{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T23:58:53Z","timestamp":1780963133984,"version":"3.54.1"},"reference-count":86,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Amniotic fluid embolism (AFE) and placental abruption represent two of the most catastrophic obstetric emergencies, sharing a common pathway of severe coagulopathy while differing fundamentally in their underlying pathophysiology. AFE is characterized by sudden cardiovascular collapse, respiratory distress, and disseminated intravascular coagulation (DIC), likely triggered by an anaphylactoid-like reaction to fetal antigens entering maternal circulation. The condition manifests with both consumptive coagulopathy and hyperfibrinolysis, with platelet counts frequently falling below 50,000\/\u03bcL and precipitous drops in fibrinogen levels. Management requires immediate advanced cardiac life support and aggressive hemodynamic support, mechanical ventilation, and massive transfusion protocols guided by viscoelastic testing. Emerging therapies include extracorporeal membrane oxygenation for refractory cardiopulmonary collapse and recombinant factor VIIa for intractable hemorrhage. Placental abruption results from premature placental separation and presents vaginal bleeding, abdominal pain, and fetal compromise. The condition arises from chronic uteroplacental ischemia and decidual arteriopathy, with retroplacental hematomas serving as massive sources of tissue factors that trigger the coagulation cascade. Abruption-related DIC primarily manifests consumption coagulopathy. Unlike AFE, urgent delivery of the fetus and placenta can eliminate the source of thromboplastic material, often resolving the coagulopathy. Both conditions demand, among others, institutional preparedness with established massive transfusion protocols and multidisciplinary teams trained in obstetric critical care. While advances in viscoelastic testing, targeted factor concentrates, and life support technologies have improved outcomes, AFE and placental abruption continue to challenge even experienced obstetric teams.<\/jats:p>","DOI":"10.1055\/a-2877-3436","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T23:08:55Z","timestamp":1780960135000},"source":"Crossref","is-referenced-by-count":0,"title":["Peripartum Vascular Calamities: Placental Abruption and Amniotic Fluid Emboli"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9925-3847","authenticated-orcid":false,"given":"Amir","family":"Wolfovitz","sequence":"additional","affiliation":[{"name":"Rambam Health Care Campus, Israel","place":["Haifa"],"department":["Department of Obstetrics and Gynecology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Brenner","sequence":"additional","affiliation":[{"name":"Rambam Health Care Campus, Israel","place":["Haifa"],"department":["Department of Haematology and Bone Marrow Transplantation"]},{"name":"Technion Israel Institute of Technology, Israel","place":["Haifa"],"department":["Ruth and Bruce Rappaport Faculty of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ido","family":"Solt","sequence":"additional","affiliation":[{"name":"Rambam Health Care Campus, Israel","place":["Haifa"],"department":["Department of Obstetrics and Gynecology"]},{"name":"Technion Israel Institute of Technology, Israel","place":["Haifa"],"department":["Ruth and Bruce Rappaport Faculty of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"ref1","volume-title":"Amniotic Fluid Embolism","author":"A Haftel","year":"2025"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"130","DOI":"10.4103\/JOACC.JOACC_12_23","article-title":"Amniotic fluid embolism: a 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