{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T23:57:38Z","timestamp":1781135858785,"version":"3.54.1"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes for Health Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["NIH NIDDK grant K23DK136967"],"award-info":[{"award-number":["NIH NIDDK grant K23DK136967"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neonatal encephalopathy (NE) is a condition with significant morbidity and mortality, and these neonates are at high risk for glucose disturbances. Growing evidence links hyperglycemia to brain injury independent of NE, yet long-term outcomes data to inform clinical management remain scarce. This study aimed to describe current definitions, detection methods, and management strategies for hyperglycemia in neonates with NE undergoing therapeutic hypothermia (TH).<\/jats:p>\n                  <jats:p>We conducted a cross-sectional survey of 49 Level IV neonatal intensive care units (NICUs) participating in the Children's Hospitals Neonatal Consortium (CHNC) to evaluate center-specific practices for managing hyperglycemia in patients with NE undergoing TH. Individual respondent data were analyzed as the unit of observation using descriptive statistics.<\/jats:p>\n                  <jats:p>Forty-two of 49 centers responded (86% center response rate), yielding 53 individual completed surveys, with 10 centers contributing multiple responses (range 1\u20133 per center). The median threshold for hyperglycemia was 180\u2009mg\/dL (interquartile range, IQR: 160\u2013200). Glucose monitoring frequency ranged from 1 to 6\u2009hours during TH. Point-of-care glucose monitoring was used by 51 respondents (96%); 2 respondents (4%) reported using continuous glucose monitoring in non-research clinical care. Most respondents (48\/53, 91%) reported reducing glucose delivery as the initial intervention for hyperglycemia, followed by insulin initiation if hyperglycemia persisted. The lowest median (range) glucose infusion rate used was 4 (3\u20135) mg\/kg\/min. Most respondents expressed concern about the adverse effects of untreated hyperglycemia (68%), though a substantial proportion (53%) also believed treatment itself could pose risks.<\/jats:p>\n                  <jats:p>Substantial practice variability exists despite shared expertise in defining, monitoring, and managing hyperglycemia in neonates with NE undergoing TH. Although most centers use similar thresholds and stepwise approaches, monitoring strategies vary widely. The coexistence of concern about untreated hyperglycemia (68%) and apprehension about treatment risks (53%) reflects clinical equipoise. These findings underscore the urgent need for prospective studies and evidence-based guidelines to inform best practices in this vulnerable population.<\/jats:p>","DOI":"10.1055\/a-2884-8846","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T23:10:21Z","timestamp":1780096221000},"source":"Crossref","is-referenced-by-count":0,"title":["Current Practices in Hyperglycemia Management in Neonatal Encephalopathy: A Treatment of Hyperglycemia in Neonatal Encephalopathy (THiNE) Consortium Study"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4444-2145","authenticated-orcid":false,"given":"Susan S.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin, Wisconsin, United States","place":["Milwaukee"],"department":["Department of Pediatrics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Montaldo","sequence":"additional","affiliation":[{"name":"University of Campania \u201cLuigi Vanvitelli\u201d, Italy","place":["Naples"],"department":["Department of Woman, Child, and General and Specialized Surgery"]},{"name":"Imperial College London, United Kingdom of Great Britain and Northern Ireland","place":["London"],"department":["Department of Pediatrics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Chavez-Valdez","sequence":"additional","affiliation":[{"name":"Johns Hopkins University, Maryland, United States","place":["Baltimore"],"department":["Department of Pediatrics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria L.V.","family":"Dizon","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine, Illinois, United States","place":["CHICAGO"],"department":["Department of Pediatrics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janessa B.","family":"Law","sequence":"additional","affiliation":[{"name":"University of Washington School of Medicine, Seattle Children's Hospital, Washington, United States","place":["Seattle"],"department":["Department of Pediatrics, Division of Neonatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan M.","family":"McAdams","sequence":"additional","affiliation":[{"name":"University of Wisconsin Madison, Wisconsin, United States","department":["Department of Pediatrics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Mietzsch","sequence":"additional","affiliation":[{"name":"University of Washington School of Medicine, Seattle Children's Hospital, Washington, United States","place":["Seattle"],"department":["Department of Pediatrics, Division of Neonatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Peeples","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center, Nebraska, United States","place":["Omaha"],"department":["Department of Pediatrics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Rao","sequence":"additional","affiliation":[{"name":"Washington University in Saint Louis School of Medicine, Missouri, United States","place":["Saint Louis"],"department":["Department of Pediatrics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Rosenfeld","sequence":"additional","affiliation":[{"name":"The Children's Hospital of Philadelphia, Pennsylvania, United States","place":["Philadelphia"],"department":["Division of Endocrinology and Diabetes"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Rozance","sequence":"additional","affiliation":[{"name":"University of Colorado School of Medicine, Colorado, United States","place":["Aurora"],"department":["Department of Pediatrics and The Children's Hospital, Section of Neonatology, Division of Perinatal Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3072-6569","authenticated-orcid":false,"given":"Elizabeth K.","family":"Sewell","sequence":"additional","affiliation":[{"name":"Emory University, Georgia, United States","place":["Atlanta"],"department":["Department of Pediatrics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily W. Y.","family":"Tam","sequence":"additional","affiliation":[{"name":"Hospital for Sick Children, University of Toronto, Canada","place":["Toronto"],"department":["Department of Paediatrics, Division of Neurology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1038\/s41390-023-02775-z","article-title":"Neonatal encephalopathy and hypoxic-ischemic encephalopathy: moving from controversy to consensus definitions and subclassification","volume":"94","author":"E J Molloy","year":"2023","journal-title":"Pediatr Res"},{"issue":"06","key":"ref2","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1038\/s41390-024-03411-0","article-title":"Neonatal dysglycemia: A review of dysglycemia in relation to brain health and neurodevelopmental outcomes","volume":"96","author":"M Lagac\u00e9","year":"2024","journal-title":"Pediatr 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Pang","year":"2024","journal-title":"J Pineal Res"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2884-8846.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T23:14:33Z","timestamp":1781133273000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2884-8846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,29]]},"references-count":37,"URL":"https:\/\/doi.org\/10.1055\/a-2884-8846","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,5,29]]},"published":{"date-parts":[[2026,5,29]]}}}