{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T23:06:46Z","timestamp":1790118406795,"version":"4.0.1"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Facial Plast Surg"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hair loss is a highly prevalent condition, and patients are increasingly seeking prejuvenation and restoration. This review evaluates contemporary non-surgical hair restoration modalities.<\/jats:p>\n                  <jats:p>Therapeutic strategies have evolved from topical vasodilators to targeted hormonal, regenerative, and device-based interventions reflecting advances in our understanding of follicular biology and technology.<\/jats:p>\n                  <jats:p>Hair follicle cycling is regulated by dermal papilla signaling, epithelial stem cells, and perifollicular vascular and inflammatory environments.<\/jats:p>\n                  <jats:p>Non-surgical therapies include oral and topical pharmacologics, hormonal therapies, platelet-rich plasma (PRP), microneedling, peptide-based treatments, exososomes, nutraceuticals, low-level laser (light) therapy (LLLT), lasers, and transdermal delivery systems.<\/jats:p>\n                  <jats:p>Appropriate candidates include patients with androgenetic alopecia and other non-scarring alopecias; accurate diagnosis is critical.<\/jats:p>\n                  <jats:p>Combination therapy is increasingly utilized to target multiple biologic pathways.<\/jats:p>\n                  <jats:p>Minimal downtime is expected; long-term adherence is required.<\/jats:p>\n                  <jats:p>Emerging therapies include exosome-based treatments, peptides, and advanced drug delivery platforms.<\/jats:p>\n                  <jats:p>Non-surgical modalities are central to prejuvenation and can delay or complement surgical intervention when appropriately applied.<\/jats:p>","DOI":"10.1055\/a-2887-9735","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T23:17:33Z","timestamp":1781306253000},"page":"584-590","source":"Crossref","is-referenced-by-count":0,"title":["Non-Surgical Hair Restoration Options: Current Techniques and Emerging Technologies in Prejuvenation"],"prefix":"10.1055","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6011-4905","authenticated-orcid":false,"given":"Benjamin C.","family":"Paul","sequence":"additional","affiliation":[{"name":"Lenox Hill Hospital, New York, United States","place":["New York"],"department":["Department of Otolaryngology - Head and Neck Surgery, Division of Facial Plastic Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1080\/14656566.2020.1721463","article-title":"A review of the treatment of male pattern hair loss","volume":"21","author":"K York","year":"2020","journal-title":"Expert Opin Pharmacother"},{"key":"ref2","volume-title":"Androgenetic Alopecia","author":"C H Ho","year":"2026"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1067\/mjd.2001.117426","article-title":"Female pattern hair loss","volume":"45","author":"E A Olsen","year":"2001","journal-title":"J Am Acad 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