{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T22:49:23Z","timestamp":1782341363257,"version":"3.54.5"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fortschr Neurol Psychiatr"],"abstract":"Zusammenfassung<\/jats:title>\n Die digitale Transformation ver\u00e4ndert Diagnostik, Monitoring und Therapie der\n Multiplen Sklerose grundlegend. Durch die Integration multimodaler Daten aus\n Bildgebung, Labor, klinischen Assessments, patientenberichteten Ergebnissen\n sowie kontinuierlichen Messungen via Wearables entstehen hochaufl\u00f6sende,\n longitudinale Profile des Krankheitsverlaufs. Auf dieser Datengrundlage\n erm\u00f6glichen moderne Analyseverfahren und K\u00fcnstliche Intelligenz pr\u00e4diktive\n Modelle zur Krankheitsaktivit\u00e4t, Progression und Therapieantwort und\n unterst\u00fctzen personalisierte Entscheidungswege. Digitale Patientenpfade und\n Patientenportale er\u00f6ffnen neue Optionen f\u00fcr partizipative, standardisierte\n Versorgung, w\u00e4hrend Telemedizin, Telerehabilitation und digitale\n Gesundheitsanwendungen die Betreuung orts- und zeitunabh\u00e4ngig erg\u00e4nzen. In der\n Forschung beschleunigen Real-World-Daten, f\u00f6deriertes Lernen und virtuelle,\n dezentralisierte Studien patientenzentrierte Evidenzgenerierung. Konzepte wie\n der digitale Zwilling skizzieren die n\u00e4chste Entwicklungsstufe einer\n simulationsgest\u00fctzten Pr\u00e4zisionsmedizin. Zentrale Herausforderungen betreffen\n Datenschutz und Datensicherheit, Datenqualit\u00e4t, Interoperabilit\u00e4t sowie Bias,\n Transparenz und Nachvollziehbarkeit algorithmischer Entscheidungen. Insgesamt\n bietet die Digitalisierung substanzielle Chancen, Krankheitsaktivit\u00e4t fr\u00fcher zu\n erkennen, Therapieziele zu optimieren und die Lebens- und Versorgungsqualit\u00e4t zu\n verbessen \u2013 vorausgesetzt, dass technische, regulatorische und ethische\n Voraussetzungen konsequent adressiert und in skalierbare Versorgungsmodelle\n \u00fcberf\u00fchrt werden.<\/jats:p>","DOI":"10.1055\/a-2890-0999","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T22:31:31Z","timestamp":1782340291000},"source":"Crossref","is-referenced-by-count":0,"title":["Digitale Transformation bei Multipler Sklerose \u2013 Fortschritte in\n Diagnostik, Monitoring und patientenzentrierter Versorgung"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0097-8589","authenticated-orcid":false,"given":"Isabel","family":"Voigt","sequence":"additional","affiliation":[{"name":"Technische Universit\u00e4t Dresden, SN, Germany","place":["Dresden"],"department":["Zentrum f\u00fcr klinische Neurowissenschaften, Klinik und Poliklinik f\u00fcr\n Neurologie, Medizinische Fakult\u00e4t und Universit\u00e4tsklinikum Carl Gustav\n Carus"]},{"name":"Technische Universit\u00e4t\n Dresden, SN, Germany","place":["Dresden"],"department":["Centre for Tactile Internet with Human-in-the-Loop,\n Exzellenzcluster"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hernan","family":"Inojosa","sequence":"additional","affiliation":[{"name":"Technische Universit\u00e4t Dresden, SN, Germany","place":["Dresden"],"department":["Zentrum f\u00fcr klinische Neurowissenschaften, Klinik und Poliklinik f\u00fcr\n Neurologie, Medizinische Fakult\u00e4t und Universit\u00e4tsklinikum Carl Gustav\n Carus"]},{"name":"Technische Universit\u00e4t\n Dresden, SN, Germany","place":["Dresden"],"department":["Centre for Tactile Internet with Human-in-the-Loop,\n Exzellenzcluster"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Pawlitzki","sequence":"additional","affiliation":[{"name":"Heinrich-Heine-Universit\u00e4t\n D\u00fcsseldorf, NRW, Germany","place":["D\u00fcsseldorf"],"department":["Klinik f\u00fcr Neurologie, Medizinische Fakult\u00e4t und Universit\u00e4tsklinikum\n D\u00fcsseldorf"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Masanneck","sequence":"additional","affiliation":[{"name":"Heinrich-Heine-Universit\u00e4t\n D\u00fcsseldorf, NRW, Germany","place":["D\u00fcsseldorf"],"department":["Klinik f\u00fcr Neurologie, Medizinische Fakult\u00e4t und Universit\u00e4tsklinikum\n D\u00fcsseldorf"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven G\u00fcnther","family":"Meuth","sequence":"additional","affiliation":[{"name":"Heinrich-Heine-Universit\u00e4t\n D\u00fcsseldorf, NRW, Germany","place":["D\u00fcsseldorf"],"department":["Klinik f\u00fcr 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