{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:47:25Z","timestamp":1782258445633,"version":"3.54.5"},"reference-count":19,"publisher":"Georg Thieme Verlag KG","funder":[{"DOI":"10.13039\/501100005668","name":"Funda\u00e7\u00e3o de Apoio \u00e0 Pesquisa do Distrito\n      Federal","doi-asserted-by":"crossref","award":["Public Call 05\/2024\u2014Spontaneous Demand"],"award-info":[{"award-number":["Public Call 05\/2024\u2014Spontaneous Demand"]}],"id":[{"id":"10.13039\/501100005668","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Sports Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Circulating irisin, a myokine linked to exercise-induced metabolic adaptation, may respond to\n     exercise intensity and serve as a marker of training status. This study assessed\n     intensity-dependent acute irisin responses in master athletes and recreationally trained men,\n     baseline irisin associations with maximal oxygen uptake and body fat, and fibronectin type III\n     domain\u2013containing protein 5-related pathways using bioinformatics. Master endurance athletes\n      (n=11; 49.9\u00b15.8 y) and recreationally trained men (n=10; 49.9\u00b17.2 y) completed\n     two running sessions (moderate and severe), and plasma irisin was measured at rest and 15- and\n     120-minutes post-exercise. Exercise intensity significantly modulated acute irisin responses\n     (time\u00d7intensity, p=0.006), with greater and earlier increases after severe exercise.\n     Master endurance athletes exhibited consistently higher irisin than recreationally trained men\n      (p&lt;0.001), with intensity effects in both groups; baseline irisin was inversely\n     associated with body fat (p=0.018) and positively with maximal oxygen uptake\n     (p&lt;0.001). Complementary RNA-seq analyses showed an age-related decline in skeletal\n     muscle fibronectin type III domain\u2013containing protein 5 expression, preserved by long-term\n     endurance training via upregulated mitochondrial and energy metabolism pathways. Together,\n     these findings indicate that exercise intensity and lifelong training modulate irisin\n     regulation, supporting its use as a biomarker of aerobic fitness, metabolic adaptation, and\n     healthy aging.<\/jats:p>","DOI":"10.1055\/a-2876-1454","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:05:03Z","timestamp":1782255903000},"source":"Crossref","is-referenced-by-count":0,"title":["Exercise Intensity Effects on Irisin in Master Athletes and Links With Maximal\n     Oxygen Uptake and Body Fat"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9970-5868","authenticated-orcid":false,"given":"Patr\u00edcio Lopes de Ara\u00fajo","family":"Leite","sequence":"additional","affiliation":[{"name":"Catholic University of Brasilia (UCB) Taguatinga, Brazil","department":["Graduate Program in Physical Activity, Health, and Human Performance"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0743-1746","authenticated-orcid":false,"given":"Larissa Alves","family":"Maciel","sequence":"additional","affiliation":[{"name":"Catholic University of Brasilia (UCB) Taguatinga, Brazil","department":["Graduate Program in Physical Activity, Health, and Human Performance"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita Cristine Barboza","family":"Patricio","sequence":"additional","affiliation":[{"name":"University of Bras\u00edlia (UNB), Brazil","place":["Ceil\u00e2ndia"],"department":["Graduate Program in Physical Therapy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7728-0798","authenticated-orcid":false,"given":"Walliyson Sousa","family":"Lima","sequence":"additional","affiliation":[{"name":"Catholic University of Brasilia (UCB) Taguatinga, Brazil","department":["Graduate Program in Physical Activity, Health, and Human Performance"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caio Victor de Sousa","family":"Silva","sequence":"additional","affiliation":[{"name":"Loyola Marymount University, USA","place":["Los Angeles"],"department":["Department of Health and Human Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9057-4096","authenticated-orcid":false,"given":"Samuel Silva","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Catholic University of Brasilia (UCB) Taguatinga, Brazil","department":["Graduate Program in Physical Activity, Health, and Human Performance"]},{"name":"Catholic University of Bras\u00edlia, Brazil","place":["Taguatinga"],"department":["Graduate Program in Genomic Sciences and Biotechnology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo Vieira de Sousa","family":"Neto","sequence":"additional","affiliation":[{"name":"School of Physical Education and Sport of Ribeir\u00e3o Preto, University of S\u00e3o Paulo\n     (USP), S\u00e3o Paulo, Brazil","place":["Ribeir\u00e3o Preto"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0418-0945","authenticated-orcid":false,"given":"Thiago dos Santos","family":"Rosa","sequence":"additional","affiliation":[{"name":"Catholic University of Brasilia (UCB) Taguatinga, Brazil","department":["Graduate Program in Physical Activity, Health, and Human Performance"]},{"name":"State