{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:42:46Z","timestamp":1792190566372,"version":"4.4.0"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"10","funder":[{"name":"Medizinische Fakult\u00e4t, Universit\u00e4t Augsburg","award":["intramurale Forschungsf\u00f6rderung"],"award-info":[{"award-number":["intramurale Forschungsf\u00f6rderung"]}],"id":[{"id":"https:\/\/ror.org\/03p14d497","id-type":"ROR","asserted-by":"crossref"}]},{"name":"DZPG","award":["FKZ: 01EE2303C"],"award-info":[{"award-number":["FKZ: 01EE2303C"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fortschr Neurol Psychiatr"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To investigate potential associations of exposure to adverse childhood\nexperiences (ACE) with pain sensitivity and to investigate a potential\ninteracting role of ACE exposure and sex on pain sensitivity<\/jats:p>\n                  <jats:p>We investigated a sample of young and healthy adults (n=55; 43.6% male; mean\nage: 22.0 years). ACE were assessed using the Childhood Trauma Questionnaire\n(CTQ). Pain sensitivity was assessed by measuring heat-pain threshold (HPT)\nat the left lower leg. ANCOVA models were calculated to assess the\nassociation of ACE exposure and HPT as well as the interaction of ACE\nexposure and sex.<\/jats:p>\n                  <jats:p>A total of 23 participants (41.8%) were classified as \u2018exposed to any ACE\u2019\naccording to CTQ results. There was no significant association of ACE\nexposure and HPT. Furthermore, there was no significant interaction of ACE\nexposure and sex.<\/jats:p>\n                  <jats:p>Further studies investigating samples of more severely traumatized\nparticipants and a more precise characterization of ACE exposure are needed\nto better investigate a potential relation of ACE and pain sensitivity.<\/jats:p>","DOI":"10.1055\/a-2890-0892","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T22:38:46Z","timestamp":1783636726000},"page":"443-448","source":"Crossref","is-referenced-by-count":1,"title":["Evaluating the relationship of exposure to adverse childhood\nexperiences and pain in healthy subjects"],"prefix":"10.1055","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4440-8422","authenticated-orcid":false,"given":"Bernhard C. L.","family":"Maier","sequence":"additional","affiliation":[{"name":"University of Augsburg, Germany","place":["Augsburg"],"department":["Department of Psychiatry, Psychotherapy and Psychosomatics, Medical\nFaculty"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie-Kathrin","family":"Greiner","sequence":"additional","affiliation":[{"name":"University of Augsburg, Germany","place":["Augsburg"],"department":["Department of Psychiatry, Psychotherapy and Psychosomatics, Medical\nFaculty"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Justus","family":"G\u00f6ller","sequence":"additional","affiliation":[{"name":"University of Augsburg, Germany","place":["Augsburg"],"department":["Department of Medical Psychology and Sociology, Medical\nFaculty"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Kunz","sequence":"additional","affiliation":[{"name":"University of Augsburg, Germany","place":["Augsburg"],"department":["Department of Medical Psychology and Sociology, Medical\nFaculty"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alkomiet","family":"Hasan","sequence":"additional","affiliation":[{"name":"University of Augsburg, Germany","place":["Augsburg"],"department":["Department of Psychiatry, Psychotherapy and Psychosomatics, Medical\nFaculty"]},{"name":"DZPG (German Center for Mental Health), Germany","place":["Partner Site Munich\/Augsburg"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"104127","DOI":"10.1016\/j.chiabu.2019.104127","article-title":"Adverse childhood experiences and associated health outcomes: A systematic\nreview and meta-analysis","volume":"97","author":"K Petruccelli","year":"2019","journal-title":"Child Abuse Negl"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1017\/S0033291716000301","article-title":"A meta-analysis on pain sensitivity in self-injury","volume":"46","author":"J Koenig","year":"2016","journal-title":"Psychol Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1007\/s11920-018-0872-4","article-title":"Psychiatry and Pain Management: at the Intersection of Chronic Pain and Mental\nHealth","volume":"20","author":"J Goesling","year":"2018","journal-title":"Curr Psychiatry Rep"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.1097\/j.pain.0000000000001939","article-title":"The revised International Association for the Study of Pain definition of pain:\nconcepts, challenges, and compromises","volume":"161","author":"S N Raja","year":"2020","journal-title":"Pain"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.parkreldis.2017.12.031","article-title":"Pain sensitivity in Parkinson\u2019s disease: Systematic review and\nmeta-analysis","volume":"48","author":"S Sung","year":"2018","journal-title":"Parkinsonism Relat Disord"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1097\/j.pain.0000000000001231","article-title":"Quantitative sensory testing in patients with migraine: a systematic review and\nmeta-analysis","volume":"159","author":"H Nahman-Averbuch","year":"2018","journal-title":"Pain"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1136\/bmjdrc-2020-001566","article-title":"Altered pain processing in patients with type 1 and 2 diabetes: systematic\nreview and meta-analysis of pain detection thresholds and pain modulation\nmechanisms","author":"E Sierra-Silvestre","year":"2020","journal-title":"BMJ Open Diabetes Res Care"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.1097\/j.pain.0000000000000586","article-title":"Altered pressure pain thresholds and increased wind-up in adult patients with\nchronic back pain with a history of childhood maltreatment: a quantitative\nsensory testing study","volume":"157","author":"J Tesarz","year":"2016","journal-title":"Pain"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1097\/01.j.pain.0000460350.30707.8d","article-title":"Distinct quantitative sensory testing profiles in nonspecific chronic back pain\nsubjects with and without psychological trauma","volume":"156","author":"J Tesarz","year":"2015","journal-title":"Pain"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.2147\/NDT.S87703","article-title":"Childhood