-6657","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T23:14:27Z","timestamp":1781133267000},"source":"Crossref","is-referenced-by-count":0,"title":["Association between Maternal Pre-Pregnancy BMI and Early Motor Development in Chinese Infants: A Prospective Birth Cohort Study"],"prefix":"10.1055","author":[{"given":"Qimeng","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China"},{"name":"Children's Rehabilitation Innovation and Transformation Research Center of Yuanshen Rehabilitation Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juping","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China"},{"name":"Children's Rehabilitation Innovation and Transformation Research Center of Yuanshen Rehabilitation Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengquan","family":"Chen","sequence":"additional","affiliation":[{"name":"Mental Health Center Affiliated to Shanghai University of Medicine & Health Sciences, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengdie","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfang","family":"Huang","sequence":"additional","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4349-5088","authenticated-orcid":false,"given":"Qing","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China"},{"name":"Children's Rehabilitation Innovation and Transformation Research Center of Yuanshen Rehabilitation Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"issue":"11","key":"ref2","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.1111\/dom.15238","article-title":"Prevalence of obesity and associated complications in China: A cross-sectional, real-world study in 15.8 million adults","volume":"25","author":"K Chen","year":"2023","journal-title":"Diabetes Obes Metab"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1056\/NEJMra1801040","article-title":"Obesity in pregnancy","volume":"387","author":"A A Creanga","year":"2022","journal-title":"N Engl J Med"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1159\/000350706","article-title":"The molecular mechanisms of offspring effects from obese pregnancy","volume":"6","author":"D Dowling","year":"2013","journal-title":"Obes 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concurrent validity of a Chinese version of the Alberta Infant Motor Scale administered to high-risk infants in China","volume":"2018","author":"H Wang","year":"2018","journal-title":"BioMed Res Int"},{"issue":"01","key":"ref18","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1186\/s12887-023-04402-6","article-title":"Concurrent and predictive validity of the Alberta Infant Motor Scale and the Peabody Developmental Motor Scales-2 administered to infants born preterm in Norway","volume":"23","author":"T Ustad","year":"2023","journal-title":"BMC Pediatr"},{"issue":"04","key":"ref19","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/obr.12643","article-title":"Maternal pre-pregnancy obesity and child neurodevelopmental outcomes: A meta-analysis","volume":"19","author":"C E Sanchez","year":"2018","journal-title":"Obes Rev"},{"issue":"05","key":"ref20","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1038\/s41390-024-03620-7","article-title":"Prenatal 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