{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T23:47:48Z","timestamp":1782172068743,"version":"3.54.5"},"reference-count":100,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fortschr Neurol Psychiatr"],"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Die Gattung Naegleria ist eine taxonomische Unterfamilie, die 47\n                    freilebende Am\u00f6ben umfasst. Die Gattung ist weltweit in warmen Wasser- oder\n                    Bodenhabitaten zu finden. Die Art Naegleria fowleri ist wahrscheinlich\n                    die bekannteste Spezies dieser Gattung. Als fakultativer Parasit ist der Protist\n                    nicht auf einen Wirt angewiesen, um seinen Lebenszyklus zu vollenden. Er kann\n                    jedoch Menschen infizieren, indem er bei Wasserkontakt, z. B. beim Schwimmen, in\n                    die Nase gelangt und entlang des Geruchsnervs zum Gehirn wandert. Dort\n                    verursacht er eine eitrige Meningitis (prim\u00e4re Am\u00f6benmeningoenzephalitis oder\n                    PAME). Die Symptome sind schwerwiegend, und der Tod tritt in der Regel innerhalb\n                    der ersten Woche ein. PAME ist eine be\u00e4ngstigende Infektionskrankheit, f\u00fcr die\n                    es weder ein nachgewiesenes Heilmittel noch einen Impfstoff gibt. Um die\n                    Krankheit einzud\u00e4mmen und den Patienten eine \u00dcberlebenschance zu geben, muss\n                    schnell gehandelt werden. Eine schnelle Diagnose ist daher von entscheidender\n                    Bedeutung. PAME wird durch den Nachweis von Am\u00f6ben im Liquor und sp\u00e4ter im\n                    Liquor cerebrospinalis diagnostiziert. Zu diesem Zweck werden Liquorproben\n                    kultiviert und gef\u00e4rbt und schlie\u00dflich mikroskopisch untersucht. Molekulare\n                    Techniken wie PCR oder ELISA unterst\u00fctzen die mikroskopische Analyse und sichern\n                    die Diagnose.<\/jats:p>","DOI":"10.1055\/a-2890-0961","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T23:05:43Z","timestamp":1782169543000},"source":"Crossref","is-referenced-by-count":0,"title":["Die Pathologie der Hirnfresseram\u00f6be Naegleria\n                    fowleri"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9368-6985","authenticated-orcid":false,"given":"Yannick","family":"Borkens","sequence":"additional","affiliation":[{"name":"Charite Medical Faculty Berlin, Germany","place":["Berlin"],"department":["Institut f\u00fcr Pathologie"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1016\/S0140-6736(96)07495-8","article-title":"Global mortality, disability, and the contribution of risk factors: Global\n                    Burden of Disease Study","volume":"349","author":"C J Murray","year":"1997","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1111\/j.1574-6976.2012.00336.x","article-title":"Persistent intracellular pathogens","volume":"36","author":"C Dehio","year":"2012","journal-title":"FEMS Microbiol Rev"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s00108-013-3332-6","article-title":"Reisemedizin","volume":"55","author":"T 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