{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T23:54:04Z","timestamp":1781654044063,"version":"3.54.5"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zentralbl Chir"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Accurate mediastinal staging of non-small cell lung cancer is essential for guiding curative treatment strategies, particularly regarding the indication for neoadjuvant therapy. This study evaluated pretherapeutic predictive factors for mediastinal lymph node metastases based on routinely collected clinico-pathological data.<\/jats:p>\n                  <jats:p>We retrospectively analysed data from all patients who underwent video-assisted mediastinoscopic lymphadenectomy for mediastinal staging before curatively-intended treatment during a 12-year period. Logistic regression and ROC analyses were used to identify independent risk factors for histologically confirmed N2\/N3 involvement.<\/jats:p>\n                  <jats:p>Clinical N2 status based on PET\/CT was the strongest independent predictor of mediastinal metastasis. However, even patients with cN1 status showed a significantly increased risk. Adenocarcinoma histology (OR 2.3; p\u00a0&lt;\u00a00.01) and central tumour location (OR 2.1; p\u00a0&lt;\u00a00.01) were also independently associated with mediastinal involvement. ROC analysis identified a tumour size \u2265\u00a03\u00a0cm as a potential cutoff, although discrimination was limited (AUC 0.588).<\/jats:p>\n                  <jats:p>Mediastinal lymph node involvement in NSCLC is not restricted to patients with abnormal PET\/CT findings. Central tumours, adenocarcinoma or lesions &gt;\u00a03\u00a0cm should undergo invasive staging, regardless of imaging appearance.<\/jats:p>","DOI":"10.1055\/a-2884-4897","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T23:10:36Z","timestamp":1781651436000},"source":"Crossref","is-referenced-by-count":0,"title":["Predictive Factors for Mediastinal Lymph Node Metastases in Patients with Non-small Cell Lung Cancer, as Detected by Video-assisted Mediastinoscopic Lymphadenectomy"],"prefix":"10.1055","author":[{"given":"Dominik","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Thoraxzentrum Ruhrgebiet, Germany","place":["Herne"],"department":["Klinik f\u00fcr Thoraxchirurgie"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Ewig","sequence":"additional","affiliation":[{"name":"Thoraxzentrum Ruhrgebiet, Germany","place":["Herne"],"department":["Klinik f\u00fcr Pneumologie, Infektiologie und Beatmungsmedizin"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Christian","family":"Christoph","sequence":"additional","affiliation":[{"name":"Thoraxzentrum Ruhrgebiet, Germany","place":["Herne"],"department":["Sektion f\u00fcr Thorakale Onkologie"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tugba","family":"Bas Kaya","sequence":"additional","affiliation":[{"name":"Thoraxzentrum Ruhrgebiet, Germany","place":["Herne"],"department":["Klinik f\u00fcr Thoraxchirurgie"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Greif","sequence":"additional","affiliation":[{"name":"Thoraxzentrum Ruhrgebiet, Germany","place":["Herne"],"department":["Klinik f\u00fcr Thoraxchirurgie"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kolja","family":"Milobinski","sequence":"additional","affiliation":[{"name":"Thoraxzentrum Ruhrgebiet, Germany","place":["Herne"],"department":["Klinik f\u00fcr Thoraxchirurgie"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Oggiano","sequence":"additional","affiliation":[{"name":"Thoraxzentrum Ruhrgebiet, Germany","place":["Herne"],"department":["Klinik f\u00fcr Thoraxchirurgie"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Walles","sequence":"additional","affiliation":[{"name":"Otto-von-Guericke-Universit\u00e4t Magdeburg, Medizinische Fakult\u00e4t, Saxony-Anhalt, Germany","place":["Magdeburg"],"department":["Klinik f\u00fcr Herz- und Thoraxchirurgie, Abteilung Thoraxchirurgie"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4194-8215","authenticated-orcid":false,"given":"Stefan","family":"Welter","sequence":"additional","affiliation":[{"name":"Lungenklinik Hemer, Germany","place":["Hemer"],"department":["Thoraxchirurgie"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erich","family":"Hecker","sequence":"additional","affiliation":[{"name":"Thoraxzentrum Ruhrgebiet, Germany","place":["Herne"],"department":["Klinik f\u00fcr Thoraxchirurgie"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1056\/NEJMoa1102873","article-title":"Reduced lung-cancer mortality with low-dose computed tomographic screening","volume":"365","author":"National Lung Screening Trial Research Team","year":"2011","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1016\/j.jtcvs.2019.09.030","article-title":"Multidisciplinary selection of pulmonary nodules for surgical resection: Diagnosis results and long-term outcomes","volume":"159","author":"ML 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