{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:02:09Z","timestamp":1779840129800,"version":"3.53.1"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"abstract":"Abstract<\/jats:title>\n Rheumatological diseases may cause interstitial lung damage. This study aimed\n to investigate the association between pediatric body composition parameters\n and interstitial lung disease in patients with rheumatological\n conditions.<\/jats:p>\n In this cross-sectional study, all patients aged 8\u201318 years with\n rheumatological diseases and chronic respiratory symptoms were evaluated for\n interstitial lung disease using spirometry, thorax computed tomography, and\n carbon monoxide diffusion tests. Nutritional status and body composition\n were assessed using bioelectrical impedance analysis, body mass index, and\n fat-free mass index. Patients were categorized into three groups, group I\n (normal fat-free mass index and body mass index), group II (sarcopenia\u2014low\n fat-free mass index but normal body mass index), and group III (malnutrition\n with both low fat-free mass index and body mass index).<\/jats:p>\n A total of 26 patients were included, and the median age was 169.03 (94\u2013216)\n months. The median body mass index was 21.9 (14.4-33.8) kg\/m2.\n Sixteen (62%) patients had normal body mass index and normal fat-free mass\n index (group I), four (15%) patients had normal body mass index and low\n fat-free mass index (group II), and six (23%) patients had low body mass\n index and low fat-free mass index (group III). Among the pulmonary function\n tests, the median (interquartile range) carbon monoxide diffusion\n tests\u200b\u200b\u200b\u200b\u200b\u200b z-score was \u22122.3 (\u22124.9 to 0.06). A positive correlation\n was found between carbon monoxide diffusion tests z-scores and\n fat-free mass index (r=0.589, p=0.002). Fat-free mass index\n was significantly lower in the group with carbon monoxide diffusion tests\n z-scores of <\u22121.64.<\/jats:p>\n Nutritional status may be associated with pulmonary function test results in\n children with interstitial lung disease-related rheumatological\n diseases.<\/jats:p>","DOI":"10.1055\/a-2875-4698","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T23:03:07Z","timestamp":1779836587000},"source":"Crossref","is-referenced-by-count":0,"title":["Association of Fat-free Mass Index and Body Mass Index on Pulmonary\n Function Tests in Children with Rheumatological Disease-associated Interstitial\n Lung Disease"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2689-7904","authenticated-orcid":false,"given":"Asl\u0131 \u0130mran","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Konya City Hospital, 237, Turkey","place":["Konya"],"department":["Pediatric Pulmonology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevgi","family":"Pekcan","sequence":"additional","affiliation":[{"name":"Necmettin Erbakan University Faculty of Medicine, Konya, Turkey","place":["Meram"],"department":["Pediatric Pulmonology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tu\u011fba","family":"\u015ei\u015fmanlar Ey\u00fcbo\u011flu","sequence":"additional","affiliation":[{"name":"Gazi University Faculty of Medicine, Turkey","place":["Ankara"],"department":["Pediatric Pulmonology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00fc\u015ferref","family":"Kasap C\u00fcceo\u011flu","sequence":"additional","affiliation":[{"name":"Konya City Hospital, Konya, Turkey","place":["Konya"],"department":["Pediatric Rheumatology Diseases"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9563-0296","authenticated-orcid":false,"given":"Ayca Burcu","family":"Kahraman","sequence":"additional","affiliation":[{"name":"Konya City Hospital, Konya, Turkey","place":["Konya"],"department":["Pediatric Metabolism Disease"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zafer","family":"Ba\u011fc\u0131","sequence":"additional","affiliation":[{"name":"Konya City Hospital, Konya, Turkey","place":["Konya"],"department":["Pediatrics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malik S\u00fcleyman","family":"G\u00fczel","sequence":"additional","affiliation":[{"name":"Konya City Hospital, Konya, Turkey","place":["Konya"],"department":["Pediatrics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Ercan","sequence":"additional","affiliation":[{"name":"Necmettin Erbakan University Faculty of Medicine, Konya, Turkey","place":["Meram"],"department":["Pediatric Pulmonology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanife Tu\u011f\u00e7e","family":"\u00c7a\u011flar","sequence":"additional","affiliation":[{"name":"Necmettin Erbakan University Faculty of Medicine, Konya, Turkey","place":["Meram"],"department":["Pediatric Pulmonology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma Nur","family":"Ayman","sequence":"additional","affiliation":[{"name":"Necmettin Erbakan University Faculty of Medicine, Konya, Turkey","place":["Meram"],"department":["Pediatric Pulmonology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suat","family":"Sava\u015f","sequence":"additional","affiliation":[{"name":"Necmettin Erbakan University Faculty of Medicine, Konya, Turkey","place":["Meram"],"department":["Pediatric Pulmonology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"ref1","first-page":"295","article-title":"Childhood interstitial lung disease in Turkey: first data from the national\n registry","volume":"18","author":"H Nay\u0131r-B\u00fcy\u00fck\u015fahin","year":"2024","journal-title":"Eur J Pediatr"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1750-1172-4-26","article-title":"Incidence and classification of pediatric diffuse parenchymal lung diseases in\n Germany","volume":"4","author":"M Griese","year":"2009","journal-title":"Orphanet J Rare Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1159\/000512732","article-title":"Fat-free mass index controlled for age and Sex and malnutrition are predictors\n of survival in interstitial lung disease","volume":"100","author":"S Rinaldi","year":"2021","journal-title":"Respiration"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"200019","DOI":"10.1183\/16000617.0019-2020","article-title":"Pulmonary function testing in children\u2019s interstitial lung disease","volume":"29","author":"A M Ring","year":"2020","journal-title":"Eur Respir Rev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1080\/10255842.2021.1974848","article-title":"Effect of muscle distribution on lung function in young adults","volume":"25","author":"W Shu","year":"2022","journal-title":"Comput Methods Biomech Biomed Eng"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1093\/ajcn\/82.1.53","article-title":"Body composition and mortality in chronic obstructive pulmonary disease","volume":"82","author":"A M Schols","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e14373","DOI":"10.1097\/MD.0000000000014373","article-title":"Association of loss of muscle mass with mortality in liver cirrhosis without or\n before liver transplantation: A systematic review and meta-analysis","volume":"98","author":"K V Chang","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/resp.12941","article-title":"Fat-free mass index predicts survival in patients with idiopathic pulmonary\n fibrosis","volume":"22","author":"O Nishiyama","year":"2017","journal-title":"Respirology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2114\/jpa.22.293","article-title":"Reference norms for a fat-free mass index and fat mass index in the Japanese\n child population","volume":"22","author":"T Nakao","year":"2003","journal-title":"J Physiol Anthropol Appl Human Sci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/ncp.10251","article-title":"Association between fat-free mass and pulmonary function in patients with cystic\n fibrosis: A narrative review","volume":"34","author":"A Gomes","year":"2019","journal-title":"Nutr Clin Pract"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.clnu.2012.04.012","article-title":"Use of body mass index percentile to identify fat-free mass depletion in\n children with cystic fibrosis","volume":"31","author":"M P Engelen","year":"2012","journal-title":"Clin Nutr"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e487","DOI":"10.1542\/peds.2005-0572","article-title":"Do changes in body mass index percentile reflect changes in body composition in\n children? Data from the Fels Longitudinal Study","volume":"117","author":"E W Demerath","year":"2006","journal-title":"Pediatrics"},{"issue":"03","key":"ref13","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.ccm.2024.04.002","article-title":"Innovations in childhood interstitial and diffuse lung disease","volume":"45","author":"A Casey","year":"2024","journal-title":"Clin Chest Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2101499","DOI":"10.1183\/13993003.01499-2021","article-title":"ERS\/ATS technical standard on interpretive strategies for routine lung function\n tests","volume":"60","author":"S Stanojevic","year":"2022","journal-title":"Eur Respir