adversities and laboratory pain perception","volume":"11","author":"K Pieritz","year":"2015","journal-title":"Neuropsychiatr Dis Treat"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"104750","DOI":"10.1016\/j.jpain.2024.104750","article-title":"The association between childhood maltreatment and pain sensitivity in a\nhigh-risk adolescent population","volume":"27","author":"M Zarchev","year":"2025","journal-title":"J Pain"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.jpain.2008.12.001","article-title":"Sex, gender, and pain: a review of recent clinical and experimental\nfindings","volume":"10","author":"R B Fillingim","year":"2009","journal-title":"J Pain"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1038\/nrn3360","article-title":"Sex differences in pain and pain inhibition: multiple explanations of a\ncontroversial phenomenon","volume":"13","author":"J S Mogil","year":"2012","journal-title":"Nat Rev Neurosci"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/j.pain.2014.01.031","article-title":"Sex differences in experimental pain among healthy children: a systematic review\nand meta-analysis","volume":"155","author":"K E Boerner","year":"2014","journal-title":"Pain"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/s0304-3959(97)00199-1","article-title":"Sex differences in the perception of noxious experimental stimuli: a\nmeta-analysis","volume":"74","author":"J L Riley","year":"1998","journal-title":"Pain"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.pain.2011.11.025","article-title":"A systematic literature review of 10 years of research on sex\/gender and\nexperimental pain perception - part 1: are there really differences between\nwomen and men?","volume":"153","author":"M Racine","year":"2012","journal-title":"Pain"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1007\/s10865-023-00440-8","article-title":"Adversity type and timing predict temporal summation of pain in African-American\nadults","volume":"46","author":"M C Morris","year":"2023","journal-title":"J Behav Med"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1002\/ejp.2169","article-title":"Vicarious facilitation of facial responses to pain","volume":"28","author":"P J G\u00f6ller","year":"2024","journal-title":"Eur J Pain Lond Engl"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/s0145-2134(02)00541-0","article-title":"Development and validation of a brief screening version of the Childhood Trauma\nQuestionnaire","volume":"27","author":"D P Bernstein","year":"2003","journal-title":"Child Abuse Negl"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1348\/014466505X29657","article-title":"The short-form version of the Depression Anxiety Stress Scales (DASS-21):\nconstruct validity and normative data in a large non-clinical sample","volume":"44","author":"J D Henry","year":"2005","journal-title":"Br J Clin Psychol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.23668\/psycharchives.4579","volume-title":"DASS. Depressions-Angst-Stress-Skalen - deutschsprachige Kurzfassung\n[Verfahrensdokumentation und Fragebogen mit Auswertung]","author":"P Nilges","year":"2021"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1097\/j.pain.0000000000002870","article-title":"The association between adverse childhood experiences and peripartal pain\nexperience","volume":"164","author":"K F Zehetmeier","year":"2023","journal-title":"Pain"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"e13047","DOI":"10.1111\/adb.13047","article-title":"A randomised, double-blind study investigating the relationship between early\nchildhood trauma and the rewarding effects of morphine","volume":"26","author":"M Carlyle","year":"2021","journal-title":"Addict Biol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1097\/01.ajp.0000149801.46864.39","article-title":"Is self-reported childhood abuse history associated with pain perception among\nhealthy young women and men?","volume":"21","author":"R B Fillingim","year":"2005","journal-title":"Clin J Pain"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1097\/j.pain.0000000000001704","article-title":"The association of early life stressors with pain sensitivity and pain\nexperience at 22 years","volume":"161","author":"R Waller","year":"2020","journal-title":"Pain"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1016\/j.jpain.2013.05.003","article-title":"Maternal deprivation is associated with sex-dependent alterations in nociceptive\nbehavior and neuroinflammatory mediators in the rat following peripheral nerve\ninjury","volume":"14","author":"N N Burke","year":"2013","journal-title":"J Pain"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1097\/AJP.0b013e3182132963","article-title":"Characteristics of response to experimental pain in sexually abused women","volume":"27","author":"M Granot","year":"2011","journal-title":"Clin J Pain"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1186\/s13148-019-0731-0","article-title":"Childhood traumatization is associated with differences in TRPA1 promoter\nmethylation in female patients with multisomatoform disorder with pain as the\nleading bodily symptom","volume":"11","author":"J Achenbach","year":"2019","journal-title":"Clin Epigenetics"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.neubiorev.2017.01.039","article-title":"Age changes in pain perception: A systematic-review and meta-analysis of age\neffects on pain and tolerance thresholds","volume":"75","author":"S Lautenbacher","year":"2017","journal-title":"Neurosci Biobehav Rev"}],"container-title":["Fortschritte der Neurologie \u00b7 Psychiatrie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2890-0892.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:39:30Z","timestamp":1792190370000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2890-0892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,9]]},"references-count":29,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,10,16]]},"published-print":{"date-parts":[[2026,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2890-0892","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0720-4299","1439-3522"],"issn-type":[{"value":"0720-4299","type":"print"},{"value":"1439-3522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,9]]}}}