{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T22:58:52Z","timestamp":1781218732863,"version":"3.54.1"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultraschall Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To evaluate the impact of changes in legislation regarding termination of pregnancy (TOP) and new diagnostic procedures such as non-invasive prenatal testing (NIPT) on timing and diagnoses of medically indicated TOPs at a tertiary obstetric center during a 22-year period.<\/jats:p>\n                  <jats:p>This retrospective study was conducted at the Department of Obstetrics and Gynecology of a tertiary obstetric center between 2002 and 2023. Data on TOP was extracted from the electronic patient files. Cases were divided into subgroups according to legislative changes as well as groups before and after the introduction of NIPT. Descriptive statistics were computed and Mann-Whitney-U and Kruskal-Wallis tests were conducted to compare the non-normally distributed variables among subgroups.<\/jats:p>\n                  <jats:p>1726 cases of TOP were included in this study. Altogether, there was no noticeable change in diagnoses for TOP over the 22-year study period. We observed a noticeable increase in gestational age at the time of TOP which remained, however, below fetal viability. Towards the end of the study period, there was a noticeable increase in TOP requiring feticide.<\/jats:p>\n                  <jats:p>Neither changes in TOP legislation nor the introduction of NIPT resulted in a steep increase in TOP for certain diagnoses. The increase in gestational age as well as the increasing number of feticides can most likely be attributed to multiple factors beyond changes in legislation and diagnostic procedures.<\/jats:p>","DOI":"10.1055\/a-2875-5116","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T22:53:46Z","timestamp":1781218426000},"source":"Crossref","is-referenced-by-count":0,"title":["Is there a slippery slope? \u2013 Data on 22 years of medically indicated terminations of pregnancy from a tertiary obstetric center in Germany"],"prefix":"10.1055","author":[{"given":"Emilia","family":"Brinkman","sequence":"first","affiliation":[{"name":"University Hospital M\u00fcnster, Germany","place":["M\u00fcnster"],"department":["Department of Gynecology and Obstetrics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mareike","family":"M\u00f6llers","sequence":"first","affiliation":[{"name":"University Hospital M\u00fcnster, Germany","place":["M\u00fcnster"],"department":["Department of Gynecology and Obstetrics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Willy","sequence":"additional","affiliation":[{"name":"University Hospital M\u00fcnster, Germany","place":["M\u00fcnster"],"department":["Department of Gynecology and Obstetrics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen Marie","family":"Oberste","sequence":"additional","affiliation":[{"name":"University Hospital M\u00fcnster, Germany","place":["M\u00fcnster"],"department":["Department of Gynecology and Obstetrics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Schmitz","sequence":"additional","affiliation":[{"name":"Kaiserswerther Diakonic Association, Germany","place":["D\u00fcsseldorf"],"department":["Gynecology and Obstetrics, Florence-Nightingale-Hospital"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Steinhard","sequence":"additional","affiliation":[{"name":"Heart and Diabetes Center NRW Bad Oeynhausen, Germany","place":["Bad Oeynhausen"],"department":["Fetal Cardiology"]},{"name":"Center for Prenatal Diagnosis and Medical Genetics, Germany","place":["Munster"],"department":["Prenatal Diagnosis and Medical Genetics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz Fabian","family":"Danzer","sequence":"additional","affiliation":[{"name":"University of M\u00fcnster, Germany","place":["M\u00fcnster"],"department":["Institute of Biostatistics and Clinical Research"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8298-6966","authenticated-orcid":false,"given":"Kathrin","family":"Oelmeier","sequence":"additional","affiliation":[{"name":"University Hospital M\u00fcnster, Germany","place":["M\u00fcnster"],"department":["Department of Gynecology and Obstetrics"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"issue":"02","key":"ref2","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1038\/s41431-024-01612-z","article-title":"Negotiating severity behind the scenes: prenatal testing in Germany","volume":"33","author":"T Nov-Klaiman","year":"2025","journal-title":"Eur J Hum Genet"},{"issue":"05","key":"ref4","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1111\/ajo.12817","article-title":"Abortion law reform: Why ethical intractability and maternal morbidity are grounds for decriminalisation","volume":"58","author":"A McGee","year":"2018","journal-title":"Aust NZ J Obst Gynaeco"},{"issue":"03","key":"ref6","doi-asserted-by":"publisher","first-page":"101441","DOI":"10.1016\/j.siny.2023.101441","article-title":"Counseling for the option of termination of pregnancy for severe fetal anomalies in light of the recent Supreme Court ruling to remove the constitutional right to an abortion","volume":"28","author":"A Gr\u00fcnebaum","year":"2023","journal-title":"Seminars in Fetal and Neonatal Medicine"},{"issue":"06","key":"ref7","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/s41431-021-00970-2","article-title":"The ethical landscape(s) of non-invasive prenatal testing in England, France and Germany: findings from a comparative literature review","volume":"30","author":"A Perrot","year":"2022","journal-title":"Eur J Hum Genet"},{"issue":"06","key":"ref8","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1111\/bioe.12880","article-title":"Avoiding \u201cselection\u201d? \u2013 References to history in current German policy debates about non-invasive prenatal testing","volume":"35","author":"H Foth","year":"2021","journal-title":"Bioethics"},{"issue":"03","key":"ref9","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1080\/14636778.2018.1495555","article-title":"Realizing responsibility. 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