{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T23:50:47Z","timestamp":1781826647843,"version":"3.54.5"},"reference-count":39,"publisher":"Georg Thieme Verlag KG","funder":[{"name":"Meiji Yasuda Mental Health Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study aimed to examine whether neonatal auditory brainstem conduction, as indexed by the interpeak latency between waves I and V (I\u2013V IPL) on the auditory brainstem response (ABR), is associated with long-term language outcomes in preterm children.<\/jats:p>\n                  <jats:p>This retrospective cohort study included 45 preterm infants born at \u226433 weeks of gestation without hearing loss who underwent ABR testing at term-equivalent age. Demographic and clinical variables, ABR wave latencies and interpeak latencies, and language\u2013social (L\u2013S) developmental quotients (DQs) at 3 and 5\u20136 years of age were collected. L\u2013S DQs were assessed using the Kyoto Scale of Psychological Development 2001.<\/jats:p>\n                  <jats:p>Spearman's correlation analysis showed that longer I\u2013V IPL at term-equivalent age was significantly correlated with lower L\u2013S DQ scores at both 3 years of age (rs\n                  \u2009=\u2009\u2212\u20090.32, p\u2009=\u20090.03) and 5\u20136 years of age (rs\n                  \u2009=\u2009\u2212\u20090.39, p\u2009=\u20090.04). After adjustment for sex and age, a linear mixed-effects model showed that longer I\u2013V IPL remained significantly associated with lower L\u2013S DQ scores at 5\u20136 years (\u03b2\u2009=\u2009\u2212\u200921.00, 95% CI: \u221240.6 to \u22121.40).<\/jats:p>\n                  <jats:p>The findings suggest that longer neonatal I\u2013V IPL at term-equivalent age may be associated with poorer long-term language outcomes in preterm children. Neonatal measurement of I\u2013V IPL may provide additional information for clinicians assessing the need for long-term follow-up of language development.<\/jats:p>","DOI":"10.1055\/a-2889-6371","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:48:13Z","timestamp":1780706893000},"source":"Crossref","is-referenced-by-count":0,"title":["Associations between Neonatal Auditory Brainstem Response and Long-Term Language Development in Preterm Children"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8830-3887","authenticated-orcid":false,"given":"Akari","family":"Takai","sequence":"additional","affiliation":[{"name":"Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan","place":["Kyoto"],"department":["Department of Pediatrics"]},{"name":"Hananoki Medical Welfare Center, Japan","place":["Kameoka"],"department":["Department of 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Pediatrics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Zuiki","sequence":"additional","affiliation":[{"name":"Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan","place":["Kyoto"],"department":["Department of Pediatrics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takenori","family":"Tozawa","sequence":"additional","affiliation":[{"name":"Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan","place":["Kyoto"],"department":["Department of Pediatrics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan","place":["Kyoto"],"department":["Department of Otolaryngology - Head and Neck Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Teramukai","sequence":"additional","affiliation":[{"name":"Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan","place":["Kyoto"],"department":["Department of Biostatistics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Iehara","sequence":"additional","affiliation":[{"name":"Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan","place":["Kyoto"],"department":["Department of Pediatrics"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.jpeds.2010.10.032","article-title":"Language abilities in children who were very preterm and\/or very low birth weight: A meta-analysis","volume":"158","author":"N Barre","year":"2011","journal-title":"J Pediatr"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1542\/peds.2011-1728","article-title":"Language functions in preterm-born children: A systematic review and meta-analysis","volume":"129","author":"I L van Noort-van der Spek","year":"2012","journal-title":"Pediatrics"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00401-017-1718-6","article-title":"White matter injury in the preterm infant: Pathology and mechanisms","volume":"134","author":"S A Back","year":"2017","journal-title":"Acta Neuropathol"},{"issue":"07","key":"ref4","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1056\/NEJMoa053792","article-title":"Neonatal MRI to predict neurodevelopmental outcomes in preterm infants","volume":"355","author":"L J Woodward","year":"2006","journal-title":"N Engl J 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Neurophysiol"},{"issue":"05","key":"ref11","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1203\/01.PDR.0000084084.62571.12","article-title":"Time