{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T23:29:11Z","timestamp":1786404551157,"version":"build-2736575974"},"reference-count":20,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Severe acute respiratory syndrome coronavirus-2 infection is a systemic disease\n                    associated with metabolic and hormonal disturbances, including thyroid\n                    dysfunction such as primary hypothyroidism, subacute thyroiditis, and\n                    non-thyroidal illness syndrome. This study aimed to investigate the association\n                    between severe acute respiratory syndrome coronavirus-2 infection and changes in\n                    thyroid function during hospitalization and follow-up and evaluate whether these\n                    alterations are related to disease severity. We retrospectively analyzed a\n                    random cohort of 500 patients admitted to the Medicine Department of a central\n                    hospital between March 2020 and 2022. After excluding deaths, prior thyroid\n                    disease, and cases without thyroid evaluation, 218 patients were included. Serum\n                    thyroid-stimulating hormone, free triiodothyronine and free thyroxine values\n                    were measured at admission and after hospitalization. Patients were classified\n                    as having thyrotoxicosis, hypothyroidism, isolated hypothyroxinemia,\n                    and non-thyroidal illness syndrome. Thyroid dysfunction was defined by\n                    compatible biochemical findings with serological and\/or imaging evidence of\n                    thyroid pathology and\/or the need for therapy. COVID-19 cases were grouped by\n                    severity. Non-thyroidal illness syndrome was the most frequent abnormality,\n                    followed by isolated hypothyroxinemia and primary hypothyroidism. Non-thyroidal\n                    illness syndrome was more common in severe cases of COVID-19, although no\n                    statistically significant association was found between disease severity and\n                    type of thyroid abnormality. Most reassessed patients showed normalization of\n                    thyroid function during follow-up. The small sample size may have limited\n                    statistical power. Thyroid function alterations are common in severe acute\n                    respiratory syndrome coronavirus-2 infection, transient, and more frequent in\n                    severe disease. These findings suggest an adaptive response to systemic stress\n                    and inflammation. Larger prospective studies are needed to clarify evolution and\n                    clinical impact.<\/jats:p>","DOI":"10.1055\/a-2874-9616","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T23:07:57Z","timestamp":1779404877000},"page":"318-322","source":"Crossref","is-referenced-by-count":0,"title":["Severe Acute Respiratory Syndrome Coronavirus-2 Infection and New\n                    Changes in Thyroid Function Parameters During Hospitalization and\n                    Follow-Up"],"prefix":"10.1055","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3022-6139","authenticated-orcid":false,"given":"Francisca","family":"Leit\u00e3o Henriques","sequence":"additional","affiliation":[{"name":"ULS Almada-Seixal, Portugal","place":["Almada"],"department":["Endocrinology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina","family":"Pestana Santos","sequence":"additional","affiliation":[{"name":"Internal Medicine, Portugal","place":["Almada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Qu\u00edtalo","sequence":"additional","affiliation":[{"name":"ULS Almada-Seixal, Portugal","place":["Almada"],"department":["Endocrinology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago","family":"Judas","sequence":"additional","affiliation":[{"name":"Internal Medicine, Portugal","place":["Almada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Gon\u00e7alves Ferreira","sequence":"additional","affiliation":[{"name":"ULS Almada-Seixal, Portugal","place":["Almada"],"department":["Endocrinology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique","family":"Vara Luiz","sequence":"additional","affiliation":[{"name":"ULS Almada-Seixal, Portugal","place":["Almada"],"department":["Endocrinology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Carlos","family":"Cordeiro","sequence":"additional","affiliation":[{"name":"ULS Almada-Seixal, Portugal","place":["Almada"],"department":["Endocrinology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Delerue","sequence":"additional","affiliation":[{"name":"Internal Medicine, Portugal","place":["Almada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.15605\/jafes.035.02.01","article-title":"COVID-19 and thyroid diseases: how the pandemic situation affects thyroid\n                    disease patients?","volume":"35","author":"L A Pramono","year":"2020","journal-title":"J ASEAN Fed Endocr Soc"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1007\/s40618-021-01554-z","article-title":"Thyroid and COVID-19: a review on pathophysiological, clinical and\n                    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Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2874-9616.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T22:59:49Z","timestamp":1786402789000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2874-9616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,21]]},"references-count":20,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2026,8,10]]},"published-print":{"date-parts":[[2026,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2874-9616","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,21]]}}}