{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T23:03:44Z","timestamp":1780355024923,"version":"3.54.1"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Newborns are highly vulnerable to meningitis due to an immature blood-brain\n                        barrier. In cases of suspected clinical sepsis, empirical antibiotics are\n                        typically initiated after obtaining appropriate cultures when clinically\n                        indicated. This study aimed to evaluate the clinical utility of syndromic\n                        meningitis\/encephalitis (sME) molecular panel testing in neonates with\n                        suspected sepsis, with a focus on its impact on clinical management and\n                        outcomes under selective versus routine testing strategies.<\/jats:p>\n                  <jats:p>Data of 58 neonates hospitalized between January 2019 and August 2023 who\n                        underwent sME panel testing on cerebrospinal fluid (CSF) samples were\n                        retrospectively analyzed. The test was performed selectively in Period 1\n                        (January 2019\u2013October 2022) and routinely in Period 2 (October 2022\u2013August\n                        2023). Patient findings were compared between periods in terms of diagnostic\n                        stewardship principles.<\/jats:p>\n                  <jats:p>The mean gestational age and birth weight were 36\u00b14 weeks and 2,334\u00b1941 g,\n                        respectively. In Period 1, herpes simplex virus (HSV) was detected in two\n                        (7.4%) patients, and antiviral therapy was started. In Period 2, one case\n                        each of human herpesvirus 6 (HHV-6) and enterovirus was identified. The\n                        length of antibiotic treatment and hospital stay was similar between sME\n                        panel-positive (n=4) and -negative (n=54) patients during the study period\n                        (p=0.241 and p=0.890, respectively). No positive CSF cultures were found in\n                        any of the 58 neonates.<\/jats:p>\n                  <jats:p>In neonates with suspected sepsis, sME panels may assist early identification\n                        of high-risk viral agents like HSV. However, given their cost and limited\n                        treatment impact without clear clinical indications, selective use based on\n                        clinical suspicion may offer a more appropriate and cost-effective\n                        approach.<\/jats:p>","DOI":"10.1055\/a-2874-4490","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T22:42:07Z","timestamp":1780353727000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinical Utility of the Syndromic Meningitis\/Encephalitis Molecular\n                    Panel in Neonates with Suspected Sepsis"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7482-8175","authenticated-orcid":false,"given":"Ferhan","family":"Demirtas","sequence":"additional","affiliation":[{"name":"Ankara University Faculty of Medicine, Ankara, Turkey","place":["Ankara"],"department":["Department of Pediatrics, Division of Neonatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130peksu","family":"Yaz\u0131r","sequence":"additional","affiliation":[{"name":"Ankara University School of Medicine, Ankara, Turkey","place":["Ankara"],"department":["Department of Pediatrics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4580-3128","authenticated-orcid":false,"given":"Yasemin Ezgi","family":"Kostekci","sequence":"additional","affiliation":[{"name":"Ankara University Faculty of Medicine, Ankara, Turkey","place":["Ankara"],"department":["Department of Pediatrics, Division of Neonatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duygu","family":"\u00d6cal","sequence":"additional","affiliation":[{"name":"Ankara University School of Medicine, Ankara, Turkey","place":["Ankara"],"department":["Department of Microbiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emel","family":"Okulu","sequence":"additional","affiliation":[{"name":"Ankara University Faculty of Medicine, Ankara, Turkey","place":["Ankara"],"department":["Department of Pediatrics, Division of Neonatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halil","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Ankara University Faculty of Medicine, Ankara, Turkey","place":["Ankara"],"department":["Department of Pediatrics, Division of Pediatric Infectious\n                    Disease"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6mer","family":"Erdeve","sequence":"additional","affiliation":[{"name":"Ankara University Faculty of Medicine, Ankara, Turkey","place":["Ankara"],"department":["Department of Pediatrics, Division of Neonatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ergin","family":"\u00c7ift\u00e7i","sequence":"additional","affiliation":[{"name":"Ankara University Faculty of Medicine, Ankara, Turkey","place":["Ankara"],"department":["Department of Pediatrics, Division of Pediatric Infectious\n                    Disease"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep Ceren","family":"Karahan","sequence":"additional","affiliation":[{"name":"Ankara University School of Medicine, Ankara, Turkey","place":["Ankara"],"department":["Department of Microbiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Begum","family":"Atasay","sequence":"additional","affiliation":[{"name":"Ankara University Faculty of Medicine, Ankara, Turkey","place":["Ankara"],"department":["Department of Pediatrics, Division of Neonatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saadet","family":"Arsan","sequence":"additional","affiliation":[{"name":"Ankara University Faculty of Medicine, Ankara, Turkey","place":["Ankara"],"department":["Department of Pediatrics, Division of Neonatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"109319","DOI":"10.1016\/j.celrep.2021.109319","article-title":"Neonatal susceptibility to meningitis results from the immaturity of epithelial\n                    barriers and gut microbiota","volume":"35","author":"L Travier","year":"2021","journal-title":"Cell Rep"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1056\/NEJMoa1005384","article-title":"Bacterial meningitis in the United States, 1998\u20132007","volume":"364","author":"M C Thigpen","year":"2011","journal-title":"N Engl J 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North Am"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s15010-018-1212-7","article-title":"Clinical benefits of introducing real-time multiplex PCR for cerebrospinal fluid\n                    as routine diagnostic at a tertiary care pediatric center","volume":"47","author":"A Eichinger","year":"2019","journal-title":"Infection"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e01940","DOI":"10.1128\/jcm.01940-01917","article-title":"One year in the life of a rapid syndromic panel for meningitis\/encephalitis: a\n                    pediatric tertiary care facility's experience","volume":"56","author":"S N Naccache","year":"2018","journal-title":"J Clin Microbiol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1053\/j.semperi.2007.01.003","article-title":"Herpes simplex virus infections of the newborn","volume":"31","author":"D W Kimberlin","year":"2007","journal-title":"Semin Perinatol"},{"key":"ref12","first-page":"143","article-title":"Neonatal herpes simplex virus infection among Medicaid-enrolled children:\n                    2009\u20132015","author":"S Mahant","year":"2019","journal-title":"Pediatrics"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"e01137","DOI":"10.1128\/jvi.01137-01117","article-title":"Inherited chromosomally integrated human herpesvirus 6 genomes are ancient,\n                    intact, and potentially able to reactivate from telomeres","volume":"91","author":"E Zhang","year":"2017","journal-title":"J Virol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jpeds.2020.03.023","article-title":"Human herpesvirus 6 detection during the evaluation of sepsis in infants using\n                    the FilmArray meningitis\/encephalitis panel","volume":"223","author":"K L Dantuluri","year":"2020","journal-title":"J Pediatr"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1542\/peds.2007-2838","article-title":"Chromosomal integration of human herpesvirus 6 is the major mode of congenital\n                    human herpesvirus 6 infection","volume":"122","author":"C B Hall","year":"2008","journal-title":"Pediatrics"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1186\/1471-2334-13-487","article-title":"Improving the diagnosis of meningitis due to enterovirus and herpes simplex\n                    virus I and II in a tertiary care hospital","volume":"13","author":"E Casaroto","year":"2013","journal-title":"BMC Infect Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12887-020-1944-2","article-title":"Comparison of antibiotic and acyclovir usage before and after the implementation\n                    of an on-site FilmArray meningitis\/encephalitis panel in an academic tertiary\n                    pediatric hospital: a retrospective observational study","volume":"20","author":"A Hagen","year":"2020","journal-title":"BMC Pediatr"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1186\/s12879-025-10732-w","article-title":"Clinical utility of the FilmArray\u00ae meningitis\/encephalitis panel in children\n                    with suspected central nervous system infection in a low-resource setting \u2013 a\n                    prospective study in Southwestern Uganda","volume":"25","author":"R Rasti","year":"2025","journal-title":"BMC Infect Dis"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1542\/hpeds.2019-0064","article-title":"Association of the FilmArray Meningitis\/Encephalitis Panel with clinical\n                    management","volume":"9","author":"A M Nabower","year":"2019","journal-title":"Hosp Pediatr"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1093\/milmed\/usx025","article-title":"A tertiary care center\u2019s experience with novel molecular meningitis\/encephalitis\n                    diagnostics and implementation with antimicrobial stewardship","volume":"183","author":"D Chang","year":"2018","journal-title":"Mil Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.17161\/kjm.v12i1.11695","article-title":"Contribution of the BioFire\u00ae FilmArray\u00ae meningitis\/encephalitis\n                    panel: assessing antimicrobial duration and length of stay","volume":"12","author":"K Dack","year":"2019","journal-title":"Kans J Med"}],"container-title":["Zeitschrift f\u00fcr Geburtshilfe und 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