course of brainstem pathophysiology during first month in term infants after perinatal asphyxia, revealed by MLS BAER latencies and intervals","volume":"54","author":"Z D Jiang","year":"2003","journal-title":"Pediatr Res"},{"issue":"01","key":"ref12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.pediatrneurol.2007.03.006","article-title":"Changes in brainstem auditory evoked response latencies in term neonates with hyperbilirubinemia","volume":"37","author":"Z D Jiang","year":"2007","journal-title":"Pediatr Neurol"},{"issue":"06","key":"ref13","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1203\/PDR.0b013e31819ed5ae","article-title":"Relative maturation of peripheral and central regions of the human brainstem from preterm to term and the influence of preterm birth","volume":"65","author":"Z D 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Res"},{"issue":"02","key":"ref23","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.joto.2024.05.003","article-title":"A longitudinal study on auditory developmental responses in very preterm, moderately preterm and late preterm infants","volume":"19","author":"J Seethapathy","year":"2024","journal-title":"J Otol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"106164","DOI":"10.1016\/j.earlhumdev.2024.106164","article-title":"Maturational delay in the brainstem auditory pathway of very preterm babies with apnoea","volume":"200","author":"J K Jiang","year":"2025","journal-title":"Early Hum Dev"},{"issue":"01","key":"ref25","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1203\/00006450-199201000-00013","article-title":"Neonatal auditory brainstem response failure of very low birth weight infants: 8-year outcome","volume":"31","author":"C Cox","year":"1992","journal-title":"Pediatr Res"},{"issue":"05","key":"ref26","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0022-3476(95)70183-4","article-title":"Prediction of outcome at school entry in neonatal intensive care unit survivors, with use of clinical and electrophysiologic techniques","volume":"127","author":"A Majnemer","year":"1995","journal-title":"J Pediatr"},{"issue":"10","key":"ref27","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.earlhumdev.2014.07.014","article-title":"Auditory neural myelination is associated with early childhood language development in premature infants","volume":"90","author":"S B Amin","year":"2014","journal-title":"Early Hum Dev"},{"issue":"07","key":"ref28","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1111\/apa.15136","article-title":"Neonatal brainstem auditory function associates with early receptive language development in preterm children","volume":"109","author":"J Antinmaa","year":"2020","journal-title":"Acta Paediatr"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3389\/fped.2020.00485","article-title":"Prediction of delayed neurodevelopment in infants using brainstem auditory evoked potentials and the Bayley II scales","volume":"8","author":"X Wang","year":"2020","journal-title":"Front Pediatr"},{"issue":"07","key":"ref30","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1136\/archdischild-2018-315843","article-title":"Language in 2-year-old children born preterm and term: a cohort study","volume":"104","author":"K Sanchez","year":"2019","journal-title":"Arch Dis Child"},{"issue":"741","key":"ref31","doi-asserted-by":"crossref","first-page":"n741","DOI":"10.1136\/bmj.n741","article-title":"Neurodevelopmental outcomes at age 5 among children born preterm: EPIPAGE-2 cohort study","volume":"373","author":"V Pierrat","year":"2021","journal-title":"BMJ"},{"key":"ref32","first-page":"233121651668116","article-title":"Evidence for a right-ear advantage in newborn hearing screening results","volume":"20","author":"D Ari-Even Roth","year":"2016","journal-title":"Trends Hear"},{"issue":"01","key":"ref33","first-page":"17","article-title":"Comparison of Kyoto Scale of Psychological Development and Bayley Scales of Infant Development Second Edition among Japanese infants","volume":"2","author":"N Tatsuta","year":"2013","journal-title":"J Spec Educ Res"},{"issue":"04","key":"ref34","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.braindev.2015.10.010","article-title":"Developmental assessment of VLBW infants at 18 months of age: A comparison study between KSPD and Bayley III","volume":"38","author":"Y Kono","year":"2016","journal-title":"Brain Dev"},{"issue":"10","key":"ref35","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1111\/ped.12969","article-title":"Developmental quotient to estimate intelligence in autism spectrum disorder","volume":"58","author":"K Kawabe","year":"2016","journal-title":"Pediatr Int"},{"issue":"05","key":"ref36","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/jnr.24914","article-title":"Gender differences in early stages of language development. 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