J"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e7038","DOI":"10.1371\/journal.pone.0007038","article-title":"Dual energy X-Ray absorptiometry body composition reference values from\n NHANES","volume":"4","author":"T L Kelly","year":"2009","journal-title":"PLoS One"},{"key":"ref16","volume-title":"Levels and trends in child malnutrition: UNICEF\/WHO\/World Bank Group Joint Child\n Malnutrition Estimates: Key findings of the 2023 edition","author":"United Nations Children\u2019s Fund (UNICEF), World Health\n Organization (WHO), International Bank for Reconstruction and\n Development\/The World Bank","year":"2023"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3945\/ajcn.112.053611","article-title":"Fat and lean BMI reference curves in children and adolescents and their utility\n in identifying excess adiposity compared with BMI and percentage body fat","volume":"98","author":"D R Weber","year":"2013","journal-title":"Am J Clin Nutr"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1093\/ajcn\/53.5.1112","article-title":"Fat-free mass in relation to stature: Ratios of fat-free mass to height in\n children, adults, and elderly subjects","volume":"53","author":"H L Barlett","year":"1991","journal-title":"Am J Clin Nutr"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.clnu.2004.08.012","article-title":"Increased length of hospital stay in underweight and overweight patients at\n hospital admission: A controlled population study","volume":"24","author":"U G Kyle","year":"2005","journal-title":"Clin Nutr"},{"key":"ref20","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4419-6646-9","volume-title":"Survival analysis a self-learning text","author":"D G Kleinbaum","year":"2012"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s12325-022-02382-0","article-title":"Real-world clinical outcomes based on body mass index and annualized weight\n change in patients with idiopathic pulmonary fibrosis","volume":"40","author":"J S Lee","year":"2023","journal-title":"Adv Ther"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.chest.2021.11.008","article-title":"Association of BMI and change in weight with mortality in patients with fibrotic\n interstitial lung disease","volume":"161","author":"A Comes","year":"2022","journal-title":"Chest"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"200019","DOI":"10.1183\/16000617.0019-2020","article-title":"Pulmonary function testing in children\u2019s interstitial lung disease","volume":"29","author":"A M Ring","year":"2020","journal-title":"Eur Respir Rev"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1136\/thorax.58.10.885","article-title":"Altered tissue distribution in adults with cystic fibrosis","volume":"58","author":"C E Bolton","year":"2003","journal-title":"Thorax"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.clnu.2011.12.011","article-title":"Body composition: Why, when and for who?","volume":"31","author":"R Thibault","year":"2012","journal-title":"Clin Nutr"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/resp.14892","article-title":"Dynapenia and sarcopenia as risk factors for mortality in interstitial lung\n disease","volume":"30","author":"A A Ibarra-Fern\u00e1ndez","year":"2025","journal-title":"Respirology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12931-024-02705-5","article-title":"Association of musculoskeletal involvement with lung function and mortality in\n patients with idiopathic pulmonary fibrosis","volume":"25","author":"M Sridhar","year":"2024","journal-title":"Respir Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1093\/ajcn\/82.1.53","article-title":"Body composition and mortality in chronic obstructive pulmonary disease","volume":"82","author":"A M Schols","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.clnu.2023.12.017","article-title":"ESPEN-ESPGHAN-ECFS guideline on nutrition care for cystic fibrosis","volume":"43","author":"M Wilschanski","year":"2024","journal-title":"Clin Nutr"}],"container-title":["Klinische P\u00e4diatrie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2875-4698.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T23:03:15Z","timestamp":1779836595000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2875-4698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,26]]},"references-count":29,"URL":"https:\/\/doi.org\/10.1055\/a-2875-4698","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0300-8630","1439-3824"],"issn-type":[{"value":"0300-8630","type":"print"},{"value":"1439-3824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,26]]}}}