{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T23:26:54Z","timestamp":1786663614280,"version":"build-2736575974"},"reference-count":138,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Der neonatale Schlaganfall stellt eine seltene, aber klinisch bedeutsame\n                        neurologische Erkrankung mit hoher Morbidit\u00e4t und potenziell schwerwiegenden\n                        Langzeitfolgen dar. Trotz zunehmender diagnostischer M\u00f6glichkeiten bestehen\n                        Unsicherheiten hinsichtlich Diagnostik, Therapie und Nachsorge. Ziel dieser\n                        S2k-Leitlinie ist die evidenz- und konsensbasierte Standardisierung der\n                        Versorgung von Neugeborenen mit arteriell isch\u00e4mischem Schlaganfall,\n                        h\u00e4morrhagischem Schlaganfall und cerebraler Sinusvenenthrombose (CSVT).<\/jats:p>\n                  <jats:p>Die Leitlinie wurde im Rahmen eines strukturierten S2k-Konsensusverfahrens unter\n                        Beteiligung multidisziplin\u00e4rer Fachgesellschaften und Experten erstellt.\n                        Grundlage bildeten die systematische Auswertung der verf\u00fcgbaren Literatur sowie\n                        ein formalisierter Konsensprozess zur Erarbeitung diagnostischer und\n                        therapeutischer Empfehlungen.<\/jats:p>\n                  <jats:p>Die Leitlinie definiert den neonatalen Schlaganfall als akut auftretende\n                        neurologische Symptomatik innerhalb der ersten 28 Lebenstage mit MRT-gesichertem\n                        zerebrovaskul\u00e4rem Ereignis. Aufgrund der h\u00e4ufig unspezifischen klinischen\n                        Pr\u00e4sentation, insbesondere durch Krampfanf\u00e4lle, Apnoen oder Vigilanzst\u00f6rungen,\n                        wird eine rasche Diagnostik empfohlen. Als prim\u00e4re Bildgebung soll eine\n                        transfontanell\u00e4re Sonografie inklusive Doppleruntersuchung erfolgen, gefolgt von\n                        einer Magnetresonanztomografie mit Diffusions- und Gef\u00e4\u00dfdarstellung als\n                        diagnostischem Goldstandard. Eine Computertomografie wird aufgrund der\n                        Strahlenbelastung und geringen Sensitivit\u00e4t nicht empfohlen. Neugeborene mit\n                        Verdacht auf Schlaganfall oder Krampfanf\u00e4lle sollen kontinuierlich mittels\n                        bihemisph\u00e4rischem amplitudenintegriertem EEG \u00fcberwacht werden. Ein\n                        routinem\u00e4\u00dfiges Screening auf thrombophile Gerinnungsst\u00f6rungen wird bei arteriell\n                        isch\u00e4mischem Schlaganfall nicht empfohlen. Therapeutisch stehen supportive\n                        Ma\u00dfnahmen zur Sicherstellung von Normoxie, Normokapnie, Normothermie und\n                        normoglyk\u00e4mischen Stoffwechselbedingungen im Vordergrund. F\u00fcr die neonatale CSVT\n                        wird bei fehlenden Kontraindikationen eine akute und gegebenenfalls\n                        l\u00e4ngerfristige Antikoagulation empfohlen. Eine routinem\u00e4\u00dfige antithrombotische\n                        Therapie nach arteriell isch\u00e4mischem Schlaganfall wird aufgrund der niedrigen\n                        Rezidivrate nicht empfohlen.<\/jats:p>\n                  <jats:p>Die S2k-Leitlinie bietet erstmals umfassende Empfehlungen zur Diagnostik,\n                        Therapie und Langzeitbetreuung von Neugeborenen mit Schlaganfall und CSVT. Die\n                        fr\u00fchzeitige Identifikation betroffener Kinder, der gezielte Einsatz moderner\n                        Bildgebung sowie eine strukturierte interdisziplin\u00e4re Nachsorge sind\n                        entscheidend, um neurologische Folgesch\u00e4den zu minimieren und die langfristige\n                        Entwicklung zu verbessern.<\/jats:p>","DOI":"10.1055\/a-2876-5739","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T23:11:52Z","timestamp":1782169912000},"page":"276-290","source":"Crossref","is-referenced-by-count":0,"title":["Schlaganfall und Sinus-Venen-Thrombose des Neugeborenen\n                    (S2k-Leitlinie, AWMF-Register-Nr. 024-024, Version 1.0)"],"prefix":"10.1055","volume":"230","author":[{"given":"Mark","family":"Dzietko","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum D\u00fcsseldorf","department":["Klinik f\u00fcr Allgemeinp\u00e4diatrie, Neonatologie und\n                    Kinderkardiologie"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Klebermass-Schrehof","sequence":"additional","affiliation":[{"name":"Medizinische Universit\u00e4t Wien","department":["Klinische Abteilung f\u00fcr Neonatologie, P\u00e4d. Intensivmedizin und\n                    Neurop\u00e4diatrie Universit\u00e4tsklinik f\u00fcr Kinder- und Jugendheilkunde"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Hahn","sequence":"additional","affiliation":[{"name":"Universit\u00e4ts-Kinderspital beider Basel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Joachim","family":"Mentzel","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Jena","department":["Kinderradiologie Institut f\u00fcr Diagnostische und Interventionelle\n                    Radiologie"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Gerstl","sequence":"additional","affiliation":[{"name":"Dr. von Haunerschen Kinderspital, Ludwig-Maximilians-Universit\u00e4t\n                    M\u00fcnchen","department":["Klinik f\u00fcr Kinderneurologie"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr Sherif","family":"Hamza","sequence":"additional","affiliation":[{"name":"Kantonsspital Baden\n                    AG, Aargau, Switzerland","place":["Baden"],"department":["Klinik f\u00fcr Geburtshilfe und\n                Pr\u00e4natalmedizin"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Holzhauer","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","department":["Klinik f\u00fcr P\u00e4diatrie mit Schwerpunkt Onkologie und\n                    H\u00e4matologie"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Straeter","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum M\u00fcnster, Deutschland","place":["M\u00fcnster"],"department":["P\u00e4diatrische H\u00e4matologie und Onkologie, Klinik f\u00fcr Kinder- und\n                    Jugendmedizin"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Gehlken","sequence":"additional","affiliation":[{"name":"SCHAKI e.V."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1542\/peds.2007-0336","article-title":"the NICHD-NINDS Perinatal Stroke Workshop Participants (2007) Perinatal\n                    haemorrhagic stroke: summary of a workshop sponsored by NICHD and NINDS on\n                    classification, challenges and opportunities","volume":"120","author":"TN K Raju","year":"2007","journal-title":"Pediatrics"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.pediatrneurol.2003.08.004","article-title":"Fetal stroke","volume":"30","author":"K Ozduman","year":"2004","journal-title":"Pediatr 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