{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T23:47:01Z","timestamp":1782344821991,"version":"3.54.5"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"CP","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Japan Gastroenterological Endoscopy Society Hokkai","award":["Research grant"],"award-info":[{"award-number":["Research grant"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background\/Study aim The Japan Gastrointestinal Endoscopy Society guidelines indicate that antiplatelet agents (APAs) other than aspirin and P2Y12 receptor antagonists (other APAs) may be interrupted the day before high-bleeding-risk procedures. However, this recommendation is based on low-quality evidence, and no comparative data exist. We aimed to evaluate whether 1-day interruption of other APAs reduced delayed post-polypectomy bleeding (DPPB) in patients undergoing hot snare polypectomy (HSP) or endoscopic mucosal resection (EMR).<\/jats:p>\n                  <jats:p>Patient and methods This retrospective multicenter cohort study included consecutive patients who received monotherapy with other APAs and underwent colorectal HSP\/EMR between April 2020 and March 2024. The patients were categorized into the interruption and continuation groups. We compared the patient backgrounds, polyp findings, use of prophylactic clipping, intraprocedural bleeding, and DPPB between the two groups. Propensity score matching (PSM) was performed to reduce confounding factors.<\/jats:p>\n                  <jats:p>Results In total, 506 patients received monotherapy with other APAs, and 192 matched pairs were evaluated. The baseline and procedural characteristics were well balanced after PSM. DPPB occurred in 2 patients (1.0%) in both the interruption and continuation groups (p = 1; absolute risk difference, 0.0% [95% confidence interval: \u22122.0 to 2.0]). Thromboembolic events occurred in 1 and 0 patients in the interruption and continuation groups, respectively.<\/jats:p>\n                  <jats:p>Conclusions One-day interruption of other APAs was not associated with a clear reduction in DPPB risk during HSP\/EMR. Given the risk of thromboembolism after interruption, routine discontinuation may be unnecessary. Prospective studies are needed to reassess the current guideline recommendations.<\/jats:p>","DOI":"10.1055\/a-2888-5234","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T23:16:42Z","timestamp":1781219802000},"source":"Crossref","is-referenced-by-count":0,"special_numbering":"S","title":["Temporary Interruption versus Continuation of Non-aspirin, Non-P2Y12 Antiplatelet Monotherapy for Delayed Post-polypectomy Bleeding"],"prefix":"10.1055","volume":"14","author":[{"given":"Yutaka","family":"Okagawa","sequence":"additional","affiliation":[{"name":"Sapporo Medical University School of Medicine, Hokkaido Prefecture, Japan","place":["Sapporo"],"department":["Division of Medical Oncology, Department of Internal Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Sato","sequence":"additional","affiliation":[{"name":"Sapporo Medical University School of Medicine, Hokkaido Prefecture, Japan","place":["Sapporo"],"department":["Division of Medical Oncology, Department of Internal Medicine"]},{"name":"Sapporo Kyoritsu Gorinbashi Hospital, Hokkaido Prefecture, Japan","place":["Sapporo"],"department":["Department of Gastroenterology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Hirakawa","sequence":"additional","affiliation":[{"name":"Sapporo Medical University School of Medicine, Hokkaido Prefecture, Japan","place":["Sapporo"],"department":["Division of Medical Oncology, Department of Internal Medicine"]},{"name":"Hokkaido Cancer Center, Hokkaido Prefecture, Japan","place":["Sapporo"],"department":["Department of Gastroenterology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Seto","sequence":"additional","affiliation":[{"name":"Tonan Hospital, Hokkaido Prefecture, Japan","place":["Sapporo"],"department":["Department of Gastroenterology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Ito","sequence":"additional","affiliation":[{"name":"Otaru Ekisaikai Hospital, Hokkaido Prefecture, Japan","place":["Otaru"],"department":["Department of Gastroenterology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginji","family":"Oomori","sequence":"additional","affiliation":[{"name":"Oji General Hospital, Hokkaido Prefecture, Japan","place":["Tomakomai"],"department":["Department of Gastroenterology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saki","family":"Saeki","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Date Hospital, Hokkaido Prefecture, Japan","place":["Date"],"department":["Department of Gastroenterology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4415-0214","authenticated-orcid":false,"given":"Shutaro","family":"Oiwa","sequence":"additional","affiliation":[{"name":"Hokkaido