{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T23:25:25Z","timestamp":1787354725998,"version":"build-2736575974"},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropediatrics"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Guillain\u2013Barr\u00e9 syndrome (GBS) is one of the leading causes of acute paralysis in children. Our aim was to describe the clinical characteristics, paraclinical features, and recovery outcomes of children with GBS.<\/jats:p>\n                  <jats:p>This is a prospective study of 40 children diagnosed with GBS from January 2021 to December 2022. Data on demographics, clinical features, treatments, complications, and outcomes were collected at follow-up time points based on the Guillain\u2013Barr\u00e9 disability score (GDS).<\/jats:p>\n                  <jats:p>In the study of 40 children, the number of male children with GBS was predominant (82.5%), and more than 50% of GBS patients were older than 10 years. Seventy-five percent of patients with GBS had a preceding infection, with respiratory tract infections being the most common. The most common initial symptom was leg pain. Bulbar palsy was observed in 47.5% of patients and was a relatively frequent clinical feature in our cohort. Albuminocytological dissociation (ACD) rate within the first 7 days was 73.3%. Based on nerve conduction study results, the phenotypes were distributed as follows: acute inflammatory demyelinating polyneuropathy (AIDP) accounted for 55%; acute motor\u2013sensory axonal neuropathy (AMSAN) for 17.5%; acute motor axonal neuropathy (AMAN) for 10%; inexcitable nerves for 5%; and unclassifiable cases for 12.5%. At the 6-month follow-up, 100% of pediatric patients achieved independent ambulation. Furthermore, a correlation was found between mechanical ventilation and GDS at 1 and 2 months; however, no association was observed at 3 and 6 months' postonset.<\/jats:p>\n                  <jats:p>In pediatric GBS, the most common initial manifestations are limb pain and paresthesia. Most patients achieve good recovery; the need for mechanical ventilation is associated with bulbar weakness, facial paralysis, pneumonia, and severe initial limb weakness.<\/jats:p>","DOI":"10.1055\/a-2886-4749","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T22:57:20Z","timestamp":1781045840000},"page":"273-279","source":"Crossref","is-referenced-by-count":0,"title":["Characteristics and Outcomes of Guillain\u2014Barr\u00e9 Syndrome in Children"],"prefix":"10.1055","volume":"57","author":[{"given":"Tuan Minh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Children's Hospital 1, Vietnam","place":["Ho Chi Minh"],"department":["Department of Infectious Diseases and Neurology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Truc Thanh","family":"Tran","sequence":"additional","affiliation":[{"name":"Children's Hospital 1, Vietnam","place":["Ho Chi Minh"],"department":["Department of Infectious Diseases and Neurology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khanh Hien","family":"Ly","sequence":"additional","affiliation":[{"name":"Children's Hospital 1, Vietnam","place":["Ho Chi Minh"],"department":["Department of Infectious Diseases and Neurology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7990-5298","authenticated-orcid":false,"given":"Mai Thi Hoang","family":"Trang","sequence":"additional","affiliation":[{"name":"Children's Hospital 1, Vietnam","place":["Ho Chi Minh"],"department":["Department of Infectious Diseases and Neurology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1002\/ana.410270707","article-title":"Assessment of current diagnostic criteria for Guillain-Barr\u00e9 syndrome","volume":"27","author":"A K Asbury","year":"1990","journal-title":"Ann Neurol"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.14253\/acn.2020.22.1.13","article-title":"Electrognostic findings of Guillain-Barr\u00e9 syndrome","volume":"22","author":"B A Yoon","year":"2020","journal-title":"Ann Clin Neurophysiol"},{"issue":"08","key":"ref3","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.clinph.2012.01.025","article-title":"Electrodiagnostic criteria for Guillain-Barr\u00e8 syndrome: a critical revision and the need for an update","volume":"123","author":"A Uncini","year":"2012","journal-title":"Clin Neurophysiol"},{"issue":"45","key":"ref4","doi-asserted-by":"crossref","first-page":"79991","DOI":"10.18632\/oncotarget.20620","article-title":"Long-term prognosis of Guillain-Barr\u00e9 syndrome not determined by treatment options?","volume":"8","author":"Y Wang","year":"2017","journal-title":"Oncotarget"},{"issue":"02","key":"ref5","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1159\/000184748","article-title":"The epidemiology of Guillain-Barr\u00e9 syndrome worldwide. 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