{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T22:59:36Z","timestamp":1781045976630,"version":"3.54.1"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fortschr Neurol Psychiatr"],"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Drei Jahrzehnte Fr\u00fcherkennungs- und -interventionsforschung zu Psychosen haben\n                    spezifische Risikokriterien hervorgebracht, die bereits in einem ersten Schritt\n                    eine durchschnittlich 300-fache Risikoerh\u00f6hung anzeigen und mit der Kombination\n                    von \u201eultra-high risk\u201c\u2013 und Basissymptom-Kriterien eine erste\n                    Risikostratifizierung erlauben. F\u00fcr eine weitere, personalisierte\n                    Risikoevaluation wurden bereits vielf\u00e4ltige Modelle vorgeschlagen, von denen\n                    jedoch die wenigsten extern validiert wurden. Hinsichtlich der\n                    Psychose-pr\u00e4ventiven Interventionen zeigen sich\n                    kognitiv-verhaltenstherapeutische Ans\u00e4tze \u00fcberlegen, wobei neuere Studien eine\n                    geringe Wirksamkeit zeigten, weshalb modulare, gestufte Verfahren und\n                    alternative Substanzen aktuell erforscht werden. Vor dem Hintergrund des\n                    klinischen Psychoserisikos als eigenst\u00e4ndiges Syndrom r\u00fccken zudem neben der\n                    Psychosemanifestation weitere Ausg\u00e4nge, etwa Funktionsniveau oder Remission, in\n                    den Fokus.<\/jats:p>","DOI":"10.1055\/a-2883-4988","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T22:42:48Z","timestamp":1781044968000},"source":"Crossref","is-referenced-by-count":0,"title":["Die j\u00fcngsten Entwicklungen in der Fr\u00fcherkennung und Fr\u00fchbehandlung\n                    von klinischen Hochrisikostadien von Psychosen"],"prefix":"10.1055","author":[{"given":"Anastasia","family":"Theodoridou","sequence":"additional","affiliation":[{"name":"Psychiatrie Baselland, BL, Schweiz","place":["Liestal"],"department":["Erwachsenenpsychiatrie"]},{"name":"Psychiatrische Universit\u00e4tsklinik Z\u00fcrich, ZH, Schweiz","place":["Z\u00fcrich"],"department":["Klinik f\u00fcr Psychiatrie, Psychotherapie und Psychosomatik"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tri Kurniati","family":"Ambarini","sequence":"additional","affiliation":[{"name":"Universit\u00e4s Airlangga, East Java, Indonesia","place":["Surabaya"],"department":["Department of Psychology"]},{"name":"Universit\u00e4s Airlangga, East Java, Indonesia","place":["Surabaya"],"department":["Center of Mental Health Research and Innovation Development\n                    (MIND)"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1956-9574","authenticated-orcid":false,"given":"Frauke","family":"Schultze-Lutter","sequence":"additional","affiliation":[{"name":"Universit\u00e4s Airlangga, East Java, Indonesia","place":["Surabaya"],"department":["Department of Psychology"]},{"name":"Heinrich-Heine Universit\u00e4t, NRW, Deutschland","place":["D\u00fcsseldorf"],"department":["Klinik f\u00fcr Psychiatrie und Psychotherapie, Medizinische Fakult\u00e4t und\n                    Universit\u00e4tsklinikum D\u00fcsseldorf"]},{"name":"Universit\u00e4re Psychiatrische Dienste Bern,\n                    Universit\u00e4tsklinik f\u00fcr Kinder- und Jugendpsychiatrie und\n                    Psychotherapie, BE, Schweiz","place":["Bern"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.eurpsy.2015.01.010","article-title":"EPA guidance on the early detection of clinical high risk states of\n                    psychoses","volume":"30","author":"F Schultze-Lutter","year":"2015","journal-title":"Eur Psychiatry"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1001\/jamapsychiatry.2015.2324","article-title":"Heterogeneity of Psychosis Risk Within Individuals at Clinical High Risk: A\n                    Meta-analytical 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