Cancer Center, Hokkaido Prefecture, Japan","place":["Sapporo"],"department":["Department of Gastroenterology"]},{"name":"Steel Memorial Muroran Hospital, Hokkaido Prefecture, Japan","place":["Muroran"],"department":["Department of Gastroenterology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naotaka","family":"Hayasaka","sequence":"additional","affiliation":[{"name":"Sapporo Kiyota Hospital, Hokkaido Prefecture, Japan","place":["Sapporo"],"department":["Department of Gastroenterology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Miura","sequence":"additional","affiliation":[{"name":"Rumoi City Hospital, Hokkaido Prefecture, Japan","place":["Rumoi"],"department":["Department of Gastroenterology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Abe","sequence":"additional","affiliation":[{"name":"Steel Memorial Muroran Hospital, Hokkaido Prefecture, Japan","place":["Muroran"],"department":["Department of Gastroenterology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Minami","sequence":"additional","affiliation":[{"name":"Oji General Hospital, Hokkaido Prefecture, Japan","place":["Tomakomai"],"department":["Department of Gastroenterology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Sumiyoshi","sequence":"additional","affiliation":[{"name":"Tonan Hospital, Hokkaido Prefecture, Japan","place":["Sapporo"],"department":["Department of Gastroenterology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Nagaoka","sequence":"additional","affiliation":[{"name":"Higashi Sapporo Hospital, Hokkaido Prefecture, Japan","place":["Sapporo"],"department":["Department of Gastroenterology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Hisai","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Date Hospital, Hokkaido Prefecture, Japan","place":["Date"],"department":["Department of Gastroenterology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Katsuki","sequence":"additional","affiliation":[{"name":"Otaru Ekisaikai Hospital, Hokkaido Prefecture, Japan","place":["Otaru"],"department":["Department of Gastroenterology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Ohnishi","sequence":"additional","affiliation":[{"name":"Sapporo Medical University School of Medicine, Japan","place":["Sapporo"],"department":["Division of Public Health, Department of Social Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1393-9442","authenticated-orcid":false,"given":"Kohichi","family":"Takada","sequence":"additional","affiliation":[{"name":"Sapporo Medical University School of Medicine, Hokkaido Prefecture, Japan","place":["Sapporo"],"department":["Division of Medical Oncology, Department of Internal Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1056\/NEJM199312303292701","article-title":"Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup","volume":"329","author":"S J Winawer","year":"1993","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1056\/NEJMoa1100370","article-title":"Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths","volume":"366","author":"A G Zauber","year":"2012","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/den.12183","article-title":"Guidelines for gastroenterological endoscopy in patients undergoing antithrombotic treatment","volume":"26","author":"K Fujimoto","year":"2014","journal-title":"Dig Endosc"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.gie.2015.09.035","article-title":"The management of antithrombotic agents for patients undergoing GI endoscopy","volume":"83","author":"ASGE Standards of Practice Committee","year":"2016","journal-title":"Gastrointest Endosc"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1136\/gutjnl-2021-325184","article-title":"Endoscopy in patients on antiplatelet or anticoagulant therapy: British Society of Gastroenterology (BSG) and European Society of Gastrointestinal Endoscopy (ESGE) guideline update","volume":"70","author":"A M Veitch","year":"2021","journal-title":"Gut"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S1474-4422(10)70198-8","article-title":"Cilostazol for prevention of secondary stroke (CSPS 2): an aspirin-controlled, double-blind, randomised non-inferiority trial","volume":"9","author":"Y Shinohara","year":"2010","journal-title":"Lancet Neurol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00464-020-07402-0","article-title":"Effect of antiplatelet agent number, types, and pre-endoscopic management on post-polypectomy bleeding: validation of endoscopy guidelines","volume":"35","author":"K Watanabe","year":"2021","journal-title":"Surg Endosc"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.jstrokecerebrovasdis.2009.07.010","article-title":"Stroke prevention by cilostazol in patients with atherothrombosis: meta-analysis of placebo-controlled randomized