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Neuropathologisch zeigt sich eine Ablagerung\n                    fehlgefalteten \u03b1-Synukleins in Oligodendrozyten, was zu einer multisystemischen\n                    Neurodegeneration f\u00fchrt. Klinisch zeigen sich eine rasche Progression,\n                    eingeschr\u00e4nkte Levodopa-Responsivit\u00e4t und fr\u00fche autonome St\u00f6rungen. Die Diagnose\n                    basiert auf klinischen Kriterien der Movement Disorder Society und\n                    charakteristischen MRT-Befunden, kann jedoch nur postmortal histopathologisch\n                    gesichert werden. Eine krankheitsmodifizierende Therapie existiert derzeit\n                    nicht, die Behandlung erfolgt symptomorientiert und multidisziplin\u00e4r. Zentrale\n                    Forschungsans\u00e4tze zielen auf die Entwicklung sensitiver Biomarker, die\n                    Fr\u00fcherkennung prodromaler Stadien und therapeutische Strategien zur Hemmung von\n                    \u03b1-Synuklein-Aggregation und Neuroinflammation.<\/jats:p>","DOI":"10.1055\/a-2877-5054","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T22:53:32Z","timestamp":1786056812000},"page":"377-388","source":"Crossref","is-referenced-by-count":1,"title":["Multisystematrophie"],"prefix":"10.1055","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0270-0029","authenticated-orcid":false,"given":"Ida","family":"Wilkens","sequence":"additional","affiliation":[{"name":"LMU Klinikum, Bayern, Germany","place":["M\u00fcnchen"],"department":["Neurologische Klinik und 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