{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T23:00:15Z","timestamp":1781046015617,"version":"3.54.1"},"reference-count":153,"publisher":"Georg Thieme Verlag KG","funder":[{"DOI":"10.13039\/501100004489","name":"Mitacs","doi-asserted-by":"crossref","award":["Award# IT31361"],"award-info":[{"award-number":["Award# IT31361"]}],"id":[{"id":"10.13039\/501100004489","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Bleeding disorders arising from dysfunctional platelet\u2013protein interactions pose a significant clinical challenge due to their heterogeneity and complexity. Primary hemostasis is mediated by von Willebrand factor (VWF) and platelet surface receptors GPIb\u03b1 and \u03b1IIb\u03b23. This protein triad is central to clot formation, and interfering with their associated activity can cause several primary hemostasis-related disorders. While traditional therapies, including factor replacement and monoclonal antibodies, have improved outcomes, they are often limited by availability, cost, immunogenicity, and inadequate precision. Recent advances in computational biology and peptide engineering now offer potential for improved hematologic therapeutics. This review outlines two major strategies in peptide drug design: Structure-based modeling and small motif-based design. These approaches enable the creation of short, stable peptides capable of targeting disease-specific protein\u2013protein interactions (PPIs) with high specificity. We highlight the recent development of G14\u2014an artificial intelligence (AI)-designed peptide that selectively disrupts the aberrant GPIb\u03b1\u2013VWF interaction in platelet-type von Willebrand disease. The peptide demonstrated selective inhibition of the enhanced patient-derived platelet aggregation and VWF binding. By combining systems biology, structural modeling, and AI, peptide design can now yield rapid, scalable, and personalized therapies for bleeding disorders. Thus, the growing adoption and integration of intelligently designed peptides offer a new perspective on precision medicine for thrombosis and hemostasis.<\/jats:p>","DOI":"10.1055\/a-2885-4368","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T22:44:53Z","timestamp":1780353893000},"source":"Crossref","is-referenced-by-count":0,"title":["Designing the Future of Hemostasis"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2962-6819","authenticated-orcid":false,"given":"Thomas D. D.","family":"Kazmirchuk","sequence":"additional","affiliation":[{"name":"Queen's University, Canada","place":["Kingston"],"department":["Department of Biomedical and Molecular Sciences"]},{"name":"Carleton University, Canada","place":["Ottawa"],"department":["Department of Biology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiashu","family":"Wang","sequence":"additional","affiliation":[{"name":"Carleton University, Canada","place":["Ottawa"],"department":["Department of Biology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice","family":"Corbette","sequence":"additional","affiliation":[{"name":"Carleton University, Canada","place":["Ottawa"],"department":["Department of Biology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zein Al Abideen","family":"Hammad","sequence":"additional","affiliation":[{"name":"Queen's University, Canada","place":["Kingston"],"department":["Department of Biomedical and Molecular Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha","family":"Othman","sequence":"additional","affiliation":[{"name":"Queen's University, Canada","place":["Kingston"],"department":["Department of Biomedical and Molecular Sciences"]},{"name":"School of Baccalaureate Nursing, St Lawrence College, Canada","place":["Kingston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashkan","family":"Golshani","sequence":"additional","affiliation":[{"name":"Carleton University, Canada","place":["Ottawa"],"department":["Department of Biology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.thromres.2011.11.036","article-title":"Platelets and primary haemostasis","volume":"129","author":"K J Clemetson","year":"2012","journal-title":"Thromb 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