trials","volume":"18","author":"S Uchiyama","year":"2009","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"ref9","first-page":"3051.e4","article-title":"Risk of postcolonoscopy thromboembolic events: a real-world cohort study","volume":"21","author":"Y K Li","year":"2023","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1159\/000531061","article-title":"Safety of cold snare polypectomy during continuous use of antithrombotic drugs for delayed post-polypectomy bleeding: a pilot study","volume":"41","author":"J Hayasaka","year":"2023","journal-title":"Dig Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.1007\/s00464-018-6048-9","article-title":"Prospective analysis of delayed colorectal post-polypectomy bleeding","volume":"32","author":"S K Park","year":"2018","journal-title":"Surg Endosc"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1186\/s12876-020-01454-1","article-title":"The effect of prophylactic hemoclip placement and risk factors of delayed post-polypectomy bleeding in polyps sized 6 to 20 millimeters: a propensity score matching analysis","volume":"20","author":"C W Chen","year":"2020","journal-title":"BMC Gastroenterol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software \u2018EZR\u2019 for medical statistics","volume":"48","author":"Y Kanda","year":"2013","journal-title":"Bone Marrow Transplant"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"E587","DOI":"10.1055\/s-0043-105578","article-title":"Cold snare polypectomy reduced delayed postpolypectomy bleeding compared with conventional hot polypectomy: a propensity score-matching analysis","volume":"5","author":"T Yamashina","year":"2017","journal-title":"Endosc Int Open"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1055\/s-0030-1256346","article-title":"Factors that predict bleeding following endoscopic mucosal resection of large colonic lesions","volume":"43","author":"A J Metz","year":"2011","journal-title":"Endoscopy"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1111\/apt.12292","article-title":"Meta-analysis: colonoscopic post-polypectomy bleeding in patients on continued clopidogrel therapy","volume":"37","author":"S Gandhi","year":"2013","journal-title":"Aliment Pharmacol Ther"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1443-1661.2010.00998.x","article-title":"Antiplatelet agents and bleeding time after endoscopic biopsy of the gastric antrum in Japanese patients","volume":"22","author":"T Yamamoto","year":"2010","journal-title":"Dig Endosc"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1365-2036.2006.02759.x","article-title":"Spanish-Italian collaborative Group for the Epidemiology of gastrointestinal bleeding. Upper gastrointestinal bleeding associated with antiplatelet drugs","volume":"23","author":"L Ib\u00e1\u00f1ez","year":"2006","journal-title":"Aliment Pharmacol Ther"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1007\/s00384-022-04253-0","article-title":"Prevention of delayed post-polypectomy bleeding by prophylactic clipping after endoscopic colorectal polypectomy: a meta-analysis","volume":"37","author":"Z Yu","year":"2022","journal-title":"Int J Color Dis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1097\/MCG.0000000000002042","article-title":"The use of clips to prevent post-polypectomy bleeding: a clinical review","volume":"58","author":"M A O\u2019Mara","year":"2024","journal-title":"J Clin Gastroenterol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"362.e23","DOI":"10.1016\/j.cgh.2021.05.012","article-title":"The role of clips in preventing delayed bleeding after colorectal polyp resection: an individual patient data meta-analysis","volume":"20","author":"A S Turan","year":"2022","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"868.e3","DOI":"10.1016\/j.gie.2019.10.013","article-title":"Clinical validation of risk scoring systems to predict risk of delayed bleeding after EMR of large colorectal lesions","volume":"91","author":"E Alb\u00e9niz","year":"2020","journal-title":"Gastrointest Endosc"}],"container-title":["Endoscopy International Open"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2888-5234.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T22:58:33Z","timestamp":1782341913000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2888-5234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,11]]},"references-count":22,"journal-issue":{"issue":"CP","published-online":{"date-parts":[[2026,1,13]]},"published-print":{"date-parts":[[2026]]}},"alternative-id":["a28885234"],"URL":"https:\/\/doi.org\/10.1055\/a-2888-5234","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2364-3722","2196-9736"],"issn-type":[{"value":"2364-3722","type":"print"},{"value":"2196-9736","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,6,11]]},"published":{"date-parts":[[2026,6,11]]}}}