University of Northern Paran\u00e1 (UENP), Brazil","place":["Jacarezinho"],"department":["Department of Physical Education"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela Viana","family":"Ramos","sequence":"additional","affiliation":[{"name":"Catholic University of Brasilia (UCB) Taguatinga, Brazil","department":["Graduate Program in Physical Activity, Health, and Human Performance"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Campbell","sequence":"additional","affiliation":[{"name":"Catholic University of Brasilia (UCB) Taguatinga, Brazil","department":["Graduate Program in Physical Activity, Health, and Human Performance"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2378-4026","authenticated-orcid":false,"given":"Herbert Gustavo","family":"Simoes","sequence":"additional","affiliation":[{"name":"Catholic University of Brasilia (UCB) Taguatinga, Brazil","department":["Graduate Program in Physical Activity, Health, and Human Performance"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nature10777","article-title":"A PGC1-\u03b1-dependent myokine that drives brown-fat-like development of white fat and\n     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Mckendry","year":"2018","journal-title":"Ageing Res Rev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1519\/JSC.0000000000002932","article-title":"Influence of body fat on oxidative stress and telomere length of master athletes","volume":"35","author":"S S Aguiar","year":"2021","journal-title":"J Strength Cond Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1055\/s-0043-120345","article-title":"Longer telomere length in elite master sprinters: Relationship to performance and body\n     composition","volume":"38","author":"H G Simoes","year":"2017","journal-title":"Int J Sports Med"},{"key":"ref8","first-page":"709","article-title":"The relationship between power and the time to achieve V\u0307\u200bO2max","volume":"34","author":"D W Hill","year":"2002","journal-title":"Med Sci Sports Exerc"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1079\/BJN19780152","article-title":"Generalized equations for 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de Medicina do Esporte"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1249\/01.MSS.0000142310.97274.94","article-title":"Validation of the Adult OMNI Scale of perceived exertion for walking\/running exercise","volume":"36","author":"A C Utter","year":"2004","journal-title":"Med Sci Sports Exerc"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"5393","DOI":"10.1113\/jphysiol.2013.263707","article-title":"Are skeletal muscle FNDC5 gene expression and irisin release regulated by exercise and\n     related to health?","volume":"591","author":"S Pekkala","year":"2013","journal-title":"J Physiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1620\/tjem.233.135","article-title":"High-intensity exercise causes greater irisin response compared with low-intensity exercise\n     under similar energy consumption","volume":"233","author":"Y Tsuchiya","year":"2014","journal-title":"Tohoku J Exp Med"},{"key":"ref17","doi-asserted-by":"crossref","DOI":"10.4324\/9780203771587","volume-title":"Statistical power analysis for the behavioral sciences","author":"J Cohen","year":"2013"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"113472","DOI":"10.1016\/j.bbr.2021.113472","article-title":"Acute effects of high-intensity interval training and moderate-intensity continuous exercise\n     on BDNF and irisin levels and neurocognitive performance in late middle-aged and older\n     adults","volume":"413","author":"C L Tsai","year":"2021","journal-title":"Behav Brain Res"},{"key":"ref19","first-page":"99","article-title":"Exercise-induced irisin secretion is independent of age or fitness level and increased\n     irisin may directly modulate muscle metabolism through AMPK activation","author":"J Y Huh","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"857270","DOI":"10.1155\/2014\/857270","article-title":"Association of irisin with fat mass, resting energy expenditure, and daily activity in\n     conditions of extreme body mass index","volume":"2014","author":"M Pardo","year":"2014","journal-title":"Int J Endocrinol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.niox.2020.05.004","article-title":"Sprint and endurance training in relation to redox balance, inflammatory status and\n     biomarkers of aging in master athletes","volume":"102","author":"T S Rosa","year":"2020","journal-title":"Nitric Oxide"}],"container-title":["International Journal of Sports Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2876-1454.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:05:05Z","timestamp":1782255905000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2876-1454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,23]]},"references-count":19,"URL":"https:\/\/doi.org\/10.1055\/a-2876-1454","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0172-4622","1439-3964"],"issn-type":[{"value":"0172-4622","type":"print"},{"value":"1439-3964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,23]]}}}